AKT-phosphorylated FOXO3 translocates to cytosol

Stable Identifier
R-HSA-9699581
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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AKT-mediated phosphorylation of FOXO3 downstream of FLT3 and FLT3-ITD signaling promotes its inactivation and translocation to the cytosol, interfering with its pro-apoptotic transcription factor activity as assessed by protein and RNA levels of BCL2L11/BIM and CDKN1B/p27 KIP (Scheijen et al, 2004; reviewed in Burgering, 2008; Yadav et al, 2018; Kazi and Ronnstrand, 2019)

Literature References
PubMed ID Title Journal Year
29309929 FoxO transcription factors in cancer metabolism

Yadav, RK, Chauhan, AS, Zhuang, L, Gan, B

Semin. Cancer Biol. 2018
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
18391968 A brief introduction to FOXOlogy

Burgering, BM

Oncogene 2008
14981546 FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins

Scheijen, B, Ngo, HT, Kang, H, Griffin, JD

Oncogene 2004
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