Reactome | GP6 [plasma membrane]

GP6 [plasma membrane]

Stable Identifier

R-HSA-114574

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Platelet Glycoprotein VI

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Locations in the PathwayBrowser

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Hemostasis (Homo sapiens)

- Cell surface interactions at the vascular wall (Homo sapiens)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
      - GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
      - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
- Platelet Adhesion to exposed collagen (Homo sapiens)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
      - GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
      - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
  - GPVI binds Fyn and Lyn (Homo sapiens)
    - GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
      - GP6 [plasma membrane] (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
      - GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
  - Interaction of GPVI and FceRI gamma (Homo sapiens)
    - GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
      - GP6 [plasma membrane] (Homo sapiens)
    - GP6 [plasma membrane] (Homo sapiens)
- Platelet activation, signaling and aggregation (Homo sapiens)
  - GPVI-mediated activation cascade (Homo sapiens)
    - Binding of Syk tyrosine kinase (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Homo sapiens)
      - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - GPVI stimulates PI3K beta, gamma (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - SYK autophosphorylates (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - p-Y348-SYK dissociates (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HCN6 GP6

Gene Names

GP6

Chain

signal peptide:1-20, chain:21-339

Reference Genes

BioGPS Gene:51206 GP6

COSMIC (genes):GP6 GP6

CTD Gene:51206 GP6

dbSNP Gene:51206 GP6

ENSEMBL:ENSG00000088053 GP6

ENSEMBL:ENSG00000274050 GP6

ENSEMBL:ENSG00000274566 GP6

ENSEMBL:ENSG00000275633 GP6

ENSEMBL:ENSG00000275931 GP6

ENSEMBL:ENSG00000276065 GP6

ENSEMBL:ENSG00000276211 GP6

ENSEMBL:ENSG00000277439 GP6

ENSEMBL:ENSG00000278316 GP6

ENSEMBL:ENSG00000278670 GP6

HGNC:14388 GP6

KEGG Gene (Homo sapiens):51206 GP6

Monarch:51206 GP6

NCBI Gene:51206 GP6

OMIM:605546 GP6

UCSC:Q9HCN6 GP6

Reference Transcript

Other Identifiers

11734187_a_at

11734188_x_at

16875549

220336_s_at

3870991

3870992

3870993

3870994

3870995

3870996

3870998

3870999

3871000

3871001

3871002

3871004

3871005

51206

8039294

A_23_P27784

A_33_P3461416

GO:0002376

GO:0003674

GO:0004888

GO:0005515

GO:0005518

GO:0005575

GO:0005576

GO:0005615

GO:0005886

GO:0005887

GO:0006950

GO:0007165

GO:0007167

GO:0007596

GO:0007599

GO:0008150

GO:0009986

GO:0016020

GO:0016021

GO:0030168

GO:0038023

GO:0040011

GO:0043226

GO:0048870

GO:0050900

GO:0070062

GO:0097197

HMNXSV003000526

ILMN_1732269

ILMN_2223772

PH_hs_0029558

TC19002721.hg

g9955913_3p_a_at

Participates

as an input of

Interaction of GPVI and FceRI gamma (Homo sapiens)

as a component of

Inferred To

GP6 [plasma membrane] (Bos taurus)

GP6 [plasma membrane] (Canis familiaris)

GP6 [plasma membrane] (Sus scrofa)

Gp6 [plasma membrane] (Mus musculus)

Gp6 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001077368.2, NP_057447.5, NP_001242946.2

OpenTargets

ENSG00000088053

HPA

ENSG00000088053-GP6

GeneCards

Q9HCN6

Ensembl

ENST00000333884, ENSP00000394922, ENSP00000334552, ENST00000417454, ENSG00000277439, ENST00000622279, ENSP00000479873, ENSP00000308782, ENSG00000088053, ENST00000616456, ENST00000612184, ENSP00000483314, ENSP00000484029, ENST00000310373

PRO

Q9HCN6

Pharos - Targets

Q9HCN6

GlyGen

Q9HCN6

Orphanet

18999

PDB

5OU9, 5OU7, 2GI7, 5OU8

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07948 LYN	7	p-Y397-LYN [cytosol] (R-HSA-8942608) LYN [cytosol] (R-HSA-354251) p-Y396-LYN [plasma membrane] (R-HSA-2454229) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) LYN [plasma membrane] (R-HSA-197943) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728)	0.641	5
UniProt:P06241 FYN	6	FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y420-FYN [cytosol] (R-HSA-391821)	0.564	2
UniProt:P0DP24 CALM			0.524	2

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