PIAS2-1 (PIASxalpha) SUMOylates PARK7 (DJ-1) at lysine-130 with SUMO1 (Takahashi et al. 2001, Shinbo et al. 2006). SUMOylation causes PARK7 to be retained in the nucleus where it represses transcription activation by P53 (TP53). A non-SUMOylatable mutant of PARK7 is located in the cytoplasm and fails to repress TP53 (p53) transcriptional activity (Fan et al. 2008).
Fei, E, Wu, M, Ren, H, Fan, J, Ying, Z, Jia, N, Jiang, P, Wang, G
Niki, T, Seino, C, Ooe, H, Ariga, H, Shinbo, Y, Takahashi-Niki, K, Taira, T, Maita, C, Iguchi-Ariga, SM
Takahashi, K, Niki, T, Seino, C, Ariga, H, Taira, T, Iguchi-Ariga, SM
SUMO transferase activity of PIAS2-1 [nucleoplasm]
© 2023 Reactome