Reactome | PCSK9 [endoplasmic reticulum lumen]

PCSK9 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8956745

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Proprotein convertase subtilisin/kexin type 9 ecNumber3.4.21.-/ecNumber, PCSK9_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8NBP7 PCSK9

Gene Names

PCSK9, NARC1, PSEC0052

Chain

signal peptide:1-30, propeptide:31-152, chain:153-692

Reference Genes

BioGPS Gene:255738 PCSK9

COSMIC (genes):PCSK9 PCSK9

CTD Gene:255738 PCSK9

dbSNP Gene:255738 PCSK9

ENSEMBL:ENSG00000169174 PCSK9

HGNC:20001 PCSK9

KEGG:hsa:255738 PCSK9

Monarch:255738 PCSK9

NCBI Gene:255738 PCSK9

OMIM:607786 PCSK9

UCSC:Q8NBP7 PCSK9

Reference Transcript

RefSeq:NM_174936.3 PCSK9

Participates

as a member of

FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

p-PCSK9 [endoplasmic reticulum lumen]

PCSK9 [extracellular region]

PCSK9 [lysosomal membrane]

PCSK9 [endolysosome membrane]

Inferred To

Pcsk9 [endoplasmic reticulum lumen] (Mus musculus)

Pcsk9 [endoplasmic reticulum lumen] (Rattus norvegicus)

PCSK9 [endoplasmic reticulum lumen] (Gallus gallus)

PCSK9 [endoplasmic reticulum lumen] (Sus scrofa)

pcsk9 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Cross References

Guide to Pharmacology - Targets

2388

OpenTargets

ENSG00000169174

ENSEMBL

ENSP00000303208, ENST00000302118, ENSG00000169174

ZINC - Substances

PCSK9_HUMAN

ZINC target

Q8NBP7

PRO

Q8NBP7

GlyGen

Q8NBP7

PDB

6OM7, 3GCW, 6OLZ, 2QTW, 6U3X, 6U26, 7ANQ, 6U2F, 4K8R, 6E4Y, 6E4Z, 6U2N, 4OV6, 5VLL, 5VLK, 3H42, 5VL7, 6MV5, 6U2P, 2P4E, 5VLH, 5VLA, 6U36, 2W2Q, 6U38, 5VLP, 4NMX, 3M0C, 2PMW, 6OM0, 3P5B, 5OCA, 6U3I, 3GCX, 2XTJ, 3P5C, 3BPS, 2W2M, 4NE9, 3SQO, 2W2N, 2W2O, 2W2P

HPA

ENSG00000169174-PCSK9

GeneCards

PCSK9

Pharos - Targets

Q8NBP7

Orphanet

PCSK9

ZINC - Predictions - Purchasable

PCSK9_HUMAN

HMDB Protein

HMDBP07935

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01130 LDLR	4	LDLR [plasma membrane] (R-HSA-171053) LDLR [clathrin-coated endocytic vesicle membrane] (R-HSA-171105) LDLR [endosome membrane] (R-HSA-171127) LDLR [endolysosome membrane] (R-HSA-6784818)	0.676	10
UniProt:P08253 MMP2	5	MMP2(110-660) [extracellular region] (R-HSA-381456) MMP2(30-660) [extracellular region] (R-HSA-1604364) MMP2(30-66) [extracellular region] (R-HSA-1604347) MMP2(67-660) [extracellular region] (R-HSA-1604345) MMP2(67-109) [extracellular region] (R-HSA-1604371)	0.618	4
UniProt:P07355 ANXA2	6	ANXA2 [azurophil granule lumen] (R-HSA-6798766) ANXA2 [extracellular region] (R-HSA-6806242) p-S26-ANXA2 [cytosol] (R-HSA-9865163) p-Y24,S26-ANXA2 [cytosol] (R-HSA-9865224) ANXA2 [cytosol] (R-HSA-5263667) ANXA2 [external side of plasma membrane] (R-HSA-5336164)	0.61	7
IntAct:EBI-8785901 ANXA2			0.524	2

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