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APOB(28-2179) [clathrin-coated endocytic vesicle membrane]
Stable Identifier
R-HSA-174788
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
clathrin-coated endocytic vesicle membrane
Synonyms
apoB-48, apolipoprotein B-48
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein clearance (Homo sapiens)
Chylomicron clearance (Homo sapiens)
chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane] (Homo sapiens)
chylomicron remnant:apoE:LDLR complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
chylomicron remnant:apoE complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
chylomicron remnant [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ApoB-48:TG:PL complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
APOB(28-2179) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Homo sapiens)
chylomicron remnant:apoE:LDLR complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
chylomicron remnant:apoE complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
chylomicron remnant [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ApoB-48:TG:PL complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
APOB(28-2179) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04114 APOB
Gene Names
APOB
Chain
signal peptide:1-27, chain:28-4563, chain:28-2179
Reference Genes
BioGPS Gene:338 APOB
COSMIC (genes):APOB APOB
CTD Gene:338 APOB
dbSNP Gene:338 APOB
ENSEMBL:ENSG00000084674 APOB
ENSEMBL_homo_sapiens_GENE:ENSG00000084674.15 APOB
HGNC:603 APOB
KEGG Gene (Homo sapiens):338 APOB
Monarch:338 APOB
NCBI Gene:338 APOB
OMIM:107730 APOB
UCSC:P04114 APOB
Reference Transcript
RefSeq:NM_000384.2 APOB
Other Identifiers
11724530_a_at
11749631_a_at
11758033_s_at
16895014
205108_PM_s_at
205108_s_at
223579_PM_s_at
223579_s_at
2543164
2543165
2543166
2543167
2543168
2543169
2543170
2543171
2543172
2543173
2543174
2543175
2543176
2543177
2543178
2543179
2543180
2543181
2543182
2543183
2543184
2543185
2543186
2543189
2543190
2543193
2543194
2543195
2543196
2543197
2543198
2543199
2543200
2543201
2543202
2543203
2543204
2543205
2543207
2543208
2543212
2543215
2543216
2543217
261_s_at
338
35332_at
8050619
A_23_P79591
GE59661
GO:0001701
GO:0005215
GO:0005319
GO:0005515
GO:0005543
GO:0005576
GO:0005615
GO:0005737
GO:0005764
GO:0005768
GO:0005769
GO:0005773
GO:0005783
GO:0005788
GO:0005789
GO:0005790
GO:0005811
GO:0005829
GO:0005886
GO:0006629
GO:0006642
GO:0006869
GO:0007018
GO:0007283
GO:0007399
GO:0008201
GO:0008202
GO:0008203
GO:0008289
GO:0009566
GO:0009615
GO:0009791
GO:0010008
GO:0010628
GO:0010744
GO:0010884
GO:0010886
GO:0016042
GO:0019433
GO:0022414
GO:0030154
GO:0030163
GO:0030301
GO:0030317
GO:0030669
GO:0031410
GO:0031904
GO:0033344
GO:0034359
GO:0034360
GO:0034361
GO:0034362
GO:0034363
GO:0034374
GO:0034379
GO:0034383
GO:0035473
GO:0042157
GO:0042158
GO:0042159
GO:0042627
GO:0042632
GO:0042953
GO:0043025
GO:0043202
GO:0043226
GO:0043231
GO:0045540
GO:0048844
GO:0048856
GO:0048870
GO:0050750
GO:0051649
GO:0061024
GO:0065003
GO:0070062
GO:0070971
GO:0071682
GO:0120009
GO:0120020
HMNXSV003046817
ILMN_1664024
M19828_s_at
PH_hs_0023426
TC02001628.hg
TC02004093.hg
TC02004094.hg
TC02004095.hg
g4502152_3p_a_at
g7770246_3p_s_at
Participates
as a component of
ApoB-48:TG:PL complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
APOB(28-2179) [cytosol]
APOB(28-2179) [early endosome]
APOB(28-4563) [lysosomal lumen]
APOB(28-2179) [endosome lumen]
APOB(28-2179) [endosome membrane]
APOB(28-4563) [plasma membrane]
APOB(28-4563) [clathrin-coated endocytic vesicle membrane]
APOB(28-4563) [endosome lumen]
APOB(28-4563) [endosome membrane]
APOB(28-2179) [plasma membrane]
APOB(28-2179) [endoplasmic reticulum lumen]
APOB(28-2179) [extracellular region]
APOB(28-2179) [endoplasmic reticulum membrane]
APOB(28-4563) [smooth endoplasmic reticulum]
10xdHF-10xglutamyl semialdehyde (Pro)-6xL-tyrosine residue-3xOxoH-2xmodified L-lysine residue-N'-formyl-L-kynurenine-APOB(28-4563) [endocytic vesicle lumen]
APOB(28-4563) [endocytic vesicle lumen]
AcK-APOB(28-4563) [endocytic vesicle lumen]
AcK-APOB(28-4563) [extracellular region]
p-APOB(28-4563) [endoplasmic reticulum lumen]
APOB(28-4563) [endoplasmic reticulum membrane]
10xdHF-10xglutamyl semialdehyde (Pro)-6xL-tyrosine residue-3xOxoH-2xmodified L-lysine residue-N'-formyl-L-kynurenine-APOB(28-4563) [extracellular region]
APOB(28-4563) [extracellular region]
Inferred To
Apob [clathrin-coated endocytic vesicle membrane]
(Mus musculus)
Apob [clathrin-coated endocytic vesicle membrane]
(Rattus norvegicus)
APOB [clathrin-coated endocytic vesicle membrane]
(Bos taurus)
APOB [clathrin-coated endocytic vesicle membrane]
(Canis familiaris)
APOB [clathrin-coated endocytic vesicle membrane]
(Sus scrofa)
Cross References
RefSeq
NP_000375.2
OpenTargets
ENSG00000084674
ZINC - Substances
APOB_HUMAN
GeneCards
P04114
HPA
ENSG00000084674-APOB
Ensembl
ENSP00000233242
,
ENSG00000084674
,
ENST00000233242
ZINC target
P04114
PRO
P04114
Pharos - Targets
P04114
ZINC - Predictions - Purchasable
APOB_HUMAN
Orphanet
15938
HMDB Protein
HMDBP02081
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P55157 MTTP
1
MTTP [endoplasmic reticulum lumen]
(R-HSA-174688)
0.697
4
UniProt:Q9Y679 AUP1
0.612
5
UniProt:P01130 LDLR
4
LDLR [endolysosome membrane]
(R-HSA-6784818)
LDLR [endosome membrane]
(R-HSA-171127)
LDLR [clathrin-coated endocytic vesicle membrane]
(R-HSA-171105)
LDLR [plasma membrane]
(R-HSA-171053)
0.558
4
UniProt:Q9NY59 SMPD3
1
SMPD3 [plasma membrane]
(R-HSA-1606265)
0.527
2
UniProt:Q99732 LITAF
0.527
2
UniProt:Q9H8X9 ZDHHC11
1
ZDHHC11 [Golgi membrane]
(R-HSA-9774147)
0.527
2
UniProt:Q9GZM5 YIPF3
0.527
3
UniProt:Q0GE19 NTCP7
0.527
2
UniProt:P0DTD1-PRO_0000449624 REP
0.527
2
UniProt:P04844 RPN2
1
RPN2 [endoplasmic reticulum membrane]
(R-HSA-264937)
0.527
2
UniProt:P55072 VCP
8
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [cytosol]
(R-HSA-1181251)
0.527
2
IntAct:EBI-25412519 CHLAE
0.499
2
UniProt:P29991-PRO_0000037946
0.488
3
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