PIAS2-1 SUMOylates PARK7 with SUMO1

Stable Identifier
R-HSA-4085331
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PIAS2-1 (PIASxalpha) SUMOylates PARK7 (DJ-1) at lysine-130 with SUMO1 (Takahashi et al. 2001, Shinbo et al. 2006). SUMOylation causes PARK7 to be retained in the nucleus where it represses transcription activation by P53 (TP53). A non-SUMOylatable mutant of PARK7 is located in the cytoplasm and fails to repress TP53 (p53) transcriptional activity (Fan et al. 2008).

Literature References
PubMed ID Title Journal Year
15976810 Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities

Shinbo, Y, Niki, T, Taira, T, Ooe, H, Takahashi-Niki, K, Maita, C, Seino, C, Iguchi-Ariga, SM, Ariga, H

Cell Death Differ. 2006
18339323 Sumoylation is critical for DJ-1 to repress p53 transcriptional activity

Fan, J, Ren, H, Fei, E, Jia, N, Ying, Z, Jiang, P, Wu, M, Wang, G

FEBS Lett. 2008
11477070 DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor

Takahashi, K, Taira, T, Niki, T, Seino, C, Iguchi-Ariga, SM, Ariga, H

J. Biol. Chem. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS2-1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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