Reactome | Ldlrap1 [clathrin-coated endocytic vesicle membrane]

Ldlrap1 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-RNO-8869097

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

LDLRAP1, D3ZAR1

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Ldlrap1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Ldlrap1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Ldlrap1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Ldlrap1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Ldlrap1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Ldlrap1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Ldlrap1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Ldlrap1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Ldlrap1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Ldlrap1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D3ZAR1

Gene Names

Ldlrap1

Reference Genes

ENSEMBL:ENSRNOG00000000151

UCSC:D3ZAR1 Ldlrap1

Participates

as a member of

DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

Other forms of this molecule

Ldlrap1 [plasma membrane]

Inferred From

LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

PRO

D3ZAR1

RGD

1563417

PDB

3SO6

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01130 LDLR	4	LDLR [endolysosome membrane] (R-HSA-6784818) LDLR [endosome membrane] (R-HSA-171127) LDLR [clathrin-coated endocytic vesicle membrane] (R-HSA-171105) LDLR [plasma membrane] (R-HSA-171053)	0.558	3
UniProt:P98158-PRO_0000017322 LRP2			0.508	3

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