PIAS1,3 SUMOylate MBD1 with SUMO1

Stable Identifier
R-HSA-4090288
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PIAS1,3 SUMOylate MBD1 with SUMO1
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PIAS1,3 SUMOylates MBD1 at lysine-499 and lysine-538 of the reference sequence (lysine-450 and lysine-489 of isoform 5) with SUMO1 (Lyst et al. 2006, Uchimura et al. 2006). SUMOylated MBD1 does not form a complex with SETDB1 and does not repress transcription.

Literature References
PubMed ID Title Journal Year
17066076 Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins

Stancheva, I, Lyst, MJ, Nan, X

EMBO J. 2006
16757475 Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation

Uwada, J, Nakao, M, Tachibana, T, Uchimura, Y, Saitoh, H, Sugahara, S, Ichimura, T

J. Biol. Chem. 2006
Participants
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as an event of
Catalyst Activity

SUMO transferase activity of PIAS1,3 [nucleoplasm]

Physical Entity
PIAS1,3 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS1,3 SUMOylate MBD1 with SUMO1 (Bos taurus)
PIAS1,3 SUMOylate MBD1 with SUMO1 (Mus musculus)
PIAS1,3 SUMOylate MBD1 with SUMO1 (Rattus norvegicus)
Authored
May, B  (2013-08-07)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-08-14)
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