SUMOylation of transcription cofactors

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R-HSA-3899300
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Homo sapiens
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SUMO1,2, and 3 are predominantly located in the nucleus and targets of SUMOylation are predominantly nuclear. Transcription cofactors are nuclear proteins that generally do not bind DNA themselves but interact with DNA-bound factors and influence transcription. SUMOylation of transcription cofactors usually inhibits the activity of the cofactor (reviewed in Girdwood et al. 2004, Gill 2005, Lyst and Stancheva 2007, Garcia-Dominguez and Reyes 2009). In the cases of coactivators such as PPARGC1A (PGC-1alpha) this results in decreased transcription; in the cases of corepressors such as MBD1 this results in increased transcription.

Literature References
PubMed ID Title Journal Year
15209380 SUMO and transcriptional regulation

Girdwood, DW, Tatham, MH, Hay, RT

Semin. Cell Dev. Biol. 2004
19616654 SUMO association with repressor complexes, emerging routes for transcriptional control

Reyes, JC, Garcia-Dominguez, M

Biochim. Biophys. Acta 2009
16095902 Something about SUMO inhibits transcription

Gill, G

Curr. Opin. Genet. Dev. 2005
18031228 A role for SUMO modification in transcriptional repression and activation

Stancheva, I, Lyst, MJ

Biochem. Soc. Trans. 2007
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