Reactome | PIAS1 SUMOylates SAFB with SUMO1

PIAS1 SUMOylates SAFB with SUMO1

Stable Identifier

R-HSA-4085347

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PIAS1 SUMOylates SAFB at lysine-231 and lysine-294 with SUMO1 (Garee et al. 2011). SUMOylation of SAFB is required for co-repressor activity of SAFB at promoters regulated by the estrogen receptor (ER). In contrast, SUMOylated SAFB increases transcription of genes encoding ribosomal proteins (Liu 2015).

Literature References

PubMed ID	Title	Journal	Year
21527249	Co-repressor activity of scaffold attachment factor B1 requires sumoylation Garee, JP, Meyer, R, Oesterreich, S	Biochem. Biophys. Res. Commun.	2011
25800734	The chromatin scaffold protein SAFB1 localizes SUMO-1 to the promoters of ribosomal protein genes to facilitate transcription initiation and splicing Liu, HW, Banerjee, T, Guan, X, Freitas, MA, Parvin, JD	Nucleic Acids Res.	2015