SUMOylation of DDX5 with SUMO1

Stable Identifier
R-HSA-3900177
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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DDX5 is SUMOylated at lysine-53 with SUMO1 (Mooney et al. 2010, Matafora et al. 2009, Impens et al. 2014). SUMOylation enhances coactivation activity of DDX5, stability of DDX5, and interaction of DDX5 with HDAC1.

Literature References
PubMed ID Title Journal Year
19995069 Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential

Mooney, SM, Grande, JP, Salisbury, JL, Janknecht, R

Biochemistry 2010
19596686 Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition

Matafora, V, D'Amato, A, Mori, S, Blasi, F, Bachi, A

Mol. Cell Proteomics 2009
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Radoshevich, L, Cossart, P, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created