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PCSK9 [lysosomal membrane]
Stable Identifier
R-HSA-8855128
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
Proprotein convertase subtilisin/kexin type 9 ecNumber3.4.21.-/ecNumber, PCSK9_HUMAN
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein clearance (Homo sapiens)
VLDLR internalisation and degradation (Homo sapiens)
VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Homo sapiens)
VLDL:PCSK9:Clathrin:AP2 [lysosomal membrane] (Homo sapiens)
VLDL:PCSK9 [lysosomal membrane] (Homo sapiens)
PCSK9 [lysosomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NBP7 PCSK9
Gene Names
PCSK9, NARC1, PSEC0052
Chain
signal peptide:1-30, propeptide:31-152, chain:153-692
Reference Genes
COSMIC (genes):PCSK9 PCSK9
dbSNP Gene:255738 PCSK9
ENSEMBL:ENSG00000169174 PCSK9
Participates
as a component of
VLDL:PCSK9 [lysosomal membrane] (Homo sapiens)
Other forms of this molecule
PCSK9 [endolysosome membrane]
PCSK9 [extracellular region]
p-PCSK9 [endoplasmic reticulum lumen]
PCSK9 [endoplasmic reticulum lumen]
Inferred To
Homologues of PCSK9 [lysosomal membrane]
(Saccharomyces cerevisiae)
Homologues of PCSK9 [lysosomal membrane]
(Schizosaccharomyces pombe)
PRB1 [lysosomal membrane]
(Saccharomyces cerevisiae)
isp6 [lysosomal membrane]
(Schizosaccharomyces pombe)
PCSK9 [lysosomal membrane]
(Gallus gallus)
PCSK9 [lysosomal membrane]
(Sus scrofa)
RRT12 [lysosomal membrane]
(Saccharomyces cerevisiae)
YSP3 [lysosomal membrane]
(Saccharomyces cerevisiae)
Pcsk9 [lysosomal membrane]
(Mus musculus)
Pcsk9 [lysosomal membrane]
(Rattus norvegicus)
Ghost homologue of PCSK9 [lysosomal membrane]
(Bos taurus)
Ghost homologue of PCSK9 [lysosomal membrane]
(Caenorhabditis elegans)
Ghost homologue of PCSK9 [lysosomal membrane]
(Canis familiaris)
Ghost homologue of PCSK9 [lysosomal membrane]
(Dictyostelium discoideum)
Ghost homologue of PCSK9 [lysosomal membrane]
(Drosophila melanogaster)
pcsk9 [lysosomal membrane]
(Xenopus tropicalis)
psp3 [lysosomal membrane]
(Schizosaccharomyces pombe)
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01130 LDLR
4
LDLR [plasma membrane]
(R-HSA-171053)
LDLR [clathrin-coated endocytic vesicle membrane]
(R-HSA-171105)
LDLR [endosome membrane]
(R-HSA-171127)
LDLR [endolysosome membrane]
(R-HSA-6784818)
0.676
10
UniProt:P08253 MMP2
5
MMP2(110-660) [extracellular region]
(R-HSA-381456)
MMP2(30-660) [extracellular region]
(R-HSA-1604364)
MMP2(67-660) [extracellular region]
(R-HSA-1604345)
MMP2(30-66) [extracellular region]
(R-HSA-1604347)
MMP2(67-109) [extracellular region]
(R-HSA-1604371)
0.618
4
UniProt:P07355 ANXA2
6
ANXA2 [azurophil granule lumen]
(R-HSA-6798766)
ANXA2 [extracellular region]
(R-HSA-6806242)
p-S26-ANXA2 [cytosol]
(R-HSA-9865163)
p-Y24,S26-ANXA2 [cytosol]
(R-HSA-9865224)
ANXA2 [external side of plasma membrane]
(R-HSA-5336164)
ANXA2 [cytosol]
(R-HSA-5263667)
0.61
7
IntAct:EBI-8785901 ANXA2
0.524
2
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