PIAS2-1 SUMOylates PARK7 with SUMO1

Stable Identifier
Reaction [transition]
Homo sapiens
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PIAS2-1 (PIASxalpha) SUMOylates PARK7 (DJ-1) at lysine-130 with SUMO1 (Takahashi et al. 2001, Shinbo et al. 2006). SUMOylation causes PARK7 to be retained in the nucleus where it represses transcription activation by P53 (TP53). A non-SUMOylatable mutant of PARK7 is located in the cytoplasm and fails to repress TP53 (p53) transcriptional activity (Fan et al. 2008).

Literature References
PubMed ID Title Journal Year
18339323 Sumoylation is critical for DJ-1 to repress p53 transcriptional activity

Fei, E, Wu, M, Ren, H, Fan, J, Ying, Z, Jia, N, Jiang, P, Wang, G

FEBS Lett. 2008
15976810 Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities

Niki, T, Seino, C, Ooe, H, Ariga, H, Shinbo, Y, Takahashi-Niki, K, Taira, T, Maita, C, Iguchi-Ariga, SM

Cell Death Differ. 2006
11477070 DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor

Takahashi, K, Niki, T, Seino, C, Ariga, H, Taira, T, Iguchi-Ariga, SM

J. Biol. Chem. 2001
Catalyst Activity

SUMO transferase activity of PIAS2-1 [nucleoplasm]

Orthologous Events
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