CBX4, UHRF2 SUMOylate ZNF131 with SUMO1

Stable Identifier
R-HSA-3296126
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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CBX4, UHRF2 SUMOylate ZNF131 with SUMO1
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CBX4 (Pc2) and UHRF2 are able to SUMOylate ZNF131 on lysine-601 (lysine-567 in the isoform in Oh and Chung 2012, Oh and Chung 2013) . SUMOylation of ZNF131 increases the inhibition of ERalpha signaling by ZNF131 through suppression of ERalpha homodimerization.

Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

SUMO transferase activity of CBX4, UHRF2 [nucleoplasm]

Physical Entity
CBX4, UHRF2 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Bos taurus)
CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Danio rerio)
CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Gallus gallus)
CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Mus musculus)
CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Rattus norvegicus)
CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Xenopus tropicalis)
Authored
May, B  (2013-04-13)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-04-18)
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