Reactome | GP6 [plasma membrane]

GP6 [plasma membrane]

Stable Identifier

R-HSA-114574

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Platelet Glycoprotein VI

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Locations in the PathwayBrowser

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Hemostasis (Homo sapiens)

- Cell surface interactions at the vascular wall (Homo sapiens)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
      - GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
      - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
- Platelet Adhesion to exposed collagen (Homo sapiens)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
      - GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
      - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
  - GPVI binds Fyn and Lyn (Homo sapiens)
    - GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
      - GP6 [plasma membrane] (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
      - GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
  - Interaction of GPVI and FceRI gamma (Homo sapiens)
    - GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
      - GP6 [plasma membrane] (Homo sapiens)
    - GP6 [plasma membrane] (Homo sapiens)
- Platelet activation, signaling and aggregation (Homo sapiens)
  - GPVI-mediated activation cascade (Homo sapiens)
    - Binding of Syk tyrosine kinase (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Homo sapiens)
      - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - GPVI stimulates PI3K beta, gamma (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - SYK autophosphorylates (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - p-Y348-SYK dissociates (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HCN6 GP6

Gene Names

GP6

Chain

signal peptide:1-20, chain:21-339

Reference Genes

BioGPS Gene:51206 GP6

COSMIC (genes):GP6 GP6

CTD Gene:51206 GP6

dbSNP Gene:51206 GP6

ENSEMBL:ENSG00000088053 GP6

ENSEMBL:ENSG00000274050 GP6

ENSEMBL:ENSG00000274566 GP6

ENSEMBL:ENSG00000275633 GP6

ENSEMBL:ENSG00000275931 GP6

ENSEMBL:ENSG00000276065 GP6

ENSEMBL:ENSG00000276211 GP6

ENSEMBL:ENSG00000277439 GP6

ENSEMBL:ENSG00000278316 GP6

ENSEMBL:ENSG00000278670 GP6

HGNC:14388 GP6

KEGG Gene (Homo sapiens):51206 GP6

Monarch:51206 GP6

NCBI Gene:51206 GP6

OMIM:605546 GP6

UCSC:Q9HCN6 GP6

Reference Transcript

Other Identifiers

11734187_a_at

11734188_x_at

16875549

220336_s_at

2GI7

3870991

3870992

3870993

3870994

3870995

3870996

3870998

3870999

3871000

3871001

3871002

3871004

3871005

51206

5OU7

5OU8

5OU9

66482

8039294

A_23_P27784

A_33_P3461416

AAI04833

AAI11964

AB035073

AB043819

AB043820

AB043821

AC011476

BAA89353

BAB12245

BAB12246

BAB12247

BC104832

BC111963

CCDS42626

CCDS46184

CCDS58678

ENSG00000088053

ENSG00000277439

ENSP00000308782

ENSP00000334552

ENSP00000394922

ENSP00000479873

ENSP00000483314

ENSP00000484029

ENST00000310373

ENST00000310373.7

ENST00000333884

ENST00000333884.2

ENST00000417454

ENST00000417454.5

ENST00000612184

ENST00000616456

ENST00000622279

EntrezGene:51206

EntrezGene:GP6

g9955913_3p_a_at

GO:0002376

GO:0003674

GO:0004888

GO:0005515

GO:0005518

GO:0005575

GO:0005576

GO:0005615

GO:0005623

GO:0005886

GO:0005887

GO:0006950

GO:0007165

GO:0007167

GO:0007596

GO:0007599

GO:0008150

GO:0009986

GO:0016020

GO:0016021

GO:0030168

GO:0038023

GO:0040011

GO:0043226

GO:0048870

GO:0050900

GO:0070062

GO:0097197

GP6

GP6-201

GP6-202

GP6-203

GP6-218

GP6-219

GP6-222

HGNC:14388

HPA066482

ILMN_1732269

ILMN_2223772

IPR003598

IPR003599

IPR007110

IPR013783

IPR036179

K7EIW7

LRG_560

LRG_560t1

LRG_560t2

LRG_560t3

MIM:605546

MIM:614201

NM_001083899

NM_001256017

NM_016363

NP_001077368

NP_001242946

NP_057447

PF13895

PH_hs_0029558

SM00408

SM00409

TC19002721.hg

UPI000013C631

UPI000013F000

UPI000022A9E0

Participant Of

input

Interaction of GPVI and FceRI gamma

hasComponent

Inferred To

GP6 [plasma membrane] (Bos taurus)

GP6 [plasma membrane] (Canis familiaris)

GP6 [plasma membrane] (Mus musculus)

GP6 [plasma membrane] (Rattus norvegicus)

GP6 [plasma membrane] (Sus scrofa)

GP6 [plasma membrane] (Xenopus tropicalis)

Homologues of GP6 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_057447.5, NP_001077368.2, NP_001242946.2

OpenTargets

ENSG00000088053

GeneCards

Q9HCN6

PRO

Q9HCN6

Orphanet

18999

PDB

5OU8, 5OU7, 2GI7, 5OU9

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07948 LYN	5	p-Y396-LYN [plasma membrane] (R-HSA-2454229) LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y397-LYN [cytosol] (R-HSA-8942608) LYN [plasma membrane] (R-HSA-197943)	0.641	5
UniProt:P06241 FYN	6	MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) p-Y420-FYN [cytosol] (R-HSA-391821) FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410)	0.564	2
UniProt:P62158 CALM			0.524	2