Reactome | PIAS1,4 SUMOylate CASP8AP2 with SUMO1

PIAS1,4 SUMOylate CASP8AP2 with SUMO1

Stable Identifier

R-HSA-5228521

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PIAS1,PIAS4 SUMOylate FLASH

ReviewStatus

5/5

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PIAS1, PIAS4 SUMOylate CASP8AP2 (FLASH) at lysine-1813 with SUMO1 (Alm-Kristiansen et al. 2009, Alm-Kristiansen et al. 2011). SUMOylation enhances the transcriptional coactivation activity of CASP8AP2. As inferred from mouse homologs, SUMOylation also appears to trigger proteasomal degradation of CASP8AP2 (Vennemann and Hofmann 2013).

Literature References

PubMed ID	Title	Journal	Year
23673342	SUMO regulates proteasome-dependent degradation of FLASH/Casp8AP2 Vennemann, A, Hofmann, TG	Cell Cycle	2013
21338522	PIAS1 interacts with FLASH and enhances its co-activation of c-Myb Alm-Kristiansen, AH, Lorenzo, PI, Molværsmyr, AK, Matre, V, Ledsaak, M, Sæther, T, Gabrielsen, OS	Mol. Cancer	2011
19615980	SUMO modification regulates the transcriptional activity of FLASH Alm-Kristiansen, AH, Norman, IL, Matre, V, Gabrielsen, OS	Biochem. Biophys. Res. Commun.	2009