PIAS1 SUMOylates DDX5 with SUMO2

Stable Identifier
R-HSA-3900194
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PIAS1 SUMOylates DDX5 at lysine-53 with SUMO2 (Jacobs et al. 2007, Hendriks et al. 2014, Impens et al. 2014). SUMOylation reduces the coactivation activity of DDX5 with p53 but enhances coactivation of the estrogen receptor. SUMOylation also increases stability of DDX5 and promotes interaction of DDX5 with HDAC1. DDX5 is a coactivator of p53 (TP53).

Literature References
PubMed ID Title Journal Year
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC

Nat. Struct. Mol. Biol. 2014
17369852 SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1

Jacobs, AM, Nicol, SM, Hislop, RG, Jaffray, EG, Hay, RT, Fuller-Pace, FV

Oncogene 2007
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Radoshevich, L, Cossart, P, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created