SUMOylation of NCOA1 with SUMO1

Stable Identifier
R-HSA-4085296
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SUMOylation of SRC1 with SUMO1
ReviewStatus
5/5
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SUMOylation of NCOA1 with SUMO1
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NCOA1 (SRC1) is SUMOylated at lysine-732 and lysine-774 with SUMO1 (Chauchereau et al. 2003). SUMOylation enhances interaction between NCOA1 and the progesterone receptor and causes NCOA1 to be retained in the nucleus.
Literature References
PubMed ID Title Journal Year
12529333 Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1

Chauchereau, A, Quesne, M, Guiochon-Mantel, A, Milgrom, E, Amazit, L

J. Biol. Chem. 2003
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Output
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as an event of
Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]

Physical Entity
SUMO1:C93-UBE2I [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
SUMOylation of NCOA1 with SUMO1 (Bos taurus)
SUMOylation of NCOA1 with SUMO1 (Gallus gallus)
SUMOylation of NCOA1 with SUMO1 (Mus musculus)
SUMOylation of NCOA1 with SUMO1 (Rattus norvegicus)
SUMOylation of NCOA1 with SUMO1 (Sus scrofa)
Authored
May, B  (2013-07-25)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-08-03)
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