p-6Y-FGFR3b G697C [plasma membrane]

Stable Identifier
R-HSA-2032969
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-6XY-FGFR3-2 G697C
Icon
p-6Y-FGFR3b G697C [plasma membrane] icon
p-6Y-FGFR3b G697C [plasma membrane] icon
Locations in the PathwayBrowser
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General

Note that residue G697C is numbered according to the FGFR3c isoform, (UniProt 22607-1) and actually corresponds to G699C in the FGFR3b isoform (Uniprot 22607-2).

Literature References
PubMed ID Title Journal Year
15880580 Constitutive activating mutation of the FGFR3b in oral squamous cell carcinomas

Zhang, Y, Hiraishi, Y, Wang, H, Sumi, KS, Hayashido, Y, Toratani, S, Kan, M, Sato, JD, Okamoto, T

Int J Cancer 2005
External Reference Information
External Reference
UniProt:P22607-2 FGFR3
Gene Names
FGFR3, JTK4
Other Identifiers
0002940050
0003850722
11717969_a_at
11755786_a_at
16964027
1RY7
204379_s_at
204380_s_at
2261
2715017
2715018
2715019
2715026
2715027
2715028
2715029
2715030
2715031
2715032
2715033
2715039
2715040
2715041
2715042
2715043
2715045
2715046
2715047
2715048
2715049
2715051
2715053
2715054
2715056
2715057
2715058
2LZL
31805_at
4231
4K33
67204
8093518
A_14_P132738
A_23_P212830
A_23_P500501
AAA52450
AAA58470
AAA63209
AAA67781
AAB33323
AAF63380
AAU89726
AB209441
AC016773
AF245114
AY768549
BAD92678
CAA59334
CAB004231
CCDS3353
CCDS3354
CCDS54706
CH471131
EAW82564
EAW82565
EAW82566
EAW82567
ENSG00000068078
ENSP00000231803
ENSP00000339824
ENSP00000412903
ENSP00000414914
ENSP00000479472
ENST00000340107
ENST00000340107.8
ENST00000352904
ENST00000352904.6
ENST00000412135
ENST00000412135.6
ENST00000440486
ENST00000440486.7
ENST00000613647
EntrezGene:2261
EntrezGene:FGFR3
F8W9L4
FGFR3
FGFR3-202
FGFR3-203
FGFR3-204
FGFR3-205
g13112046_3p_a_at
g182568_3p_a_at
GE577766
GE58034
GO:0000165
GO:0000166
GO:0001501
GO:0001958
GO:0002062
GO:0003416
GO:0003674
GO:0004672
GO:0004713
GO:0004714
GO:0005007
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005783
GO:0005794
GO:0005886
GO:0005887
GO:0005925
GO:0006464
GO:0006468
GO:0006629
GO:0006915
GO:0007165
GO:0007169
GO:0007267
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008543
GO:0009986
GO:0010518
GO:0016020
GO:0016021
GO:0016301
GO:0016310
GO:0016740
GO:0017134
GO:0018108
GO:0021700
GO:0030133
GO:0030154
GO:0030282
GO:0031410
GO:0032991
GO:0035988
GO:0040007
GO:0042531
GO:0042802
GO:0043167
GO:0043226
GO:0043235
GO:0043410
GO:0043552
GO:0046777
GO:0048640
GO:0048856
GO:0051897
GO:0060349
GO:0070374
GO:0070977
GO:1902178
HGNC:3690
HPA067204
I6LM06
ILMN_1651966
ILMN_1723123
IPR000719
IPR001245
IPR003598
IPR003599
IPR007110
IPR008266
IPR011009
IPR013098
IPR013783
IPR016248
IPR017441
IPR020635
IPR036179
IPR041159
LRG_1021
LRG_1021t1
LRG_1021t2
M58051
M59374
M64347
M64347_at
MIM:100800
MIM:109800
MIM:114500
MIM:134934
MIM:146000
MIM:149730
MIM:162900
MIM:187600
MIM:187601
MIM:273300
MIM:602849
MIM:603956
MIM:610474
MIM:612247
MIM:616482
NM_000142
NM_001163213
NM_001354809
NM_022965
NP_000133
NP_001156685
NP_001341738
NP_075254
PF07679
PF07714
PF13927
PF18123
PR00109
Q96T34
S76733
SM00219
SM00408
SM00409
TC04000029.hg
TC04001856.hg
U22410
UPI000002A9AC
UPI000002A9AD
UPI000012A72C
X84939
XM_006713868
XM_006713869
XM_006713870
XM_006713871
XM_006713873
XM_011513420
XM_011513422
XP_006713931
XP_006713932
XP_006713933
XP_006713934
XP_006713936
XP_011511722
XP_011511724
Participant Of
hasComponent
Other forms of this molecule
FGFR3b G697C [plasma membrane]
FGFR3b S249C [plasma membrane]
p-6Y-FGFR3b S249C mutant [plasma membrane]
FGFR3b [plasma membrane]
p-6Y-FGFR3b [plasma membrane]
Modified Residues
Name
O4'-phospho-L-tyrosine at 579
Coordinate
579
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 649
Coordinate
649
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 650
Coordinate
650
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 726
Coordinate
726
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 762
Coordinate
762
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 772
Coordinate
772
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
glycine 697 replaced with L-cysteine
Coordinate
697
PsiMod
L-cysteine residue [MOD:00014]
A protein modification that effectively converts a source amino acid residue to an L-cysteine.
glycine removal [MOD:01638]
A protein modification that effectively removes or replaces an glycine.
Disease
Name Identifier Synonyms
head and neck squamous cell carcinoma 5520 carcinoma of the head and neck, squamous cell carcinoma of the head and neck
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Investigational
COSMIC
GeneCards
ZINC - Predictions - Purchasable
Orphanet
Interactors (1)