Reactome | ATP6V0C [tertiary granule membrane]

ATP6V0C [tertiary granule membrane]

Stable Identifier

R-HSA-6800991

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

tertiary granule membrane

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P27449 ATP6V0C

Gene Names

ATP6V0C, ATP6C, ATP6L, ATPL

Chain

chain:1-155

Reference Genes

BioGPS Gene:527 ATP6V0C

COSMIC (genes):ATP6V0C ATP6V0C

CTD Gene:527 ATP6V0C

dbSNP Gene:527 ATP6V0C

ENSEMBL:ENSG00000185883 ATP6V0C

ENSEMBL_homo_sapiens_GENE:ENSG00000185883.12 ATP6V0C

HGNC:855 ATP6V0C

KEGG Gene (Homo sapiens):527 ATP6V0C

Monarch:527 ATP6V0C

NCBI Gene:527 ATP6V0C

OMIM:108745 ATP6V0C

UCSC:P27449 ATP6V0C

Reference Transcript

Other Identifiers

11715787_x_at

16815137

3644913

3644914

3644915

3644920

3644921

3644922

3644923

3644933

3644934

36994_3p_at

36994_PM_at

36994_at

4901150C_3p_at

4901150C_3p_x_at

527

75090_at

7992646

A_23_P54816

A_24_P279220

GE525173

GE61197

GO:0000139

GO:0000220

GO:0003824

GO:0005215

GO:0005515

GO:0005576

GO:0005615

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005794

GO:0005886

GO:0005925

GO:0006811

GO:0006914

GO:0007035

GO:0007040

GO:0007042

GO:0010008

GO:0015078

GO:0015986

GO:0016020

GO:0016241

GO:0016874

GO:0023052

GO:0030177

GO:0030665

GO:0030670

GO:0030672

GO:0031410

GO:0031625

GO:0033176

GO:0033177

GO:0033179

GO:0035577

GO:0043226

GO:0045202

GO:0046933

GO:0046961

GO:0048388

GO:0051452

GO:0055085

GO:0055086

GO:0061795

GO:0070062

GO:0070821

GO:0101003

GO:0140657

GO:1901135

GO:1902495

GO:1902600

HMNXSV003032225

ILMN_1773849

ILMN_1789005

TC16002054.hg

g4502312_3p_s_at

Participates

as a member of

Tertiary granule membrane proteins [tertiary granule membrane] (Homo sapiens)

Other forms of this molecule

ATP6V0C [endosome membrane]

ATP6V0C [plasma membrane]

ATP6V0C [ficolin-1-rich granule membrane]

ATP6V0C [azurophil granule membrane]

ATP6V0C [phagocytic vesicle membrane]

ATP6V0C [lysosomal membrane]

Inferred To

ATP6V0C [tertiary granule membrane] (Bos taurus)

ATP6V0C [tertiary granule membrane] (Canis familiaris)

ATP6V0C [tertiary granule membrane] (Gallus gallus)

ATP6V0C [tertiary granule membrane] (Plasmodium falciparum)

ATP6V0C [tertiary granule membrane] (Sus scrofa)

Vha16-1 [tertiary granule membrane] (Drosophila melanogaster)

vma3 [tertiary granule membrane] (Schizosaccharomyces pombe)

vha-3 [tertiary granule membrane] (Caenorhabditis elegans)

atp6v0c [tertiary granule membrane] (Xenopus tropicalis)

vha-2 [tertiary granule membrane] (Caenorhabditis elegans)

VMA3 [tertiary granule membrane] (Saccharomyces cerevisiae)

Homologues of ATP6V0C [tertiary granule membrane] (Bos taurus)

Homologues of ATP6V0C [tertiary granule membrane] (Caenorhabditis elegans)

atp6v0cb [tertiary granule membrane] (Danio rerio)

vatP [tertiary granule membrane] (Dictyostelium discoideum)

Atp6v0c [tertiary granule membrane] (Mus musculus)

Atp6v0c [tertiary granule membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001185498.1, NP_001685.1

Guide to Pharmacology - Targets

828

OpenTargets

ENSG00000185883

GeneCards

P27449

HPA

ENSG00000185883-ATP6V0C

Ensembl

ENSG00000185883, ENST00000330398, ENSP00000329757

PRO

P27449

Pharos - Targets

P27449

HMDB Protein

HMDBP01481

PDB

6WLW, 7U4T, 6WM4, 7UNF, 6WM2, 6WM3

Interactors (60)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96G23 CERS2	1	CERS2 [endoplasmic reticulum membrane] (R-HSA-428171)	0.73	4
UniProt:Q9BZL3 SMIM3			0.718	6
UniProt:P21757 MSR1	2	6xHC-MSR1 [endocytic vesicle membrane] (R-HSA-2507846) 6xHC-MSR1 [plasma membrane] (R-HSA-2173717)	0.718	6
UniProt:Q86VR2 RETR3			0.666	4
UniProt:Q92838 EDA	1	EDA [plasma membrane] (R-HSA-5667156)	0.666	4
UniProt:O75787 ATP6AP2	3	ATP6AP2 [plasma membrane] (R-HSA-2022356) ATP6AP2 [tertiary granule membrane] (R-HSA-6799717) ATP6AP2 [ficolin-1-rich granule membrane] (R-HSA-6800921)	0.643	5
UniProt:P11912 CD79A	2	p-Y188,Y199-CD79A [plasma membrane] (R-HSA-983539) CD79A [plasma membrane] (R-HSA-197154)	0.556	3
UniProt:Q96KR6 F210B			0.556	3
UniProt:Q7Z5P4 HSD17B13	1	HSD17B13 [cytosol] (R-HSA-8862029)	0.556	3
UniProt:Q6UXB8 PI16			0.556	3
UniProt:Q8IV31 TM139			0.556	3
UniProt:Q6ZS10 CL17A			0.556	3
UniProt:Q9H7M9 VISTA			0.556	3
UniProt:Q8TDT2 GP152			0.556	3
UniProt:Q9P0T7 TMEM9			0.556	3
UniProt:Q13651 IL10RA	3	p-Y446-IL10RA [plasma membrane] (R-HSA-6784810) p-Y496-IL10RA [plasma membrane] (R-HSA-6784793) IL10RA [plasma membrane] (R-HSA-449841)	0.556	3
UniProt:P07307-3 ASGR2			0.556	3
UniProt:Q6P499 NIPAL3	1	NIPAL3 [plasma membrane] (R-HSA-5215974)	0.556	3
UniProt:Q96L08 SUSD3			0.556	3
UniProt:Q8N386 LRC25			0.556	3
UniProt:Q9NY72 SCN3B	1	SCN3B [plasma membrane] (R-HSA-197921)	0.556	3
UniProt:Q07108 CD69			0.556	3
UniProt:Q9H6H4 REEP4			0.556	3
UniProt:P25788 PSMA3	2	PSMA3 [nucleoplasm] (R-HSA-174323) PSMA3 [cytosol] (R-HSA-68728)	0.556	3
UniProt:P19397 CD53	3	CD53 [specific granule membrane] (R-HSA-6804793) CD53 [plasma membrane] (R-HSA-6804817) CD53 [tertiary granule membrane] (R-HSA-6804799)	0.556	3
UniProt:Q86T13 CLC14			0.556	3
UniProt:Q9HAV5 EDA2R	1	EDA2R [plasma membrane] (R-HSA-5669018)	0.556	3
UniProt:P22794 EVI2A			0.556	3
UniProt:Q96KC8 DNJC1			0.556	3
UniProt:O00155 GPR25	1	GPR25 [plasma membrane] (R-HSA-6805220)	0.556	3
IntAct:EBI-22326698 CCSB ORF ID			0.556	3
UniProt:Q8TBE3 FNDC9			0.556	3
UniProt:Q8WWF3 SSMM1			0.556	3
UniProt:Q6PEW1 ZCH12			0.556	3
UniProt:P35372-10 OPRM1			0.556	3
UniProt:O15529 GPR42			0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:Q9BQ51 PDCD1LG2	1	PDCD1LG2 [plasma membrane] (R-HSA-3211774)	0.556	3
UniProt:Q8IX19 MCEMP1	3	MCEMP1 [specific granule membrane] (R-HSA-6799637) MCEMP1 [plasma membrane] (R-HSA-6806288) MCEMP1 [tertiary granule membrane] (R-HSA-6800975)	0.556	5
UniProt:Q7Z769 S35E3			0.556	3
UniProt:Q7Z7G2 CPLX4			0.556	3
UniProt:P27105 STOM	4	STOM [tertiary granule membrane] (R-HSA-6800960) STOM [plasma membrane] (R-HSA-6806258) STOM [azurophil granule membrane] (R-HSA-6800997) STOM [specific granule membrane] (R-HSA-6799569)	0.556	3
UniProt:O15552 FFAR2	1	FFAR2 [plasma membrane] (R-HSA-443944)	0.556	3
UniProt:Q9HBV2 SACA1			0.556	3
UniProt:P84090 ERH			0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:Q92876 KLK6			0.556	3
UniProt:Q9UHP7-3 CLEC2D			0.556	3
UniProt:P26715 KLRC1	1	KLRC1 [plasma membrane] (R-HSA-3006545)	0.556	3
UniProt:Q9NR28 DIABLO	2	DIABLO [mitochondrial intermembrane space] (R-HSA-64637) DIABLO [cytosol] (R-HSA-114298)	0.556	3
UniProt:P16871 IL7R	3	p-Y449-IL7R [plasma membrane] (R-HSA-1295531) IL7R [plasma membrane] (R-HSA-449945) IL7R [clathrin-coated endocytic vesicle membrane] (R-HSA-9028500)	0.556	3
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.556	3
UniProt:Q93050 ATP6V0A1	5	ATP6V0A1 [phagocytic vesicle membrane] (R-HSA-1222308) ATP6V0A1 [ficolin-1-rich granule membrane] (R-HSA-6801296) ATP6V0A1 [plasma membrane] (R-HSA-6806520) ATP6V0A1 [secretory granule membrane] (R-HSA-6801281) ATP6V0A1 [endosome membrane] (R-HSA-912596)	0.527	3
UniProt:Q96D05 F241B			0.527	3
UniProt:Q9Y487 ATP6V0A2	2	ATP6V0A2 [phagocytic vesicle membrane] (R-HSA-1222546) ATP6V0A2 [endosome membrane] (R-HSA-912595)	0.527	3
UniProt:Q8N511 TM199			0.527	3
UniProt:Q15904 ATP6AP1	2	ATP6AP1 [endosome membrane] (R-HSA-5215981) ATP6AP1 [endoplasmic reticulum membrane] (R-HSA-9714332)	0.527	2
UniProt:Q3ZAQ7 VMA21			0.527	3
UniProt:P06576 ATP5F1B	6	ATP5B(1-47) [mitochondrial matrix] (R-HSA-8986172) ATP5B(1-529) [cytosol] (R-HSA-1267973) ATP5B(1-529) [mitochondrial intermembrane space] (R-HSA-1267985) ATP5B(1-529) [mitochondrial inner membrane] (R-HSA-1299440) ATP5B [mitochondrial inner membrane] (R-HSA-1299441) ATP5F1B [mitochondrial matrix] (R-HSA-164576)	0.527	3
UniProt:P61421 ATPV0D1	3	ATP6V0D1 [endosome membrane] (R-HSA-912592) ATP6V0D1 [phagocytic vesicle membrane] (R-HSA-1222571) ATP6V0D1 [lysosomal membrane] (R-HSA-9640177)	0.527	2

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