Reactome | PIAS2-1 SUMOylates PARK7 with SUMO1

PIAS2-1 SUMOylates PARK7 with SUMO1

Stable Identifier

R-HSA-4085331

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PIAS2-1 (PIASxalpha) SUMOylates PARK7 (DJ-1) at lysine-130 with SUMO1 (Takahashi et al. 2001, Shinbo et al. 2006). SUMOylation causes PARK7 to be retained in the nucleus where it represses transcription activation by P53 (TP53). A non-SUMOylatable mutant of PARK7 is located in the cytoplasm and fails to repress TP53 (p53) transcriptional activity (Fan et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18339323	Sumoylation is critical for DJ-1 to repress p53 transcriptional activity Fei, E, Wu, M, Ren, H, Fan, J, Ying, Z, Jia, N, Jiang, P, Wang, G	FEBS Lett.	2008
15976810	Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities Niki, T, Seino, C, Ooe, H, Ariga, H, Shinbo, Y, Takahashi-Niki, K, Taira, T, Maita, C, Iguchi-Ariga, SM	Cell Death Differ.	2006
11477070	DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor Takahashi, K, Niki, T, Seino, C, Ariga, H, Taira, T, Iguchi-Ariga, SM	J. Biol. Chem.	2001