Reactome | SUMOylation of NPM1 with SUMO1

SUMOylation of NPM1 with SUMO1

Stable Identifier

R-HSA-4086088

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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NPM1 (Nucleophosmin, B23) is SUMOylated at lysine-263 with SUMO1 (Liu et al. 2007). SUMOylation enhances binding of NPM1 to Rb and enhances nuclear residency of NPM1.

Literature References

PubMed ID	Title	Journal	Year
17535915	Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival Liu, X, Shinmura, K, Kang, S, Ma, Z, Jang, SW, Ye, K, Liu, Z, Fukasawa, K, Chen, J, Dong, S	Proc. Natl. Acad. Sci. U.S.A.	2007