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CBX4, UHRF2 SUMOylate ZNF131 with SUMO1
Stable Identifier
R-HSA-3296126
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Homo sapiens)
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CBX4 (Pc2) and UHRF2 are able to SUMOylate ZNF131 on lysine-601 (lysine-567 in the isoform in Oh and Chung 2012, Oh and Chung 2013) . SUMOylation of ZNF131 increases the inhibition of ERalpha signaling by ZNF131 through suppression of ERalpha homodimerization.
Literature References
PubMed ID
Title
Journal
Year
23404503
UHRF2, a Ubiquitin E3 Ligase, Acts as a Small Ubiquitin-like Modifier E3 Ligase for Zinc Finger Protein 131
Chung, KC
,
Oh, Y
J. Biol. Chem.
2013
22467880
Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling
Chung, KC
,
Oh, Y
J. Biol. Chem.
2012
Participants
Input
SUMO1:C93-UBE2I [nucleoplasm]
(Homo sapiens)
ZNF131 [nucleoplasm]
(Homo sapiens)
Output
monoSUMO1-K601-ZNF131 [nucleoplasm]
(Homo sapiens)
UBE2I [nucleoplasm]
(Homo sapiens)
Participates
as an event of
SUMOylation of transcription cofactors (Homo sapiens)
Catalyst Activity
SUMO transferase activity of CBX4, UHRF2 [nucleoplasm]
Physical Entity
CBX4, UHRF2 [nucleoplasm]
(Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Bos taurus)
CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Gallus gallus)
CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Mus musculus)
CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Rattus norvegicus)
CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Xenopus tropicalis)
Authored
May, B (2013-04-13)
Reviewed
Niskanen, E (2018-05-09)
Niskanen, E (2018-08-08)
Created
May, B (2013-04-18)
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