Reactome | Psma3 [nucleoplasm]

Psma3 [nucleoplasm]

Stable Identifier

R-RNO-174323

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

PSMA3, P18422

Locations in the PathwayBrowser

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Cell Cycle (Rattus norvegicus)

- Cell Cycle Checkpoints (Rattus norvegicus)
  - G1/S DNA Damage Checkpoints (Rattus norvegicus)
    - p53-Independent G1/S DNA Damage Checkpoint (Rattus norvegicus)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Rattus norvegicus)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Rattus norvegicus)
        
        26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        20S core particle [nucleoplasm] (Rattus norvegicus)
        
        20S CP outer ring [nucleoplasm] (Rattus norvegicus)
        
        Psma3 [nucleoplasm] (Rattus norvegicus)
- Cell Cycle, Mitotic (Rattus norvegicus)
  - Mitotic G1 phase and G1/S transition (Rattus norvegicus)
    - G1/S Transition (Rattus norvegicus)
      - Cyclin E associated events during G1/S transition (Rattus norvegicus)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Rattus norvegicus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Rattus norvegicus)
        
        26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        20S core particle [nucleoplasm] (Rattus norvegicus)
        
        20S CP outer ring [nucleoplasm] (Rattus norvegicus)
        
        Psma3 [nucleoplasm] (Rattus norvegicus)
  - Regulation of mitotic cell cycle (Rattus norvegicus)
    - APC/C-mediated degradation of cell cycle proteins (Rattus norvegicus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Rattus norvegicus)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Rattus norvegicus)
        
        26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        20S core particle [nucleoplasm] (Rattus norvegicus)
        
        20S CP outer ring [nucleoplasm] (Rattus norvegicus)
        
        Psma3 [nucleoplasm] (Rattus norvegicus)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Rattus norvegicus)
        
        Degradation of multiubiquitinated Cdh1 (Rattus norvegicus)
        
        26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        20S core particle [nucleoplasm] (Rattus norvegicus)
        
        20S CP outer ring [nucleoplasm] (Rattus norvegicus)
        
        Psma3 [nucleoplasm] (Rattus norvegicus)
  - S Phase (Rattus norvegicus)
    - Cyclin A:Cdk2-associated events at S phase entry (Rattus norvegicus)
      - SCF(Skp2)-mediated degradation of p27/p21 (Rattus norvegicus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Rattus norvegicus)
        
        26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        20S core particle [nucleoplasm] (Rattus norvegicus)
        
        20S CP outer ring [nucleoplasm] (Rattus norvegicus)
        
        Psma3 [nucleoplasm] (Rattus norvegicus)

Cellular responses to stimuli (Rattus norvegicus)

- Cellular responses to stress (Rattus norvegicus)
  - Cellular response to chemical stress (Rattus norvegicus)
    - KEAP1-NFE2L2 pathway (Rattus norvegicus)
      - Nuclear events mediated by NFE2L2 (Rattus norvegicus)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Rattus norvegicus)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Rattus norvegicus)
        
        26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        20S core particle [nucleoplasm] (Rattus norvegicus)
        
        20S CP outer ring [nucleoplasm] (Rattus norvegicus)
        
        Psma3 [nucleoplasm] (Rattus norvegicus)

Gene expression (Transcription) (Rattus norvegicus)

- RNA Polymerase II Transcription (Rattus norvegicus)
  - Generic Transcription Pathway (Rattus norvegicus)
    - Transcriptional regulation by RUNX3 (Rattus norvegicus)
      - Regulation of RUNX3 expression and activity (Rattus norvegicus)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Rattus norvegicus)
        
        26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        20S core particle [nucleoplasm] (Rattus norvegicus)
        
        20S CP outer ring [nucleoplasm] (Rattus norvegicus)
        
        Psma3 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P18422

Gene Names

Psma3

Reference Genes

BioGPS Gene:29670 Psma3

ENSEMBL:ENSRNOG00000007851

ENSEMBL:ENSRNOG00055009458

ENSEMBL:ENSRNOG00060006748

ENSEMBL:ENSRNOG00065007205

KEGG:rno:29670 Psma3

Monarch:29670 Psma3

NCBI Gene:29670 Psma3

UCSC:P18422 Psma3

Reference Transcript

RefSeq:NM_017280.2 Psma3

Other Identifiers

10745271

10885045

1368507_at

1368508_at

1382703_at

17816362

29670

408248

5681290

5754215

5781853

5789054

5793344

5813399

5883126

5924713

6072805

6355540

6448800

6456022

6462149

6508244

6522221

6579219

6610680

6674427

6678862

A_44_P383411

A_44_P650755

A_44_P720804

A_64_P045028

A_64_P071223

D90258_s_at

GE12457

GE20470

GO:0005839

GO:0006511

GO:0019773

GO:0051603

ILMN_1350746

PH_rn_0015781

PH_rn_0024020

PH_rn_0024021

rc_AA849028_at

rc_AI008546_at

rc_AI043864_at

Participates

as a component of

20S CP outer ring [nucleoplasm] (Rattus norvegicus)

Other forms of this molecule

Psma3 [cytosol]

Inferred From

PSMA3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_058976.1

ENSEMBL

ENSRNOP00000084525, ENSRNOG00000007851, ENSRNOT00000105733

PRO

P18422

RGD

61844

PDB

6EPC, 6EPD, 6EPE, 6EPF, 6TU3

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