PRC1 SUMOylates CASP8AP2 with SUMO1

Stable Identifier
R-HSA-3927824
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Pc2 SUMOylates FLASH
ReviewStatus
5/5
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PRC1 SUMOylates CASP8AP2 with SUMO1
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The CBX3 component of PRC1 SUMOylates CASP8AP2 (FLASH) at lysine-1813 with SUMO1 (Alm-Kristiansen et al. 2009). SUMOylation enhances the transcriptional coactivation activity of CASP8AP2. SUMOylation also appears to trigger proteasomal degradation of CASP8AP2 (Vennemann and Hofmann 2013).
Literature References
PubMed ID Title Journal Year
23673342 SUMO regulates proteasome-dependent degradation of FLASH/Casp8AP2

Vennemann, A, Hofmann, TG

Cell Cycle 2013
19615980 SUMO modification regulates the transcriptional activity of FLASH

Alm-Kristiansen, AH, Norman, IL, Matre, V, Gabrielsen, OS

Biochem. Biophys. Res. Commun. 2009
Participants
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Output
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as an event of
Catalyst Activity

SUMO transferase activity of PRC1 complex [nucleoplasm]

Physical Entity
PRC1 complex [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PRC1 SUMOylates CASP8AP2 with SUMO1 (Bos taurus)
PRC1 SUMOylates CASP8AP2 with SUMO1 (Danio rerio)
PRC1 SUMOylates CASP8AP2 with SUMO1 (Gallus gallus)
PRC1 SUMOylates CASP8AP2 with SUMO1 (Mus musculus)
PRC1 SUMOylates CASP8AP2 with SUMO1 (Rattus norvegicus)
PRC1 SUMOylates CASP8AP2 with SUMO1 (Sus scrofa)
Authored
May, B  (2013-07-17)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-07-21)
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