Reactome | PCSK9 [endolysosome membrane]

PCSK9 [endolysosome membrane]

Stable Identifier

R-HSA-6784823

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endolysosome membrane

Synonyms

Proprotein convertase subtilisin/kexin type 9 ecNumber3.4.21.-/ecNumber, PCSK9_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8NBP7 PCSK9

Gene Names

PCSK9, NARC1, PSEC0052

Chain

signal peptide:1-30, propeptide:31-152, chain:153-692

Reference Genes

COSMIC (genes):PCSK9 PCSK9

dbSNP Gene:255738 PCSK9

ENSEMBL:ENSG00000169174 PCSK9

Participates

as a component of

PCSK9:LDLR [endolysosome membrane] (Homo sapiens)

Other forms of this molecule

PCSK9 [lysosomal membrane]

PCSK9 [extracellular region]

p-PCSK9 [endoplasmic reticulum lumen]

PCSK9 [endoplasmic reticulum lumen]

Inferred To

Homologues of PCSK9 [endolysosome membrane] (Saccharomyces cerevisiae)

Homologues of PCSK9 [endolysosome membrane] (Schizosaccharomyces pombe)

PCSK9 [endolysosome membrane] (Gallus gallus)

PCSK9 [endolysosome membrane] (Sus scrofa)

YSP3 [endolysosome membrane] (Saccharomyces cerevisiae)

PRB1 [endolysosome membrane] (Saccharomyces cerevisiae)

Pcsk9 [endolysosome membrane] (Mus musculus)

Pcsk9 [endolysosome membrane] (Rattus norvegicus)

isp6 [endolysosome membrane] (Schizosaccharomyces pombe)

psp3 [endolysosome membrane] (Schizosaccharomyces pombe)

RRT12 [endolysosome membrane] (Saccharomyces cerevisiae)

pcsk9 [endolysosome membrane] (Xenopus tropicalis)

Ghost homologue of PCSK9 [endolysosome membrane] (Bos taurus)

Ghost homologue of PCSK9 [endolysosome membrane] (Caenorhabditis elegans)

Ghost homologue of PCSK9 [endolysosome membrane] (Canis familiaris)

Ghost homologue of PCSK9 [endolysosome membrane] (Dictyostelium discoideum)

Ghost homologue of PCSK9 [endolysosome membrane] (Drosophila melanogaster)

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01130 LDLR	4	LDLR [plasma membrane] (R-HSA-171053) LDLR [clathrin-coated endocytic vesicle membrane] (R-HSA-171105) LDLR [endosome membrane] (R-HSA-171127) LDLR [endolysosome membrane] (R-HSA-6784818)	0.676	10
UniProt:P08253 MMP2	5	MMP2(110-660) [extracellular region] (R-HSA-381456) MMP2(30-660) [extracellular region] (R-HSA-1604364) MMP2(67-660) [extracellular region] (R-HSA-1604345) MMP2(30-66) [extracellular region] (R-HSA-1604347) MMP2(67-109) [extracellular region] (R-HSA-1604371)	0.618	4
UniProt:P07355 ANXA2	6	ANXA2 [azurophil granule lumen] (R-HSA-6798766) ANXA2 [extracellular region] (R-HSA-6806242) p-S26-ANXA2 [cytosol] (R-HSA-9865163) p-Y24,S26-ANXA2 [cytosol] (R-HSA-9865224) ANXA2 [cytosol] (R-HSA-5263667) ANXA2 [external side of plasma membrane] (R-HSA-5336164)	0.61	7
IntAct:EBI-8785901 ANXA2			0.524	2

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