SNAI2 binds CDH1 gene promoter

Stable Identifier
R-HSA-9768533
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SNAI2 binds CDH1 gene promoter
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The transcription factor SNAI2 (SLUG) binds to the E-box elements in the promoter of the CDH1 (E-cadherin) gene. This is supported by chromatin immunoprecipitation in human synovial sarcoma cell lines (Saito et al, 2006), by an electromobility shift assay (EMSA) in Madin-Darby canine kidney cells (Hayashida et al, 2006) and by a reporter assay using human CDH1 gene promoter and human SNAI2 (Hajra et al. 2002). SNAI2 efficient repression and binding to human and mouse E-cadherin promoter require an intact zinc finger motif ZF3 or ZF4 (Villarejo et al. 2014).
Literature References
PubMed ID Title Journal Year
16943193 Calreticulin represses E-cadherin gene expression in Madin-Darby canine kidney cells via Slug

Hayashida, Y, Urata, Y, Muroi, E, Kono, T, Miyata, Y, Nomata, K, Kanetake, H, Kondo, T, Ihara, Y

J Biol Chem 2006
16849535 SYT-SSX1 and SYT-SSX2 interfere with repression of E-cadherin by snail and slug: a potential mechanism for aberrant mesenchymal to epithelial transition in human synovial sarcoma

Saito, T, Nagai, M, Ladanyi, M

Cancer Res 2006
11912130 The SLUG zinc-finger protein represses E-cadherin in breast cancer

Hajra, KM, Chen, DY, Fearon, ER

Cancer Res 2002
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Authored
Rothfels, K  (2024-03-01)
Reviewed
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Orlic-Milacic, M  (2022-03-11)
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