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FGFR3b [plasma membrane]
Stable Identifier
R-HSA-189911
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
FGFR3-2, Fibroblast growth factor receptor 3b, FGR3_HUMAN, FGFR3 isoform 2
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR3 (Homo sapiens)
FGFR3 ligand binding and activation (Homo sapiens)
FGFR3b ligand binding and activation (Homo sapiens)
Autocatalytic phosphorylation of FGFR3b (Homo sapiens)
FGFR3b homodimer bound to FGF [plasma membrane] (Homo sapiens)
FGFR3b homodimer [plasma membrane] (Homo sapiens)
FGFR3b [plasma membrane] (Homo sapiens)
FGFR3b binds to FGF (Homo sapiens)
FGFR3b [plasma membrane] (Homo sapiens)
FGFR3b homodimer bound to FGF [plasma membrane] (Homo sapiens)
FGFR3b homodimer [plasma membrane] (Homo sapiens)
FGFR3b [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22607-2 FGFR3
Gene Names
FGFR3, JTK4
Other Identifiers
0002940050
0003850722
11717969_a_at
11755786_a_at
16964027
204379_s_at
204380_s_at
2261
2715017
2715018
2715019
2715026
2715027
2715028
2715029
2715030
2715031
2715032
2715033
2715039
2715040
2715041
2715042
2715043
2715045
2715046
2715047
2715048
2715049
2715051
2715053
2715054
2715056
2715057
2715058
31805_at
8093518
A_14_P132738
A_23_P212830
A_23_P500501
GE577766
GE58034
GO:0000165
GO:0000166
GO:0001501
GO:0001958
GO:0002062
GO:0003416
GO:0003674
GO:0004672
GO:0004713
GO:0004714
GO:0005007
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005622
GO:0005634
GO:0005737
GO:0005783
GO:0005794
GO:0005886
GO:0005887
GO:0005925
GO:0006464
GO:0006468
GO:0006629
GO:0006915
GO:0007165
GO:0007169
GO:0007267
GO:0007275
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008543
GO:0009986
GO:0010518
GO:0016020
GO:0016021
GO:0016301
GO:0016310
GO:0016740
GO:0017134
GO:0018108
GO:0021700
GO:0030133
GO:0030154
GO:0030282
GO:0031410
GO:0032991
GO:0033674
GO:0035988
GO:0040007
GO:0042531
GO:0042802
GO:0043167
GO:0043226
GO:0043235
GO:0043410
GO:0043552
GO:0046777
GO:0048640
GO:0048856
GO:0051897
GO:0060349
GO:0070374
GO:0070977
GO:1902178
ILMN_1651966
ILMN_1723123
M64347_at
TC04000029.hg
TC04001856.hg
g13112046_3p_a_at
g182568_3p_a_at
Participant Of
input
FGFR3b binds to FGF
hasComponent
FGFR3b homodimer [plasma membrane]
Other forms of this molecule
FGFR3b G697C [plasma membrane]
FGFR3b S249C [plasma membrane]
p-6Y-FGFR3b S249C mutant [plasma membrane]
p-6Y-FGFR3b G697C [plasma membrane]
p-6Y-FGFR3b [plasma membrane]
Inferred To
Homologues of FGFR3b [plasma membrane] (Drosophila melanogaster)
egl-15 [plasma membrane] (Caenorhabditis elegans)
btl [plasma membrane] (Drosophila melanogaster)
Cad96Ca [plasma membrane] (Drosophila melanogaster)
fgfr3 [plasma membrane] (Danio rerio)
Fgfr3 [plasma membrane] (Mus musculus)
Fgfr3 [plasma membrane] (Rattus norvegicus)
FGFR3 [plasma membrane] (Bos taurus)
FGFR3 [plasma membrane] (Canis familiaris)
taf5 [plasma membrane] (Xenopus tropicalis)
Tie [plasma membrane] (Drosophila melanogaster)
htl [plasma membrane] (Drosophila melanogaster)
Cross References
RefSeq
NP_075254.1
,
NP_001156685.1
,
NP_000133.1
ZINC - World Drugs
FGFR3_HUMAN
OpenTargets
ENSG00000068078
ZINC - FDA approved
FGFR3_HUMAN
ZINC - Substances
FGFR3_HUMAN
ZINC target
P22607
ZINC - Biogenic
FGFR3_HUMAN
PRO
P22607
PDB
2LZL
,
6LVM
,
1RY7
,
4K33
,
6PNX
ZINC - Investigational
FGFR3_HUMAN
HPA
ENSG00000068078-FGFR3
GeneCards
P22607
Ensembl
ENSP00000414914
,
ENSP00000231803
,
ENST00000412135
,
ENSP00000339824
,
ENST00000440486
,
ENSG00000068078
,
ENST00000352904
,
ENST00000340107
,
ENSP00000412903
Orphanet
16047
ZINC - Predictions - Purchasable
FGFR3_HUMAN
Interactors (46)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8N3R9 MPP5
1
MPP5 [plasma membrane]
(R-HSA-419969)
0.556
3
UniProt:O15534 PER1
4
p-S-PER1 [nucleoplasm]
(R-HSA-3325590)
p-S-PER1 [cytosol]
(R-HSA-400310)
PER1 [cytosol]
(R-HSA-400373)
Ub-p-S-PER1 [cytosol]
(R-HSA-517831)
0.556
3
UniProt:O95674 CDS2
1
CDS2 [mitochondrial inner membrane]
(R-HSA-1498755)
0.556
3
UniProt:Q00994 BEX3
1
NGFRAP1 [cytosol]
(R-HSA-194333)
0.556
3
UniProt:Q99743 NPAS2
2
p-S-NPAS2 [nucleoplasm]
(R-HSA-421309)
NPAS2 [cytosol]
(R-HSA-400314)
0.556
3
UniProt:P22692 IGFBP4
5
p-IGFBP4 [endoplasmic reticulum lumen]
(R-HSA-8957038)
IGFBP4 [endoplasmic reticulum lumen]
(R-HSA-8956754)
IGFBP4 [extracellular region]
(R-HSA-381421)
IGFBP4(157-237) [extracellular region]
(R-HSA-381510)
IGFBP4(22-156) [extracellular region]
(R-HSA-381516)
0.556
3
UniProt:P22415 USF1
1
USF1 [nucleoplasm]
(R-HSA-9023562)
0.556
3
UniProt:P23771 GATA3
2
PolyUb-GATA3 [nucleoplasm]
(R-HSA-6783009)
GATA3 [nucleoplasm]
(R-HSA-996768)
0.556
3
UniProt:A0AVK6 E2F8
1
E2F8 [nucleoplasm]
(R-HSA-8952990)
0.556
3
UniProt:Q6NXG1 ESRP1
3
ESRP1-RAF1 fusion [cytosol]
(R-HSA-6802312)
p-ESRP1-RAF1 fusion [cytosol]
(R-HSA-6802523)
ESRP1 [nucleoplasm]
(R-HSA-6803472)
0.556
3
UniProt:Q04206 RELA
6
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
SUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
RELA [nucleoplasm]
(R-HSA-177676)
RELA [cytosol]
(R-HSA-168172)
0.556
3
UniProt:P55318 FOXA3
1
FOXA3 [nucleoplasm]
(R-HSA-211484)
0.556
3
UniProt:P10809 HSPD1
6
HSPD1 [mitochondrial inner membrane]
(R-HSA-1299455)
HSPD1 [mitochondrial matrix]
(R-HSA-1299448)
HSPD1(1-573) [cytosol]
(R-HSA-1267989)
HSPD1(1-573) [mitochondrial inner membrane]
(R-HSA-1299442)
HSPD1(1-26) [mitochondrial matrix]
(R-HSA-8986171)
HSPD1(1-573) [mitochondrial intermembrane space]
(R-HSA-1267963)
0.556
3
UniProt:Q13352 ITGB3BP
2
ITGB3BP [nucleoplasm]
(R-HSA-606325)
ITGB3BP [cytosol]
(R-HSA-3006405)
0.556
3
UniProt:Q9UNP9 PPIE
4
PPIE [extracellular region]
(R-HSA-6806493)
PPIE [ficolin-1-rich granule lumen]
(R-HSA-6801393)
PPIE [secretory granule lumen]
(R-HSA-6801369)
PPIE [nucleoplasm]
(R-HSA-6781959)
0.556
3
UniProt:Q86WV5 TEN1
1
TEN1 [nucleoplasm]
(R-HSA-9668823)
0.556
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.556
3
UniProt:Q96T60 PNKP
1
PNKP [nucleoplasm]
(R-HSA-5649651)
0.556
3
UniProt:P38936 CDKN1A
5
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
CDKN1A [cytosol]
(R-HSA-182512)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
CDKN1A [nucleoplasm]
(R-HSA-182585)
0.556
3
UniProt:P24941 CDK2
5
p-CDK2 [nucleoplasm]
(R-HSA-68370)
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.556
3
UniProt:Q8WUX9 CHMP7
2
CHMP7 [endosome membrane]
(R-HSA-9631168)
CHMP7 [cytosol]
(R-HSA-917703)
0.556
3
UniProt:Q9Y2Y0 ARL2BP
2
ARL2BP [mitochondrial matrix]
(R-HSA-5250220)
ARL2BP [cytosol]
(R-HSA-5215982)
0.556
3
UniProt:Q9UJU6 DBNL
7
DBNL(362-431) [cytosol]
(R-HSA-202933)
DBNL [cytosol]
(R-HSA-202880)
DBNL(1-361) [cytosol]
(R-HSA-202925)
DBNL [tertiary granule lumen]
(R-HSA-6801516)
DBNL [extracellular region]
(R-HSA-6801604)
DBNL [secretory granule lumen]
(R-HSA-6801520)
DBNL [ficolin-1-rich granule lumen]
(R-HSA-6801510)
0.556
3
UniProt:Q9NZH6 IL37
6
IL37(?-218) [extracellular region]
(R-HSA-9008607)
IL37(?-218) [nucleoplasm]
(R-HSA-9008702)
IL37 [extracellular region]
(R-HSA-8848334)
IL37(?-218) [cytosol]
(R-HSA-9008584)
IL37 [cytosol]
(R-HSA-9008596)
IL37(1-?) [cytosol]
(R-HSA-9008602)
0.556
3
UniProt:O14544 SOCS6
1
SOCS6 [cytosol]
(R-HSA-1469969)
0.556
3
UniProt:Q9BVC3 DSCC1
1
DSCC1 [nucleoplasm]
(R-HSA-9668907)
0.556
3
UniProt:Q07869 PPARA
2
PPARA [nucleoplasm]
(R-HSA-400186)
SUMO1-K185-PPARA [nucleoplasm]
(R-HSA-4341099)
0.556
3
UniProt:Q8N5V2 NGEF
2
p-Y179-NGEF [cytosol]
(R-HSA-3928441)
NGEF [cytosol]
(R-HSA-3006800)
0.556
3
UniProt:Q6IAA8 LAMTOR1
5
LAMTOR1 [ficolin-1-rich granule membrane]
(R-HSA-6801003)
LAMTOR1 [lysosomal membrane]
(R-HSA-5653582)
LAMTOR1 [plasma membrane]
(R-HSA-6806270)
LAMTOR1 [azurophil granule membrane]
(R-HSA-6799633)
LAMTOR1 [specific granule membrane]
(R-HSA-6799631)
0.556
3
UniProt:P62244 RPS15A
2
RPS15A [cytosol]
(R-HSA-72345)
RPS15A [nucleoplasm]
(R-HSA-6791191)
0.556
3
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.556
3
UniProt:Q06547-2 GABPB1
1
NRF2 beta-2 subunit [nucleoplasm]
(R-HSA-1592200)
0.556
3
UniProt:Q06547-3 GABPB1
1
NRF2 gamma-1 subunit [nucleoplasm]
(R-HSA-1592216)
0.556
3
UniProt:Q15814 TBCC
1
TBCC [cytosol]
(R-HSA-379537)
0.556
3
UniProt:Q9H2A9 CHST8
1
CHST8 [Golgi membrane]
(R-HSA-6786024)
0.556
3
UniProt:P05412 JUN
4
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [nucleoplasm]
(R-HSA-450250)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.556
3
UniProt:Q9UBX5 FBLN5
1
FBLN5 [extracellular region]
(R-HSA-2161278)
0.556
3
UniProt:Q9BXU0 TEX12
1
TEX12 [nucleoplasm]
(R-HSA-912441)
0.556
3
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [cytosol]
(R-HSA-5205651)
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
0.556
3
UniProt:Q16621 NFE2
1
NFE2 [nucleoplasm]
(R-HSA-1008221)
0.556
3
UniProt:Q99075 HBEGF
9
HBEGF(20-208) [clathrin-coated endocytic vesicle membrane]
(R-HSA-5334782)
HBEGF(63-148) [clathrin-coated endocytic vesicle membrane]
(R-HSA-9628819)
HBEGF(20-208) [endocytic vesicle membrane]
(R-HSA-5334776)
HBEGF(20-208) [plasma membrane]
(R-HSA-5334771)
HB-EGF(161-208) [plasma membrane]
(R-HSA-9624270)
HBEGF(20-62) [extracellular region]
(R-HSA-2179390)
HBEGF(149-208) [extracellular region]
(R-HSA-2179391)
HBEGF(20-208) [plasma membrane]
(R-HSA-2179406)
HBEGF(63-148) [extracellular region]
(R-HSA-1233234)
0.556
3
UniProt:P17275 JUNB
1
JUNB [nucleoplasm]
(R-HSA-2186795)
0.556
3
UniProt:P41134 ID1
1
ID1 [nucleoplasm]
(R-HSA-2534101)
0.556
3
UniProt:O14641 DVL2
5
pp-DVL2 [cytosol]
(R-HSA-3772398)
DVL2 [cytosol]
(R-HSA-201694)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.556
3
UniProt:P19388 POLR2E
2
POLR2E [cytosol]
(R-HSA-1964438)
POLR2E [nucleoplasm]
(R-HSA-83713)
0.556
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.524
2
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