AKT-mediated phosphorylation of FOXO3 downstream of FLT3 and FLT3-ITD signaling promotes its inactivation and translocation to the cytosol, interfering with its pro-apoptotic transcription factor activity as assessed by protein and RNA levels of BCL2L11/BIM and CDKN1B/p27 KIP (Scheijen et al, 2004; reviewed in Burgering, 2008; Yadav et al, 2018; Kazi and Ronnstrand, 2019)
Kazi, JU, Rönnstrand, L
Zhuang, L, Yadav, RK, Chauhan, AS, Gan, B
Burgering, BM
Griffin, JD, Scheijen, B, Kang, H, Ngo, HT
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