SUMOylation of EP300 with SUMO1

Stable Identifier
R-HSA-3899291
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SUMOylation of EP300 with SUMO1
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EP300 (p300) is SUMOylated at lysine-1020 and lysine-1024 with SUMO1 (Girdwood et al. 2003). SUMOylation of EP300 alleviates transcriptional repression caused by the CRD1 domain.

Literature References
PubMed ID Title Journal Year
12718889 P300 transcriptional repression is mediated by SUMO modification

Perkins, ND, Hay, RT, Snowden, AW, Thain, A, Vaughan, OA, Girdwood, D, Bumpass, D, Anderson, LA, Garcia-Wilson, E

Mol. Cell 2003
Participants
Input
Output
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as an event of
Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]

Physical Entity
SUMO1:C93-UBE2I [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
SUMOylation of EP300 with SUMO1 (Bos taurus)
SUMOylation of EP300 with SUMO1 (Caenorhabditis elegans)
SUMOylation of EP300 with SUMO1 (Danio rerio)
SUMOylation of EP300 with SUMO1 (Gallus gallus)
SUMOylation of EP300 with SUMO1 (Mus musculus)
SUMOylation of EP300 with SUMO1 (Xenopus tropicalis)
Authored
May, B  (2013-07-09)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-07-12)
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