Reactome | NPBWR2 [plasma membrane]

NPBWR2 [plasma membrane]

Stable Identifier

R-HSA-374797

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Neuropeptides B/W receptor type 2, NPBW2_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptors [plasma membrane] (Homo sapiens)
        
        NPBWR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptors [plasma membrane] (Homo sapiens)
        
        NPBWR2 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptors [plasma membrane] (Homo sapiens)
        
        NPBWR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptors [plasma membrane] (Homo sapiens)
        
        NPBWR2 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptors [plasma membrane] (Homo sapiens)
        
        NPBWR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptors [plasma membrane] (Homo sapiens)
        
        NPBWR2 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        GPCR neuropeptide receptor binds neuropeptides B and W (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptors [plasma membrane] (Homo sapiens)
        
        NPBWR2 [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptors [plasma membrane] (Homo sapiens)
        
        NPBWR2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48146 NPBWR2

Gene Names

NPBWR2, GPR8

Chain

chain:1-333

Reference Genes

BioGPS Gene:2832 NPBWR2

COSMIC (genes):NPBWR2 NPBWR2

CTD Gene:2832 NPBWR2

dbSNP Gene:2832 NPBWR2

ENSEMBL:ENSG00000125522 NPBWR2

HGNC:4530 NPBWR2

KEGG:hsa:2832 NPBWR2

Monarch:2832 NPBWR2

NCBI Gene:2832 NPBWR2

OMIM:600731 NPBWR2

UCSC:P48146 NPBWR2

Reference Transcript

RefSeq:NM_005286.2 NPBWR2

Other Identifiers

11734590_at

16921447

221358_PM_at

221358_at

2832

3914347

3914348

3914349

3914350

8067818

ADDON002463.hg

A_23_P40334

A_33_P3269791

GE80676

GO:0004930

GO:0004985

GO:0005515

GO:0005886

GO:0007186

GO:0007218

GO:0008188

GO:0016020

GO:0038003

GO:0042923

GO:0043005

GO:0060089

HMNXSV003022132

ILMN_1769358

PH_hs_0013150

TC20001048.hg

g4885344_3p_at

Participates

as a member of

Neuropeptides B/W receptors [plasma membrane] (Homo sapiens)

Inferred To

NPBWR2 [plasma membrane] (Bos taurus)

NPBWR2 [plasma membrane] (Gallus gallus)

NPBWR2 [plasma membrane] (Sus scrofa)

npbwr1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_005277.2

Guide to Pharmacology - Targets

304

ENSEMBL

ENSP00000358783, ENSG00000277339, ENST00000612646, ENST00000369768, ENSP00000508236, ENST00000684052, ENSG00000125522, ENSP00000484253

OpenTargets

ENSG00000125522

GeneCards

NPBWR2

HPA

ENSG00000125522-NPBWR2

PRO

P48146

Pharos - Targets

P48146

GlyGen

P48146

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3