Reactome | PIAS1,3 SUMOylate MBD1 with SUMO1

PIAS1,3 SUMOylate MBD1 with SUMO1

Stable Identifier

R-HSA-4090288

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PIAS1,3 SUMOylates MBD1 at lysine-499 and lysine-538 of the reference sequence (lysine-450 and lysine-489 of isoform 5) with SUMO1 (Uchimura et al. 2006, Hendriks et al. 2014, Hendriks et al. 2017, Breuker and Pichler 2019). SUMOylation of MBD1 enhances its interaction with MCAF1 (Uchimura et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
28112733	Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation Nielsen, ML, Lyon, D, Jensen, LJ, Hendriks, IA, Young, C, Vertegaal, AC	Nat Struct Mol Biol	2017
16757475	Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation Uwada, J, Nakao, M, Tachibana, T, Uchimura, Y, Saitoh, H, Sugahara, S, Ichimura, T	J. Biol. Chem.	2006
25218447	Uncovering global SUMOylation signaling networks in a site-specific manner Yang, B, Hendriks, IA, Verlaan-de Vries, M, Vertegaal, AC, D'Souza, RC, Mann, M	Nat. Struct. Mol. Biol.	2014
31256382	Analysis of Sumoylation Pichler, A, Breucker, J	Methods Mol Biol	2019