Reactome | AKT-phosphorylated FOXO3 translocates to cytosol

AKT-phosphorylated FOXO3 translocates to cytosol

Stable Identifier

R-HSA-9624527

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

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AKT-phosphorylated FOXO3 translocates to cytosol

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AKT-mediated phosphorylation of FOXO3 downstream of estrogen stimulation promotes its inactivation and translocation to the cytosol, interfering with its pro-apoptotic transcription factor activity (Richards et al, 2002; Brunet et al, 1999; reviewed in Levin, 2005; Burgering, 2008).

Literature References

PubMed ID	Title	Journal	Year
10102273	Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor Brunet, A, Bonni, A, Zigmond, MJ, Lin, MZ, Juo, P, Hu, LS, Anderson, MJ, Arden, KC, Blenis, J, Greenberg, ME	Cell	1999
18391968	A brief introduction to FOXOlogy Burgering, BM	Oncogene	2008
11875118	Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary: evidence for regulation by IGF-I, estrogen, and the gonadotropins Richards, JS, Sharma, SC, Falender, AE, Lo, YH	Mol. Endocrinol.	2002
15705661	Integration of the extranuclear and nuclear actions of estrogen Levin, ER	Mol. Endocrinol.	2005