ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter

Stable Identifier
R-HSA-9930711
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter
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ZEB1 recruits a corepressor protein TLE1 (Transducin-like enhancer of split 1) to the CDH1 gene promoter (Yao et al. 2016, Yao et al. 2017), leading to its deacetylation (Yao et al. 2017). TLE1 was previously shown to recruit histone deacetylase HDAC1 to the human CDH1 gene promoter (Yao et al. 2014), and ZEB1 was also shown to recruit HDAC1 and HDAC2 to the CDH1 gene promoter (Aghdassi et al. 2012).
Literature References
PubMed ID Title Journal Year
25446087 TLE1 promotes EMT in A549 lung cancer cells through suppression of E-cadherin

Yao, X, Ireland, SK, Pham, T, Temple, B, Chen, R, Raj, MH, Biliran, H

Biochem Biophys Res Commun 2014
29069783 TLE1 inhibits anoikis and promotes tumorigenicity in human lung cancer cells through ZEB1-mediated E-cadherin repression

Yao, X, Pham, T, Temple, B, Gray, S, Cannon, C, Hardy, C, Fletcher, K, Ireland, SK, Hossain, A, Chen, R, Abdel-Mageed, AB, Biliran, H

Oncotarget 2017
27655370 The Anoikis Effector Bit1 Inhibits EMT through Attenuation of TLE1-Mediated Repression of E-Cadherin in Lung Cancer Cells

Yao, X, Pham, T, Temple, B, Gray, S, Cannon, C, Chen, R, Abdel-Mageed, AB, Biliran, H

PLoS One 2016
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Orthologous Events
ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter (Bos taurus)
ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter (Caenorhabditis elegans)
ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter (Canis familiaris)
ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter (Drosophila melanogaster)
ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter (Gallus gallus)
ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter (Mus musculus)
ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter (Rattus norvegicus)
ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter (Sus scrofa)
ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2024-12-05)
Created
Orlic-Milacic, M  (2024-12-05)
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