p-6Y-FGFR3b G697C [plasma membrane]

Stable Identifier
R-HSA-2032969
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-6XY-FGFR3-2 G697C
Icon
p-6Y-FGFR3b G697C [plasma membrane] icon
p-6Y-FGFR3b G697C [plasma membrane] icon
Locations in the PathwayBrowser
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General

Note that residue G697C is numbered according to the FGFR3c isoform, (UniProt 22607-1) and actually corresponds to G699C in the FGFR3b isoform (Uniprot 22607-2).

Literature References
PubMed ID Title Journal Year
15880580 Constitutive activating mutation of the FGFR3b in oral squamous cell carcinomas

Sato, JD, Toratani, S, Hayashido, Y, Wang, H, Hiraishi, Y, Zhang, Y, Sumi, KS, Kan, M, Okamoto, T

Int J Cancer 2005
External Reference Information
External Reference
UniProt:P22607-2 FGFR3
Gene Names
FGFR3, JTK4
Other Identifiers
0002940050
0003850722
11717969_a_at
11755786_a_at
16964027
204379_PM_s_at
204379_s_at
204380_PM_s_at
204380_s_at
2261
2715017
2715018
2715019
2715026
2715027
2715028
2715029
2715030
2715031
2715032
2715033
2715039
2715040
2715041
2715042
2715043
2715045
2715046
2715047
2715048
2715049
2715051
2715053
2715054
2715056
2715057
2715058
31805_at
8093518
A_14_P132738
A_23_P212830
A_23_P500501
GE577766
GE58034
GO:0000165
GO:0000166
GO:0001501
GO:0001958
GO:0002062
GO:0003416
GO:0004672
GO:0004713
GO:0004714
GO:0005007
GO:0005515
GO:0005524
GO:0005576
GO:0005622
GO:0005634
GO:0005737
GO:0005783
GO:0005794
GO:0005886
GO:0005887
GO:0005925
GO:0006468
GO:0006629
GO:0006915
GO:0007169
GO:0007267
GO:0008284
GO:0008543
GO:0009986
GO:0010518
GO:0012501
GO:0016020
GO:0016021
GO:0016301
GO:0016310
GO:0016740
GO:0017134
GO:0018108
GO:0023052
GO:0030133
GO:0030154
GO:0030282
GO:0031410
GO:0032991
GO:0033674
GO:0035988
GO:0036211
GO:0042531
GO:0042802
GO:0043226
GO:0043235
GO:0043410
GO:0043552
GO:0046777
GO:0048640
GO:0048856
GO:0060089
GO:0060349
GO:0070374
GO:0070977
GO:0071495
GO:0140096
GO:1902178
HMNXSV003038877
ILMN_1651966
ILMN_1723123
M64347_at
TC04000029.hg
TC04001856.hg
g13112046_3p_a_at
g182568_3p_a_at
Participates
as a component of
Other forms of this molecule
FGFR3b G697C [plasma membrane]
FGFR3b S249C [plasma membrane]
p-6Y-FGFR3b S249C mutant [plasma membrane]
FGFR3b [plasma membrane]
p-6Y-FGFR3b [plasma membrane]
Modified Residues
Name
O4'-phospho-L-tyrosine at 579
Coordinate
579
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 649
Coordinate
649
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 650
Coordinate
650
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 726
Coordinate
726
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 762
Coordinate
762
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 772
Coordinate
772
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
glycine 697 replaced with L-cysteine
Coordinate
697
PsiMod
glycine removal [MOD:01638]
A protein modification that effectively removes or replaces an glycine.
L-cysteine residue [MOD:00014]
A protein modification that effectively converts a source amino acid residue to an L-cysteine.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
head and neck squamous cell carcinoma DOID:5520 carcinoma of the head and neck, squamous cell carcinoma of the head and neck
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
ZINC - Investigational
COSMIC
GeneCards
HPA
Ensembl
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
Interactors (46)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P08238 HSP90AB1  6 0.667 4
 UniProt:O95674 CDS2  1 0.659 4
 UniProt:Q99743 NPAS2  2 0.556 3
 UniProt:O15534 PER1  4 0.556 3
 UniProt:Q9Y2Y0 ARL2BP  2 0.556 3
 UniProt:Q04206 RELA  6 0.556 3
 UniProt:Q9NZH6 IL37  6 0.556 3
 UniProt:Q8N5V2 NGEF  2 0.556 3
 UniProt:P62333 PSMC6  2 0.556 3
 UniProt:P62244 RPS15A  2 0.556 3
 UniProt:Q9UJU6 DBNL  7 0.556 3
 UniProt:Q9BVC3 DSCC1  1 0.556 3
 UniProt:Q16621 NFE2  1 0.556 3
 UniProt:P10809 HSPD1  6 0.556 3
 UniProt:P23771 GATA3  2 0.556 3
 UniProt:A0AVK6 E2F8  1 0.556 3
 UniProt:O14544 SOCS6  1 0.556 3
 UniProt:Q07869 PPARA  2 0.556 3
 UniProt:Q06547-2 GABPB1  1 0.556 3
 UniProt:P22692 IGFBP4  5 0.556 3
 UniProt:Q6NXG1 ESRP1  3 0.556 3
 UniProt:P05412 JUN  4 0.556 3
 UniProt:Q00994 BEX3  1 0.556 3
 UniProt:P24941 CDK2  5 0.556 3
 UniProt:P01106 MYC  2 0.556 3
 UniProt:Q9BXU0 TEX12  1 0.556 3
 UniProt:Q8WUX9 CHMP7  2 0.556 3
 UniProt:Q86WV5 TEN1  1 0.556 3
 UniProt:P38936 CDKN1A  5 0.556 3
 UniProt:P17275 JUNB  1 0.556 3
 UniProt:Q9GZQ8 MAP1LC3B  3 0.556 3
 UniProt:Q15814 TBCC  1 0.556 3
 UniProt:Q8N3R9 PALS1  2 0.556 3
 UniProt:Q99075 HBEGF  8 0.556 3
 UniProt:Q9UBX5 FBLN5  1 0.556 3
 UniProt:P41134 ID1  1 0.556 3
 UniProt:Q06547-3 GABPB1  1 0.556 3
 UniProt:P55318 FOXA3  1 0.556 3
 UniProt:P22415 USF1  1 0.556 3
 UniProt:Q13352 ITGB3BP  2 0.556 3
 UniProt:Q96T60 PNKP  1 0.556 3
 UniProt:Q13573 SNW1  1 0.556 3
 UniProt:P19388 POLR2E  2 0.556 3
 UniProt:O14641 DVL2  5 0.556 3
 UniProt:Q6IAA8 LAMTOR1  5 0.556 3
 UniProt:Q9H2A9 CHST8  1 0.556 3
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