TWIST2 represses CDH1 gene transcription

Stable Identifier
R-HSA-9765175
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
3/5
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TWIST2 represses CDH1 gene transcription
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TWIST2 directly represses transcription from the CDH1 gene promoter (Yang et al. 2016, Wang et al. 2021). TWIST2-mediated repression of the CDH1 gene transcription is associated with the recruitment of RNF2 (RING1B) complexes and repressive methylation of the CDH1 gene promoter (Wang et al. 2021) and is implicated in epithelial-to-mesenchymal transition (EMT) (Yang et al. 2016).
Literature References
PubMed ID Title Journal Year
26842802 HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer

Yang, J, Zhang, X, Zhang, Y, Zhu, D, Zhang, L, Li, Y, Zhu, Y, Li, D, Zhou, J

J Exp Clin Cancer Res 2016
33608512 Distinct Ring1b complexes defined by DEAD-box helicases and EMT transcription factors synergistically enhance E-cadherin silencing in breast cancer

Wang, Y, Sun, Y, Shang, C, Chen, L, Chen, H, Wang, D, Zeng, X

Cell Death Dis 2021
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
TWIST2:CDH1 gene [nucleoplasm] (Homo sapiens)
Active Unit
TWIST2 [nucleoplasm]
Authored
Orlic-Milacic, M  (2022-02-14)
Created
Orlic-Milacic, M  (2022-02-14)
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