Reactome | p-6Y-FGFR3b S249C mutant [plasma membrane]

p-6Y-FGFR3b S249C mutant [plasma membrane]

Stable Identifier

R-HSA-1226874

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p-6Y-FGFR3-2 S249C mutant

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by FGFR in disease (Homo sapiens)
    - Signaling by FGFR3 in disease (Homo sapiens)
      - Activated FGFR3 point and translocation mutants bind PLCG1 (Homo sapiens)
        
        Activated FGFR3 point and translocation mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 cysteine mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        p-6Y-FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point and translocation mutants: PLCG1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point and translocation mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 cysteine mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        p-6Y-FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
      - Activated FGFR3 point and translocation mutants phosphorylate PLCG1 (Homo sapiens)
        
        Activated FGFR3 point and translocation mutants: PLCG1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point and translocation mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 cysteine mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        p-6Y-FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point and translocation mutants:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point and translocation mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 cysteine mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        p-6Y-FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
      - Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 cysteine mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        p-6Y-FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
      - Activated FGFR3 point, translocation and fusion mutants bind FRS2 (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 cysteine mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        p-6Y-FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants:FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 cysteine mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        p-6Y-FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
      - Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2 (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants:FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 cysteine mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        p-6Y-FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 cysteine mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        p-6Y-FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
      - Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 cysteine mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        p-6Y-FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 cysteine mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        p-6Y-FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
      - Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 cysteine mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        p-6Y-FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 cysteine mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        p-6Y-FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
      - Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 cysteine mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        p-6Y-FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 cysteine mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        p-6Y-FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
      - Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
        
        FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point, translocation and fusion mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 cysteine mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        p-6Y-FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
      - FGFR3 mutant receptor activation (Homo sapiens)
        
        Signaling by activated point mutants of FGFR3 (Homo sapiens)
        
        Autocatalytic phosphorylation of FGFR3 cysteine mutants (Homo sapiens)
        
        Activated FGFR3 cysteine mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        p-6Y-FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
      - p-4Y-PLCG1 dissociates from activated FGFR3 point and translocation mutants (Homo sapiens)
        
        Activated FGFR3 point and translocation mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 cysteine mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        p-6Y-FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point and translocation mutants:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 point and translocation mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3 cysteine mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR3b S249C mutant [plasma membrane] (Homo sapiens)
        
        p-6Y-FGFR3b S249C mutant [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P22607-2 FGFR3

Gene Names

FGFR3, JTK4

Other Identifiers

11717969_a_at

11755786_a_at

16964027

204379_PM_s_at

204379_s_at

204380_PM_s_at

204380_s_at

2261

2715017

2715018

2715019

2715026

2715027

2715028

2715029

2715030

2715031

2715032

2715033

2715034

2715035

2715036

2715037

2715038

2715039

2715040

2715041

2715042

2715043

2715044

2715045

2715046

2715047

2715048

2715049

2715050

2715051

2715052

2715053

2715054

2715055

2715056

2715057

2715058

31805_at

8093518

A_14_P128357

A_14_P132738

A_23_P212830

A_23_P500501

GE577766

GE58034

GO:0000165

GO:0001501

GO:0001958

GO:0002062

GO:0003416

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005007

GO:0005515

GO:0005524

GO:0005576

GO:0005783

GO:0005794

GO:0005886

GO:0005925

GO:0006468

GO:0006915

GO:0007259

GO:0007267

GO:0008284

GO:0008543

GO:0009986

GO:0010518

GO:0012501

GO:0016020

GO:0016740

GO:0017134

GO:0023052

GO:0030133

GO:0030154

GO:0030282

GO:0031410

GO:0035988

GO:0042531

GO:0042802

GO:0043226

GO:0043235

GO:0043410

GO:0048640

GO:0048856

GO:0051897

GO:0060089

GO:0060349

GO:0070374

GO:0070977

GO:0140096

GO:1902178

HMNXSV003038877

ILMN_1651966

ILMN_1723123

M64347_at

TC04000029.hg

TC04001856.hg

g13112046_3p_a_at

g182568_3p_a_at

Participates

as a component of

Activated FGFR3b S249C mutant [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-6Y-FGFR3b [plasma membrane]

FGFR3b [plasma membrane]

p-6Y-FGFR3b G697C [plasma membrane]

FGFR3b S249C [plasma membrane]

FGFR3b G697C [plasma membrane]

Modified Residues

Name

O4'-phospho-L-tyrosine at 579

Coordinate

579

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 649

Coordinate

649

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 650

Coordinate

650

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 726

Coordinate

726

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 762

Coordinate

762

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 772

Coordinate

772

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

L-serine 249 replaced with L-cysteine

Coordinate

249

PsiMod

L-serine removal [MOD:01646]

A protein modification that effectively removes or replaces an L-serine.

L-cysteine residue [MOD:00014]

A protein modification that effectively converts a source amino acid residue to an L-cysteine.

Disease

Name	Identifier	Synonyms
bladder carcinoma	DOID:4007	carcinoma of urinary bladder, carcinoma bladder, carcinoma OF BLADDER, carcinoma of bladder (disorder), carcinoma bladder
cervical cancer	DOID:4362	neoplasm of uterine cervix (disorder), tumor of the Cervix Uteri, cervix uteri cancer, cervical neoplasm, cervix cancer
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
head and neck squamous cell carcinoma	DOID:5520	carcinoma of the head and neck, squamous cell carcinoma of the head and neck
bone development disease	DOID:0080006
prostate cancer	DOID:10283	NGP - New growth of prostate, neoplasm of prostate (disorder), tumor of the prostate, malignant tumor of prostate (disorder), prostate neoplasm, malignant tumor of the prostate, malignant tumor of prostate (disorder), prostatic cancer, prostatic neoplasm
thanatophoric dysplasia	DOID:13481

Cross References

RefSeq

NP_000133.1, NP_075254.1, NP_001156685.1

Guide to Pharmacology - Targets

1810

OpenTargets

ENSG00000068078

ENSEMBL

ENSP00000339824, ENST00000440486, ENSP00000231803, ENST00000340107, ENST00000352904, ENSG00000068078, ENSP00000414914

ZINC - FDA approved

FGFR3_HUMAN

ZINC - Substances

FGFR3_HUMAN

ZINC - Biogenic

FGFR3_HUMAN

ZINC target

P22607

PRO

P22607

GlyGen

P22607

PDB

7DHL, 7YSU, 2LZL, 1RY7, 4K33, 8UDU, 8UDT, 9CD7, 8UDV, 6LVM, 6PNX

ZINC - Investigational

FGFR3_HUMAN

COSMIC

COSV53390026, COSM29427

HPA

ENSG00000068078-FGFR3

GeneCards

FGFR3

Pharos - Targets

P22607

Orphanet

FGFR3

ZINC - Predictions - Purchasable

FGFR3_HUMAN

HMDB Protein

HMDBP01362

Interactors (53)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.667	4
UniProt:O95674 CDS2	1	CDS2 [mitochondrial inner membrane] (R-HSA-1498755)	0.659	4
UniProt:Q13352 ITGB3BP	2	ITGB3BP [cytosol] (R-HSA-3006405) ITGB3BP [nucleoplasm] (R-HSA-606325)	0.556	3
UniProt:Q9BXU0 TEX12	1	TEX12 [nucleoplasm] (R-HSA-912441)	0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:O15534 PER1	4	PER1 [cytosol] (R-HSA-400373) p-S-PER1 [nucleoplasm] (R-HSA-3325590) p-S-PER1 [cytosol] (R-HSA-400310) K48polyUb-K,p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:Q8N5V2 NGEF	2	p-Y179-NGEF [cytosol] (R-HSA-3928441) NGEF [cytosol] (R-HSA-3006800)	0.556	3
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) AGO2 [nucleoplasm] (R-HSA-5578701)	0.556	3
UniProt:Q9UJU6 DBNL	7	DBNL [cytosol] (R-HSA-202880) DBNL(362-431) [cytosol] (R-HSA-202933) DBNL(1-361) [cytosol] (R-HSA-202925) DBNL [ficolin-1-rich granule lumen] (R-HSA-6801510) DBNL [extracellular region] (R-HSA-6801604) DBNL [tertiary granule lumen] (R-HSA-6801516) DBNL [secretory granule lumen] (R-HSA-6801520)	0.556	3
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [cytosol] (R-HSA-5205651) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [autophagosome membrane] (R-HSA-5683641)	0.556	3
UniProt:Q9NZH6 IL37	6	IL37(?-218) [extracellular region] (R-HSA-9008607) IL37 [extracellular region] (R-HSA-8848334) IL37(?-218) [cytosol] (R-HSA-9008584) IL37 [cytosol] (R-HSA-9008596) IL37(1-?) [cytosol] (R-HSA-9008602) IL37(?-218) [nucleoplasm] (R-HSA-9008702)	0.556	3
UniProt:P38936 CDKN1A	5	CDKN1A [nucleoplasm] (R-HSA-182585) CDKN1A [cytosol] (R-HSA-182512) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) p-T145-CDKN1A [cytosol] (R-HSA-198614)	0.556	3
UniProt:O14544 SOCS6	1	SOCS6 [cytosol] (R-HSA-1469969)	0.556	3
UniProt:P55318 FOXA3	1	FOXA3 [nucleoplasm] (R-HSA-211484)	0.556	3
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.556	3
UniProt:Q7Z7J5 DPPA2	1	DPPA2 [nucleoplasm] (R-HSA-9816401)	0.556	3
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.556	3
UniProt:Q9BVC3 DSCC1	1	DSCC1 [nucleoplasm] (R-HSA-9668907)	0.556	3
UniProt:P10809 HSPD1	6	HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.556	3
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.556	3
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.556	3
UniProt:P17275 JUNB	1	JUNB [nucleoplasm] (R-HSA-2186795)	0.556	3
UniProt:P22415 USF1	2	USF1 [nucleoplasm] (R-HSA-9023562) pT153 USF1 [nucleoplasm] (R-HSA-9855887)	0.556	3
UniProt:P62244 RPS15A	2	RPS15A [cytosol] (R-HSA-72345) RPS15A [nucleoplasm] (R-HSA-6791191)	0.556	3
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.556	3
UniProt:Q8WUX9 CHMP7	2	CHMP7 [cytosol] (R-HSA-917703) CHMP7 [endosome membrane] (R-HSA-9631168)	0.556	3
UniProt:O43504 LAMTOR5	1	LAMTOR5 [lysosomal membrane] (R-HSA-5655441)	0.556	3
UniProt:Q99743 NPAS2	2	NPAS2 [cytosol] (R-HSA-400314) p-NPAS2 [nucleoplasm] (R-HSA-421309)	0.556	3
UniProt:Q86WV5 TEN1	1	TEN1 [nucleoplasm] (R-HSA-9668823)	0.556	3
UniProt:Q8N3R9 MPP5	2	MPP5 [plasma membrane] (R-HSA-419969) MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9689606)	0.556	3
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.556	3
UniProt:P22692 IGFBP4	5	IGFBP4 [extracellular region] (R-HSA-381421) IGFBP4(157-237) [extracellular region] (R-HSA-381510) IGFBP4(22-156) [extracellular region] (R-HSA-381516) IGFBP4 [endoplasmic reticulum lumen] (R-HSA-8956754) p-IGFBP4 [endoplasmic reticulum lumen] (R-HSA-8957038)	0.556	3
UniProt:Q00994 BEX3	1	NGFRAP1 [cytosol] (R-HSA-194333)	0.556	3
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.556	3
UniProt:Q6N021 TET2	1	TET2 [nucleoplasm] (R-HSA-5221011)	0.556	3
UniProt:Q15814 TBCC	1	TBCC [cytosol] (R-HSA-379537)	0.556	3
UniProt:Q99075 HBEGF	8	HBEGF(63-148) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628819) HBEGF(20-208) [clathrin-coated endocytic vesicle membrane] (R-HSA-5334782) HBEGF(20-208) [endocytic vesicle membrane] (R-HSA-5334776) HB-EGF(161-208) [plasma membrane] (R-HSA-9624270) HBEGF(20-62) [extracellular region] (R-HSA-2179390) HBEGF(149-208) [extracellular region] (R-HSA-2179391) HBEGF(20-208) [plasma membrane] (R-HSA-2179406) HBEGF(63-148) [extracellular region] (R-HSA-1233234)	0.556	3
UniProt:Q6NXG1 ESRP1	3	ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol] (R-HSA-6802523) ESRP1(1-606)-RAF1(227-648) fusion [cytosol] (R-HSA-6802312) ESRP1 [nucleoplasm] (R-HSA-6803472)	0.556	3
UniProt:Q6IAA8 LAMTOR1	5	LAMTOR1 [lysosomal membrane] (R-HSA-5653582) LAMTOR1 [specific granule membrane] (R-HSA-6799631) LAMTOR1 [plasma membrane] (R-HSA-6806270) LAMTOR1 [azurophil granule membrane] (R-HSA-6799633) LAMTOR1 [ficolin-1-rich granule membrane] (R-HSA-6801003)	0.556	3
UniProt:Q9UBX5 FBLN5	1	FBLN5 [extracellular region] (R-HSA-2161278)	0.556	3
UniProt:Q07869 PPARA	2	PPARA [nucleoplasm] (R-HSA-400186) monoSUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099)	0.556	3
UniProt:Q9Y2Y0 ARL2BP	2	ARL2BP [cytosol] (R-HSA-5215982) ARL2BP [mitochondrial matrix] (R-HSA-5250220)	0.556	3
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.556	3
UniProt:P41134 ID1	1	ID1 [nucleoplasm] (R-HSA-2534101)	0.556	3
UniProt:A0AVK6 E2F8	1	E2F8 [nucleoplasm] (R-HSA-8952990)	0.556	3
UniProt:Q06323 PSME1	1	PSME1 [cytosol] (R-HSA-68812)	0.556	3
UniProt:P24941 CDK2	5	p-T160-CDK2 [nucleoplasm] (R-HSA-187967) CDK2 [nucleoplasm] (R-HSA-68365) CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905)	0.556	3
UniProt:Q06547-2 GABPB1	1	NRF2 beta-2 subunit [nucleoplasm] (R-HSA-1592200)	0.556	3
UniProt:Q9H2A9 CHST8	1	CHST8 [Golgi membrane] (R-HSA-6786024)	0.556	3
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.556	3
UniProt:Q06547-3 GABPB1	1	NRF2 gamma-1 subunit [nucleoplasm] (R-HSA-1592216)	0.556	3
UniProt:Q16621 NFE2	1	NFE2 [nucleoplasm] (R-HSA-1008221)	0.556	3
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3