Reactome | PIAS1 SUMOylates DDX5 with SUMO2

PIAS1 SUMOylates DDX5 with SUMO2

Stable Identifier

R-HSA-3900194

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PIAS1 SUMOylates DDX5 at lysine-53 with SUMO2 (Jacobs et al. 2007, Hendriks et al. 2014, Impens et al. 2014). SUMOylation reduces the coactivation activity of DDX5 with p53 but enhances coactivation of the estrogen receptor. SUMOylation also increases stability of DDX5 and promotes interaction of DDX5 with HDAC1. DDX5 is a coactivator of p53 (TP53).

Literature References

PubMed ID	Title	Journal	Year
17369852	SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1 Fuller-Pace, FV, Hislop, RG, Jaffray, EG, Jacobs, AM, Nicol, SM, Hay, RT	Oncogene	2007
25218447	Uncovering global SUMOylation signaling networks in a site-specific manner Yang, B, Hendriks, IA, Verlaan-de Vries, M, Vertegaal, AC, D'Souza, RC, Mann, M	Nat. Struct. Mol. Biol.	2014
25114211	Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli Impens, F, Cossart, P, Radoshevich, L, Ribet, D	Proc. Natl. Acad. Sci. U.S.A.	2014