Reactome | SUMOylation of NPM1 with SUMO2,3

SUMOylation of NPM1 with SUMO2,3

Stable Identifier

R-HSA-4086059

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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NPM1 (Nucleophosmin, B23) is SUMOylated at lysine-263 with SUMO2,3 (Liu et al. 2007, Blomster et al. 2009, Hendriks et al. 2014). SUMOylation enhances binding of NPM1 to Rb and enhances nuclear residency of NPM1.

Literature References

PubMed ID	Title	Journal	Year
17535915	Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival Liu, X, Liu, Z, Jang, SW, Ma, Z, Shinmura, K, Kang, S, Dong, S, Chen, J, Fukasawa, K, Ye, K	Proc. Natl. Acad. Sci. U.S.A.	2007
25218447	Uncovering global SUMOylation signaling networks in a site-specific manner Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC	Nat. Struct. Mol. Biol.	2014
19240082	Novel proteomics strategy brings insight into the prevalence of SUMO-2 target sites Blomster, HA, Hietakangas, V, Wu, J, Kouvonen, P, Hautaniemi, S, Sistonen, L	Mol. Cell Proteomics	2009