MCRIP1 binds CTBP1

Stable Identifier
R-HSA-9765974
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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MCRIP1 binds CTBP1
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MCRIP1 forms a complex with CTBP1. Binding of MCRIP1 to CTBP1 prevents formation of the complex between ZEB1 and CTBP1. Phosphorylation of MCRIP1 by activated MAPKs (ERKs) prevents association of MCRIP1 with CTBP1 (Ichikawa et al. 2015). MCRIP1 is also able to form a complex with CTBP2, but the biological significance of this complex is unknown (Ichikawa et al. 2015). Mouse Mcrip1 and Ctbp1/Ctbp2 were also shown to interact, with Mcrip1 competitively inhibiting binding of other transcription factors to Ctbp1 (Weng et al. 2019).
Literature References
PubMed ID Title Journal Year
25728771 MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP

Ichikawa, K, Kubota, Y, Nakamura, T, Weng, JS, Tomida, T, Saito, H, Takekawa, M

Mol Cell 2015
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Input
Output
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as an event of
This event is regulated
Negatively by
Regulator
p-T,Y MAPK monomers and dimers [nucleoplasm] (Homo sapiens)
Authored
Orlic-Milacic, M  (2022-02-17)
Created
Orlic-Milacic, M  (2022-02-17)
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