Reactome | ADAM12 [plasma membrane]

ADAM12 [plasma membrane]

Stable Identifier

R-HSA-179792

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ADAM 12 metalloprotease, ADAM 12 sheddase

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External Reference Information

External Reference

UniProt:O43184 ADAM12

Gene Names

ADAM12, MLTN, UNQ346/PRO545

Chain

signal peptide:1-28, propeptide:29-207, chain:208-909

Reference Genes

BioGPS Gene:8038 ADAM12

COSMIC (genes):ADAM12 ADAM12

CTD Gene:8038 ADAM12

dbSNP Gene:8038 ADAM12

ENSEMBL:ENSG00000148848 ADAM12

HGNC:190 ADAM12

KEGG:hsa:8038 ADAM12

Monarch:8038 ADAM12

NCBI Gene:8038 ADAM12

OMIM:602714 ADAM12

UCSC:O43184 ADAM12

Reference Transcript

Participates

as a member of

Inferred To

Adam12 [plasma membrane] (Mus musculus)

Adam12 [plasma membrane] (Rattus norvegicus)

adam12b [plasma membrane] (Danio rerio)

mde10 [plasma membrane] (Schizosaccharomyces pombe)

ADAM12 [plasma membrane] (Canis familiaris)

ADAM12 [plasma membrane] (Gallus gallus)

ADAM12 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_067673.2, NP_003465.3, NP_001275903.1, NP_001275904.1

Guide to Pharmacology - Targets

1660

ENSEMBL

ENSP00000357668, ENSP00000357665, ENSG00000148848, ENST00000368679, ENST00000368676

OpenTargets

ENSG00000148848

GeneCards

ADAM12

HPA

ENSG00000148848-ADAM12

ZINC - Substances

ADA12_HUMAN

ZINC target

O43184

PRO

O43184

Pharos - Targets

O43184

GlyGen

O43184

ZINC - Predictions - Purchasable

ADA12_HUMAN

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276)	0.558	2
UniProt:P08631 HCK	2	HCK [cytosol] (R-HSA-167708) p-HCK [cytosol] (R-HSA-9676060)	0.558	2
UniProt:P07948 LYN	7	LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y397-LYN [plasma membrane] (R-HSA-2454229) p-Y397-LYN [cytosol] (R-HSA-8942608) LYN [plasma membrane] (R-HSA-197943) MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728)	0.558	2
UniProt:Q5HYK7 SH3D19	1	SH3D19 [cytosol] (R-HSA-434202)	0.556	4

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