TCF3 represses CDH1 gene transcription

Stable Identifier
R-HSA-9765756
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
3/5
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TCF3 represses CDH1 gene transcription
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TCF3 (also known as E47) directly represses CDH1 gene transcription in both mouse (Perez-Moreno et al. 2001; Bolós et al. 2003) and human (Zhu et al. 2016; Xu et al. 2021).
Literature References
PubMed ID Title Journal Year
34462424 Loss of ID3 drives papillary thyroid cancer metastasis by targeting E47-mediated epithelial to mesenchymal transition

Xu, S, Mo, C, Lin, J, Yan, Y, Liu, X, Wu, K, Zhang, H, Zhu, Y, Chen, L, Chen, X

Cell Death Discov 2021
26212009 PAK5-mediated E47 phosphorylation promotes epithelial-mesenchymal transition and metastasis of colon cancer

Zhu, G, Li, X, Guo, B, Ke, Q, Dong, M, Li, F

Oncogene 2016
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
TCF3:CDH1 gene [nucleoplasm] (Homo sapiens)
Active Unit
TCF3 [nucleoplasm]
Authored
Orlic-Milacic, M  (2022-02-16)
Created
Orlic-Milacic, M  (2022-02-16)
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