Reactome | GP6 [plasma membrane]

GP6 [plasma membrane]

Stable Identifier

R-HSA-114574

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Platelet Glycoprotein VI

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Locations in the PathwayBrowser

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Hemostasis (Homo sapiens)

- Cell surface interactions at the vascular wall (Homo sapiens)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
      - GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
      - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
- Platelet Adhesion to exposed collagen (Homo sapiens)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
      - GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
      - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
  - GPVI binds Fyn and Lyn (Homo sapiens)
    - GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
      - GP6 [plasma membrane] (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
      - GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
  - Interaction of GPVI and FceRI gamma (Homo sapiens)
    - GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
      - GP6 [plasma membrane] (Homo sapiens)
    - GP6 [plasma membrane] (Homo sapiens)
- Platelet activation, signaling and aggregation (Homo sapiens)
  - GPVI-mediated activation cascade (Homo sapiens)
    - Binding of Syk tyrosine kinase (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Homo sapiens)
      - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - GPVI stimulates PI3K beta, gamma (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - SYK autophosphorylates (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - p-Y348-SYK dissociates (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HCN6 GP6

Gene Names

GP6

Chain

signal peptide:1-20, chain:21-339

Reference Genes

BioGPS Gene:51206 GP6

COSMIC (genes):GP6 GP6

CTD Gene:51206 GP6

dbSNP Gene:51206 GP6

ENSEMBL:ENSG00000088053 GP6

HGNC:14388 GP6

KEGG:hsa:51206 GP6

Monarch:51206 GP6

NCBI Gene:51206 GP6

OMIM:605546 GP6

UCSC:Q9HCN6 GP6

Reference Transcript

Participates

as an input of

Interaction of GPVI and FceRI gamma (Homo sapiens)

as a component of

Inferred To

GP6 [plasma membrane] (Bos taurus)

GP6 [plasma membrane] (Canis familiaris)

GP6 [plasma membrane] (Sus scrofa)

GP6 [plasma membrane] (Xenopus tropicalis)

Gp6 [plasma membrane] (Mus musculus)

Gp6 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001077368.2, NP_001242946.2, NP_057447.5

OpenTargets

ENSG00000088053

ENSEMBL

ENSP00000478674, ENST00000616456, ENST00000310373, ENSP00000478918, ENST00000612096, ENSG00000088053, ENST00000333884, ENSP00000481524, ENSG00000274050, ENSP00000480178, ENSG00000278670, ENSP00000481125, ENST00000617954, ENSP00000478709, ENSP00000479034, ENST00000612184, ENST00000622589, ENSP00000484029, ENSP00000483314, ENSP00000482601, ENST00000612862, ENSG00000275931, ENSG00000275633, ENSP00000334552, ENSP00000479513, ENSP00000479975, ENSP00000394922, ENSP00000478025, ENST00000610596, ENST00000616319, ENST00000613649, ENST00000615407, ENST00000622653, ENSG00000276211, ENST00000622279, ENSG00000278316, ENSP00000481583, ENSP00000479668, ENST00000611436, ENST00000621278, ENST00000610746, ENST00000614662, ENST00000619136, ENST00000614889, ENSP00000480243, ENSG00000274566, ENSG00000277439, ENST00000417454, ENSG00000276065, ENSP00000483612, ENSP00000481075, ENST00000613801, ENSP00000308782, ENSP00000479873

GeneCards

GP6

HPA

ENSG00000088053-GP6

PRO

Q9HCN6

Pharos - Targets

Q9HCN6

GlyGen

Q9HCN6

Orphanet

GP6

HMDB Protein

HMDBP13518

PDB

5OU9, 7R58, 2GI7, 7NMU, 5OU7, 5OU8

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07948 LYN	7	LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y397-LYN [plasma membrane] (R-HSA-2454229) p-Y397-LYN [cytosol] (R-HSA-8942608) LYN [plasma membrane] (R-HSA-197943) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903)	0.641	5
UniProt:P06241 FYN	6	FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745)	0.564	2
UniProt:P62158 CALM			0.524	2