Reactome | KLK5 [extracellular region]

KLK5 [extracellular region]

Stable Identifier

R-HSA-8849629

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

KLK5(67-293), Kallikrein-5, SCTE, Stratum corneum tryptic enzyme

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
10514489	Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation Brattsand, M, Egelrud, T	J. Biol. Chem.	1999
17881000	Structural basis of the zinc inhibition of human tissue kallikrein 5 Debela, M, Goettig, P, Magdolen, V, Huber, R, Schechter, NM, Bode, W	J. Mol. Biol.	2007

External Reference Information

External Reference

UniProt:Q9Y337 KLK5

Gene Names

KLK5, SCTE, UNQ570/PRO1132

Chain

signal peptide:1-22, chain:23-293

Reference Genes

BioGPS Gene:25818 KLK5

COSMIC (genes):KLK5 KLK5

CTD Gene:25818 KLK5

dbSNP Gene:25818 KLK5

ENSEMBL:ENSG00000167754 KLK5

HGNC:6366 KLK5

KEGG:hsa:25818 KLK5

Monarch:25818 KLK5

NCBI Gene:25818 KLK5

OMIM:605643 KLK5

UCSC:Q9Y337 KLK5

Reference Transcript

Other Identifiers

11728024_a_at

16874683

222242_PM_s_at

222242_s_at

25818

3868754

3868755

3868756

3868757

3868759

3868760

3868761

3868762

3868763

3868764

3868765

3868766

3868767

46897_at

8038670

A_23_P153480

GE58494

GO:0002803

GO:0004252

GO:0005515

GO:0005576

GO:0005615

GO:0005829

GO:0006508

GO:0008233

GO:0008236

GO:0008544

GO:0016787

GO:0022617

GO:0030141

GO:0030198

GO:0045745

GO:0048856

GO:0051604

GO:0070268

GO:0097186

GO:0097209

HMNXSV003005430

Hs.50915.1.S1_3p_a_at

ILMN_1718731

ILMN_2264029

ILMN_2353054

PH_hs_0003518

TC19001763.hg

Participates

as a component of

as an input of

as an output of

Other forms of this molecule

proKLK5 [extracellular region]

KLK5 propeptide [extracellular region]

KLK5 [cytosol]

Inferred To

LOC101750376 [extracellular region] (Gallus gallus)

Klk5 [extracellular region] (Mus musculus)

Klk5 [extracellular region] (Rattus norvegicus)

KLK5 [extracellular region] (Bos taurus)

KLK5 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_001070959.1, XP_011525005.1, XP_011525004.1, NP_036559.1, XP_054176448.1, XP_054176447.1, NP_001070960.1

Guide to Pharmacology - Targets

2375

OpenTargets

ENSG00000167754

ENSEMBL

ENSP00000471966, ENSP00000337733, ENST00000336334, ENST00000593428, ENST00000391809, ENSP00000375685, ENSG00000167754

ZINC - Substances

KLK5_HUMAN

ZINC target

Q9Y337

PRO

Q9Y337

GlyGen

Q9Y337

PDB

2PSX, 6QFE, 2PSY, 7U5B

HPA

ENSG00000167754-KLK5

GeneCards

KLK5

Pharos - Targets

Q9Y337

ZINC - Predictions - Purchasable

KLK5_HUMAN

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:A4D1U4 DEN11			0.643	3
UniProt:Q9Y4K0 LOXL2	3	LOXL2(26-?) [extracellular region] (R-HSA-2022106) LOXL2 [extracellular region] (R-HSA-2022142) LOXL2(?-774) [extracellular region] (R-HSA-2022136)	0.643	4
UniProt:Q86XX4 FRAS1			0.643	4
UniProt:P20930 FLG	2	FLG(?-?) [cytosol] (R-HSA-6810859) FLG(1-4061) [cytosol] (R-HSA-8849818)	0.572	4
UniProt:Q9NQG1 MANBL			0.556	3
UniProt:P11245 NAT2	2	AcC-NAT2 [cytosol] (R-HSA-158833) NAT2 [cytosol] (R-HSA-158692)	0.527	2
UniProt:P57076 CF298			0.527	2
UniProt:Q71U36 TUBA1A	9	TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433) TUBA1A(1-450) [cytosol] (R-HSA-8955577) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) TUBA1A unfolded [cytosol] (R-HSA-392767) TUBA1A folding intermediate [cytosol] (R-HSA-392805) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) AcK-TUBA1A [cytosol] (R-HSA-5618312)	0.527	3
UniProt:O60245 PCDH7	2	PCDH7 [plasma membrane] (R-HSA-8848879) PCDH7 [platelet alpha granule membrane] (R-HSA-8848917)	0.527	2
UniProt:Q9Y6N1 COX11	1	COX11 [mitochondrial inner membrane] (R-HSA-5336155)	0.527	2
UniProt:P02794 FTH1	5	FTH1 [cytosol] (R-HSA-434212) FTH1 [extracellular region] (R-HSA-2187212) FTH1 [endocytic vesicle lumen] (R-HSA-2299670) FTH1 [tertiary granule lumen] (R-HSA-6801508) FTH1 [ficolin-1-rich granule lumen] (R-HSA-6801531)	0.527	2
UniProt:Q13509 TUBB3	6	TUBB3 [cytosol] (R-HSA-190532) TUBB3 [axonemal microtubule] (R-HSA-5610436) Polyglutamyl-TUBB3 [cytosol] (R-HSA-8867464) Polyglycyl-TUBB3 [cytosol] (R-HSA-8867372) TUBB3 unfolded [cytosol] (R-HSA-392770) TUBB3 folding intermediate [cytosol] (R-HSA-392806)	0.527	3
UniProt:P03886 MT-ND1	1	MT-ND1 [mitochondrial inner membrane] (R-HSA-60551)	0.527	2
UniProt:Q96EM0 T3HPD			0.527	2
UniProt:P18084 ITGB5	2	ITGB5 [phagocytic vesicle] (R-HSA-1236749) ITGB5 [plasma membrane] (R-HSA-215948)	0.527	2
UniProt:Q3ZCM7 TUBB8	3	Polyglycyl-TUBB8 [cytosol] (R-HSA-8867423) Polyglutamyl-TUBB8 [cytosol] (R-HSA-8867387) TUBB8 [cytosol] (R-HSA-6805243)	0.527	3
UniProt:P68366 TUBA4A	9	TUBA4A [cytosol] (R-HSA-191694) TUBA4A [axonemal microtubule] (R-HSA-5610443) TUBA4A [extracellular region] (R-HSA-350734) Polyglutamyl-TUBA4A [cytosol] (R-HSA-8867386) L-isoglutamyl polyglycyl-TUBA4A [cytosol] (R-HSA-8867378) TUBA4A unfolded [cytosol] (R-HSA-392771) TUBA4A folding intermediate [cytosol] (R-HSA-392800) Ac K40 TUBA4A [axonemal microtubule] (R-HSA-5624859) AcK-TUBA4A [cytosol] (R-HSA-5618318)	0.527	3
UniProt:Q8IUF1 ZNG1B			0.527	2
UniProt:P15289 ARSA	9	ARSA(19-444) [endoplasmic reticulum lumen] (R-HSA-1614334) ARSA(448-507) [endoplasmic reticulum lumen] (R-HSA-1614307) OxA-ARSA(19-444) [endoplasmic reticulum lumen] (R-HSA-1614359) OxA-ARSA(19-444) [lysosomal lumen] (R-HSA-508497) ARSA(448-507) [lysosomal lumen] (R-HSA-1606798) ARSA(448-507) [azurophil granule lumen] (R-HSA-6798775) ARSA(19-444) [azurophil granule lumen] (R-HSA-6798776) ARSA(448-507) [extracellular region] (R-HSA-6806249) ARSA(19-444) [extracellular region] (R-HSA-6806192)	0.527	2
UniProt:Q92572 AP3S1	2	AP3S1 [Golgi membrane] (R-HSA-434343) AP3S1 [cytoplasmic vesicle membrane] (R-HSA-434205)	0.527	2
UniProt:O75581 LRP6	8	LRP6 [plasma membrane] (R-HSA-206252) p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-1458895) p-2S,S1490,2T-LRP6 [plasma membrane] (R-HSA-1458894) LRP6N [extracellular region] (R-HSA-5334021) p-LRP6 [early endosome membrane] (R-HSA-5368496) LRP6 [early endosome membrane] (R-HSA-5368481) p-S1490-LRP6 [plasma membrane] (R-HSA-206156) p-T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-205884)	0.527	2
UniProt:P30281 CCND3	2	CCND3 [nucleoplasm] (R-HSA-113835) CCND3 [cytosol] (R-HSA-68333)	0.527	2
UniProt:P56282 POLE2	1	POLE2 [nucleoplasm] (R-HSA-68482)	0.527	2

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