SUMOylation of MKL1 with SUMO1

Stable Identifier
R-HSA-3900070
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SUMOylation of MKL1 with SUMO1
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MKL1 is SUMOylated with SUMO1 at lysine-499, lysine-576, and lysine-624 (Nakagawa and Kuzumaki 2005) SUMOylation represses transcriptional activity of MKL1. MKL1 is a coactivator of SRF.

Literature References
PubMed ID Title Journal Year
16098147 Transcriptional activity of megakaryoblastic leukemia 1 (MKL1) is repressed by SUMO modification

Kuzumaki, N, Nakagawa, K

Genes Cells 2005
Participants
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Output
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as an event of
Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]

Physical Entity
SUMO1:C93-UBE2I [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
SUMOylation of MKL1 with SUMO1 (Bos taurus)
SUMOylation of MKL1 with SUMO1 (Danio rerio)
SUMOylation of MKL1 with SUMO1 (Gallus gallus)
SUMOylation of MKL1 with SUMO1 (Mus musculus)
SUMOylation of MKL1 with SUMO1 (Rattus norvegicus)
SUMOylation of MKL1 with SUMO1 (Xenopus tropicalis)
Authored
May, B  (2013-07-12)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-07-15)
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