Reactome | AKT-phosphorylated FOXO3 translocates to cytosol

AKT-phosphorylated FOXO3 translocates to cytosol

Stable Identifier

R-HSA-9699581

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

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AKT-phosphorylated FOXO3 translocates to cytosol

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AKT-mediated phosphorylation of FOXO3 downstream of FLT3 and FLT3-ITD signaling promotes its inactivation and translocation to the cytosol, interfering with its pro-apoptotic transcription factor activity as assessed by protein and RNA levels of BCL2L11/BIM and CDKN1B/p27 KIP (Scheijen et al, 2004; reviewed in Burgering, 2008; Yadav et al, 2018; Kazi and Ronnstrand, 2019)

Literature References

PubMed ID	Title	Journal	Year
31066629	FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications Kazi, JU, Rönnstrand, L	Physiol. Rev.	2019
29309929	FoxO transcription factors in cancer metabolism Zhuang, L, Yadav, RK, Chauhan, AS, Gan, B	Semin. Cancer Biol.	2018
18391968	A brief introduction to FOXOlogy Burgering, BM	Oncogene	2008
14981546	FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins Griffin, JD, Scheijen, B, Kang, H, Ngo, HT	Oncogene	2004