SUMOylation of HIPK2 with SUMO1

Stable Identifier
R-HSA-4090284
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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HIPK2 is SUMOylated at lysine-32 with SUMO1. (Lysine-25 is cited by Hofmann et al. 2005 and Gresko et al. 2005, however the sequence motif listed in Hoffmann et al. 2005 corresponds to lysine-32 of the UniProt reference protein. An alternative isoform having lysine-25 is listed as accession AAG35710 in GenBank.) SUMOylation of HIPK2 disrupts interaction of HIPK2 with GROUCHO corepressor, inhibits JNK activation, and inhibits p53-independent antiproliferative function.

Literature References
PubMed ID Title Journal Year
15958389 Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification

Hofmann, TG, Jaffray, E, Stollberg, N, Hay, RT, Will, H

J. Biol. Chem. 2005
15766567 Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability

Gresko, E, Möller, A, Roscic, A, Schmitz, ML

Biochem. Biophys. Res. Commun. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created