Reactome | CCL28 [extracellular region]

CCL28 [extracellular region]

Stable Identifier

R-HSA-373300

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

C-C motif chemokine 28, CCL28_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCR10:CCL27,28 [plasma membrane] (Homo sapiens)
        
        CCL27,28 [extracellular region] (Homo sapiens)
        
        CCL28 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCR10:CCL27,28 [plasma membrane] (Homo sapiens)
        
        CCL27,28 [extracellular region] (Homo sapiens)
        
        CCL28 [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCR10:CCL27,28 [plasma membrane] (Homo sapiens)
        
        CCL27,28 [extracellular region] (Homo sapiens)
        
        CCL28 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCR10:CCL27,28 [plasma membrane] (Homo sapiens)
        
        CCL27,28 [extracellular region] (Homo sapiens)
        
        CCL28 [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCR10:CCL27,28 [plasma membrane] (Homo sapiens)
        
        CCL27,28 [extracellular region] (Homo sapiens)
        
        CCL28 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCR10:CCL27,28 [plasma membrane] (Homo sapiens)
        
        CCL27,28 [extracellular region] (Homo sapiens)
        
        CCL28 [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptor CCR10 binds CCL27 and 28 ligands (Homo sapiens)
        
        CCL27,28 [extracellular region] (Homo sapiens)
        
        CCL28 [extracellular region] (Homo sapiens)
        
        CCR10:CCL27,28 [plasma membrane] (Homo sapiens)
        
        CCL27,28 [extracellular region] (Homo sapiens)
        
        CCL28 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NRJ3 CCL28

Gene Names

CCL28, SCYA28

Chain

signal peptide:1-19, chain:20-127

Reference Genes

BioGPS Gene:56477 CCL28

COSMIC (genes):CCL28 CCL28

CTD Gene:56477 CCL28

dbSNP Gene:56477 CCL28

ENSEMBL:ENSG00000151882 CCL28

HGNC:17700 CCL28

KEGG:hsa:56477 CCL28

Monarch:56477 CCL28

NCBI Gene:56477 CCL28

OMIM:605240 CCL28

UCSC:Q9NRJ3 CCL28

Reference Transcript

Other Identifiers

11745454_a_at

11759368_x_at

16995914

224027_PM_at

224027_at

224240_PM_s_at

224240_s_at

238750_PM_at

238750_at

2855543

2855544

2855545

2855546

2855547

2855548

2855549

2855550

2855551

2855557

2855558

2855559

2855563

2855564

2855565

2855570

2855571

44210_at

52449_at

56477

8111932

A_23_P503072

GE812258

GO:0001954

GO:0002376

GO:0005125

GO:0005515

GO:0005576

GO:0005615

GO:0006935

GO:0006955

GO:0007165

GO:0007204

GO:0007584

GO:0008009

GO:0043226

GO:0048018

GO:0048870

GO:0060326

GO:0070062

GO:0098772

GO:1903237

HMNXSV003001880

HMNXSV003052906

Hs.218707.0.A1_3p_at

ILMN_1701347

ILMN_1774087

ILMN_2228845

PH_hs_0023859

TC05001317.hg

g10312151_3p_a_at

Participates

as a member of

CCL27,28 [extracellular region] (Homo sapiens)

Inferred To

CCL28 [extracellular region] (Bos taurus)

CCL28 [extracellular region] (Canis familiaris)

ccl44 [extracellular region] (Danio rerio)

Ccl28 [extracellular region] (Mus musculus)

Cross References

RefSeq

NP_001288803.1, NP_683513.1, NP_001288802.1

ENSEMBL

ENST00000361115, ENST00000489442, ENSP00000354416, ENSP00000426424

OpenTargets

ENSG00000151882

HPA

ENSG00000151882-CCL28

PRO

Q9NRJ3

Pharos - Targets

Q9NRJ3

GlyGen

Q9NRJ3

HMDB Protein

HMDBP07572

PDB

6CWS

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13501 CCL5	1	CCL5(24-91) [extracellular region] (R-HSA-373108)	0.558	2
UniProt:P48061 CXCL12	1	CXCL12(22-93) [extracellular region] (R-HSA-2980693)	0.558	2
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3