TWIST2 binds CDH1 gene promoter

Stable Identifier
R-HSA-9765169
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TWIST2 binds CDH1 gene promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Binding of TWIST2 to the CDH1 gene promoter was demonstrated in pancreatic (Yang et al. 2016) and breast (Wang et al. 2021) cancer cell lines. In pancreatic cancer cell lines, HIF2A promotes binding of TWIST2 to the CDH1 gene promoter (Yang et al. 2016).
Literature References
PubMed ID Title Journal Year
26842802 HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer

Yang, J, Zhang, X, Zhang, Y, Zhu, D, Zhang, L, Li, Y, Zhu, Y, Li, D, Zhou, J

J Exp Clin Cancer Res 2016
33608512 Distinct Ring1b complexes defined by DEAD-box helicases and EMT transcription factors synergistically enhance E-cadherin silencing in breast cancer

Wang, Y, Sun, Y, Shang, C, Chen, L, Chen, H, Wang, D, Zeng, X

Cell Death Dis 2021
Participants
Input
Output
Participates
as an event of
Authored
Orlic-Milacic, M  (2022-02-14)
Created
Orlic-Milacic, M  (2022-02-14)
Cite Us!