Reactome | p-Y88-CDKN1B [nucleoplasm]

p-Y88-CDKN1B [nucleoplasm]

Stable Identifier

R-HSA-8942808

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-Y88-p27KIP1

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Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)
      - Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (Homo sapiens)
        
        Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
        
        p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P46527 CDKN1B

Gene Names

CDKN1B, KIP1, p27

Chain

chain:1-198

Reference Genes

BioGPS Gene:1027 CDKN1B

COSMIC (genes):CDKN1B CDKN1B

CTD Gene:1027 CDKN1B

dbSNP Gene:1027 CDKN1B

ENSEMBL:ENSG00000111276 CDKN1B

ENSEMBL_homo_sapiens_GENE:ENSG00000111276.12 CDKN1B

HGNC:1785 CDKN1B

KEGG Gene (Homo sapiens):1027 CDKN1B

Monarch:1027 CDKN1B

NCBI Gene:1027 CDKN1B

OMIM:600778 CDKN1B

Reference Transcript

RefSeq:NM_004064.4 CDKN1B

Other Identifiers

1027

11717091_s_at

11748603_a_at

16748477

2034_s_at

209112_PM_at

209112_at

33847_s_at

33848_r_at

3405445

3405446

3405449

3405450

3405451

3405452

3405453

3405454

3405455

3405456

52535_s_at

63732_at

7954029

A_14_P102019

A_14_P108230

A_23_P204696

A_24_P81841

GE521549

GE81344

GE86978

GO:0000079

GO:0000082

GO:0000278

GO:0001666

GO:0001890

GO:0001934

GO:0004860

GO:0004861

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0006260

GO:0006351

GO:0006355

GO:0006813

GO:0006913

GO:0006915

GO:0006977

GO:0007010

GO:0007049

GO:0007096

GO:0007219

GO:0007346

GO:0007507

GO:0007605

GO:0008284

GO:0008285

GO:0009410

GO:0009749

GO:0012501

GO:0014070

GO:0019901

GO:0019903

GO:0019914

GO:0022414

GO:0023052

GO:0030154

GO:0030163

GO:0030308

GO:0030332

GO:0030334

GO:0030544

GO:0031116

GO:0031410

GO:0031464

GO:0031625

GO:0032355

GO:0032991

GO:0033673

GO:0036211

GO:0042326

GO:0043200

GO:0043226

GO:0043231

GO:0043434

GO:0044877

GO:0045732

GO:0045736

GO:0045740

GO:0045892

GO:0045930

GO:0046686

GO:0048102

GO:0048839

GO:0048856

GO:0048870

GO:0050680

GO:0050877

GO:0051087

GO:0051168

GO:0051179

GO:0051726

GO:0060090

GO:0060767

GO:0060770

GO:0065003

GO:0071236

GO:0071285

GO:0071407

GO:0071456

GO:0090398

GO:0098772

GO:0140014

GO:0140678

GO:1902746

GO:1902806

GO:1904019

GO:1904030

GO:1904036

GO:1904706

GO:1905179

GO:1990757

GO:2000045

HMNXSV003015053

HMNXSV003043906

ILMN_1722811

ILMN_2196347

PH_hs_0012886

TC12000178.hg

TC12002253.hg

g12805034_3p_at

Participates

as a component of

Other forms of this molecule

p-S10 CDKN1B [cytosol]

p-S10 CDKN1B [nucleoplasm]

p-T157-CDKN1B [cytosol]

CDKN1B [cytosol]

p-Y88-CDKN1B [cytosol]

p-T187-CDKN1B [nucleoplasm]

CDKN1B [nucleoplasm]

Inferred To

phospho-cdkn1b [nucleoplasm] (Xenopus tropicalis)

phospho-CDKN1B [nucleoplasm] (Bos taurus)

phospho-CDKN1B [nucleoplasm] (Canis familiaris)

phospho-CDKN1B [nucleoplasm] (Sus scrofa)

phospho-Cdkn1b [nucleoplasm] (Mus musculus)

phospho-Cdkn1b [nucleoplasm] (Rattus norvegicus)

phospho-cdkn1bb [nucleoplasm] (Danio rerio)

phospho-dap [nucleoplasm] (Drosophila melanogaster)

Modified Residues

Name

O4'-phospho-L-tyrosine at 88

Coordinate

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_004055.1

OpenTargets

ENSG00000111276

GeneCards

P46527

HPA

ENSG00000111276-CDKN1B

Ensembl

ENST00000228872, ENSP00000507272, ENSP00000228872, ENSG00000111276, ENST00000614874

PRO

P46527

Pharos - Targets

P46527

Orphanet

18426

PDB

5UQ3, 7B5M, 1H27, 6P8F, 7ORT, 1JSU, 2AST, 8BYA, 7B5L, 6P8E, 8BZO, 7B5R, 8BYL, 7ORH, 7OR8, 6P8G, 6ATH, 7ORG, 7ORS

Interactors (42)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24941 CDK2	5	p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) p-CDK2 [nucleoplasm] (R-HSA-68370) CDK2 [cytosol] (R-HSA-157440) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.974	31
UniProt:P20248 CCNA2	3	PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [cytosol] (R-HSA-157444) CCNA2 [nucleoplasm] (R-HSA-68905)	0.967	21
UniProt:Q00535 CDK5	4	CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809)	0.94	14
UniProt:P11802 CDK4	3	CDK4 [cytosol] (R-HSA-68330) CDK4 [nucleoplasm] (R-HSA-113843) p-T172-CDK4 [nucleoplasm] (R-HSA-113830)	0.934	13
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [nucleoplasm] (R-HSA-75811) p-T286-CCND1 [cytosol] (R-HSA-75813)	0.905	12
UniProt:P24864 CCNE1	3	CCNE1 [nucleoplasm] (R-HSA-68363) CCNE1 [cytosol] (R-HSA-157443) Unfolded CCNE1 [cytosol] (R-HSA-6813836)	0.888	12
UniProt:P06493 CDK1	11	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-Y4-CDK1 [cytosol] (R-HSA-9836187) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.886	9
UniProt:P30279 CCND2	2	CCND2 [cytosol] (R-HSA-68340) CCND2 [nucleoplasm] (R-HSA-113827)	0.818	8
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.8	5
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.799	6
UniProt:O96020 CCNE2	3	Unfolded CCNE2 [cytosol] (R-HSA-6813844) CCNE2 [cytosol] (R-HSA-157452) CCNE2 [nucleoplasm] (R-HSA-68367)	0.788	6
UniProt:P78396 CCNA1	3	PolyUb-CCNA1 [nucleoplasm] (R-HSA-6783068) CCNA1 [cytosol] (R-HSA-157446) CCNA1 [nucleoplasm] (R-HSA-68891)	0.783	7
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [nucleoplasm] (R-HSA-975554)	0.75	4
UniProt:P14635 CCNB1	4	CCNB1 [nucleoplasm] (R-HSA-68901) p-4S-CCNB1 [cytosol] (R-HSA-170058) p-4S-CCNB1 [nucleoplasm] (R-HSA-170049) CCNB1 [cytosol] (R-HSA-157451)	0.744	6
UniProt:P30281 CCND3	2	CCND3 [cytosol] (R-HSA-68333) CCND3 [nucleoplasm] (R-HSA-113835)	0.738	9
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.724	5
UniProt:O15131 KPNA5	2	KPNA5 [nucleoplasm] (R-HSA-1176068) KPNA5 [cytosol] (R-HSA-1176062)	0.718	6
UniProt:Q00534 CDK6	3	CDK6 [cytosol] (R-HSA-68336) CDK6 [nucleoplasm] (R-HSA-141283) p-T177-CDK6 [nucleoplasm] (R-HSA-69628)	0.706	7
UniProt:O95067 CCNB2	1	CCNB2 [cytosol] (R-HSA-68897)	0.669	4
UniProt:Q00526 CDK3			0.643	4
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.63	3
UniProt:Q62120 Jak2	11	phospho-p-Y1007,Y1008-JAK2 [cytosol] (R-MMU-9005327) p-Jak2 [cytosol] (R-MMU-8950633) phospho-p-JAK2 [cytosol] (R-MMU-210621) phospho-p-Y813-JAK2 [cytosol] (R-MMU-997248) JAK2 [endosome lumen] (R-MMU-2002372) JAK2 [cytosol] (R-MMU-210620) phospho-p-Y1007-JAK2 [cytosol] (R-MMU-873799) Jak2 [cytosol] (R-MMU-205743) phospho-p-12Y-JAK2 [cytosol] (R-MMU-2586516) p-Y1007-Jak2 [cytosol] (R-MMU-997296) p-12Y-Jak2 [cytosol] (R-MMU-2586515)	0.626	7
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.609	2
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.602	3
UniProt:P16949 STMN1	1	STMN1 [cytosol] (R-HSA-9612290)	0.589	3
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.576	4
UniProt:Q5MJ70 SPDYA			0.556	3
UniProt:Q5JR59-3 MTUS2			0.556	3
UniProt:Q8N9N5-2 BANP			0.556	3
UniProt:Q9NVV9 THAP1			0.556	3
UniProt:P07948 LYN	7	MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) LYN [plasma membrane] (R-HSA-197943) p-Y397-LYN [cytosol] (R-HSA-8942608) p-Y397-LYN [plasma membrane] (R-HSA-2454229) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) LYN [cytosol] (R-HSA-354251)	0.544	2
UniProt:Q15418 RPS6KA1	7	RPS6KA1 [nucleoplasm] (R-HSA-199860) p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [cytosol] (R-HSA-444256) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm] (R-HSA-444292)	0.544	2
UniProt:P61586 RHOA	6	RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082) RHOA [cytosol] (R-HSA-194866) RHOA [cell junction] (R-HSA-2134503) RHOA [plasma membrane] (R-HSA-194510)	0.544	3
UniProt:P50613 CDK7	1	CDK7 [nucleoplasm] (R-HSA-69218)	0.527	3
UniProt:Q00536 CDK16			0.527	2
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.527	2
UniProt:P33552 CKS2			0.527	3
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.524	2
UniProt:P70168 Kpnb1	5	Kpnb1 [specific granule lumen] (R-MMU-6799646) Kpnb1 [extracellular region] (R-MMU-6806306) Kpnb1 [ficolin-1-rich granule lumen] (R-MMU-6800978) Kpnb1 [nucleoplasm] (R-MMU-180714) Importin subunit beta-1 [cytosol] (R-MMU-2065541)	0.499	4
UniProt:P11440 Cdk1	11	phospho-p-T161-CDK1 [nucleoplasm] (R-MMU-170066) phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (R-MMU-170074) phospho-p-T161-CDK1 [cytosol] (R-MMU-157415) phospho-p-T14,Y15,T161-CDK1 [cytosol] (R-MMU-170071) CDK1 [cytosol] (R-MMU-170075) phospho-p-T14-CDK1 [cytosol] (R-MMU-170064) phospho-p-T14-CDK1 [nucleoplasm] (R-MMU-170045) Cdk1 [nucleoplasm] (R-MMU-1362302) phospho-p-T14,T161-CDK1 [nucleoplasm] (R-MMU-170078) phospho-p-Y4-CDK1 [cytosol] (R-MMU-9836187) CDK1 [endoplasmic reticulum membrane] (R-MMU-264424)	0.499	2
UniProt:Q9UQR0-1 SCML2			0.499	2
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.463	2

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