PRC1 SUMOylates CTBP1 with SUMO2,3

Stable Identifier
R-HSA-3108203
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PRC1 SUMOylates CTBP1 with SUMO2,3
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CBX4 (Pc2) via its SUMO-interacting motifs recruits both CTBP1 and SUMO2,3:UBE2I (SUMO1:UBC9) to polycomb bodies where CTBP1 is SUMOylated with SUMO2,3 at lysine-428, as inferred from SUMOylation with SUMO1 (Merrill et al. 2010, Yang and Sharrocks 2010).
Literature References
PubMed ID Title Journal Year
20176810 The SUMO E3 ligase activity of Pc2 is coordinated through a SUMO interaction motif

Yang, SH, Sharrocks, AD

Mol. Cell. Biol. 2010
20098713 A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity

Yang, SH, Melhuish, TA, Merrill, JC, Sharrocks, AD, Wotton, D, Kagey, MH

PLoS ONE 2010
Participants
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Output
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as an event of
Catalyst Activity

SUMO transferase activity of PRC1 complex [nucleoplasm]

Physical Entity
PRC1 complex [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PRC1 SUMOylates CTBP1 with SUMO2,3 (Bos taurus)
PRC1 SUMOylates CTBP1 with SUMO2,3 (Danio rerio)
PRC1 SUMOylates CTBP1 with SUMO2,3 (Drosophila melanogaster)
PRC1 SUMOylates CTBP1 with SUMO2,3 (Gallus gallus)
PRC1 SUMOylates CTBP1 with SUMO2,3 (Mus musculus)
PRC1 SUMOylates CTBP1 with SUMO2,3 (Rattus norvegicus)
PRC1 SUMOylates CTBP1 with SUMO2,3 (Sus scrofa)
PRC1 SUMOylates CTBP1 with SUMO2,3 (Xenopus tropicalis)
Authored
May, B  (2013-02-06)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-02-10)
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