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PIAS1 SUMOylates SAFB with SUMO2,3
Stable Identifier
R-HSA-4085372
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
PIAS1 SUMOylates SAFB with SUMO2,3 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PIAS1 SUMOylates SAFB at lysine 231 and lysine 294 with SUMO2,3 (Garee et al. 2011). SUMOylation of SAFB is required for co-repressor activity.
Literature References
PubMed ID
Title
Journal
Year
21527249
Co-repressor activity of scaffold attachment factor B1 requires sumoylation
Oesterreich, S
,
Garee, JP
,
Meyer, R
Biochem. Biophys. Res. Commun.
2011
Participants
Input
SAFB [nucleoplasm]
(Homo sapiens)
x 4
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm]
(Homo sapiens)
Output
polySUMO2,3-K231,K294-SAFB [nucleoplasm]
(Homo sapiens)
x 4
UBE2I [nucleoplasm]
(Homo sapiens)
Participates
as an event of
SUMOylation of transcription cofactors (Homo sapiens)
Catalyst Activity
SUMO transferase activity of PIAS1 [nucleoplasm]
Physical Entity
PIAS1 [nucleoplasm]
(Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS1 SUMOylates SAFB with SUMO2,3 (Bos taurus)
PIAS1 SUMOylates SAFB with SUMO2,3 (Drosophila melanogaster)
PIAS1 SUMOylates SAFB with SUMO2,3 (Gallus gallus)
PIAS1 SUMOylates SAFB with SUMO2,3 (Mus musculus)
PIAS1 SUMOylates SAFB with SUMO2,3 (Rattus norvegicus)
PIAS1 SUMOylates SAFB with SUMO2,3 (Sus scrofa)
Authored
May, B (2013-08-03)
Reviewed
Niskanen, E (2018-05-09)
Niskanen, E (2018-08-08)
Created
May, B (2013-08-05)
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