Reactome | ITGB5 [plasma membrane]

ITGB5 [plasma membrane]

Stable Identifier

R-HSA-215948

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Integrin beta-5

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by TGFB family members (Homo sapiens)
  - Signaling by TGF-beta Receptor Complex (Homo sapiens)
    - TGF-beta receptor signaling activates SMADs (Homo sapiens)
      - Latent TGF-beta-1 binds integrins (Homo sapiens)
        
        LAP1 binding-integrins [plasma membrane] (Homo sapiens)
        
        Integrin alphaVbeta5 [plasma membrane] (Homo sapiens)
        
        ITGB5 [plasma membrane] (Homo sapiens)
        
        LTBP1:TGFB1:LAP1:LAP1-binding integrins [plasma membrane] (Homo sapiens)
        
        LAP1 binding-integrins [plasma membrane] (Homo sapiens)
        
        Integrin alphaVbeta5 [plasma membrane] (Homo sapiens)
        
        ITGB5 [plasma membrane] (Homo sapiens)
      - Latent TGF-beta-3 binds integrins (Homo sapiens)
        
        LAP3-binding integrins [plasma membrane] (Homo sapiens)
        
        Integrin alphaVbeta5 [plasma membrane] (Homo sapiens)
        
        ITGB5 [plasma membrane] (Homo sapiens)
        
        TGF-beta-3:LAP3:LAP3-binding integrins [plasma membrane] (Homo sapiens)
        
        LAP3-binding integrins [plasma membrane] (Homo sapiens)
        
        Integrin alphaVbeta5 [plasma membrane] (Homo sapiens)
        
        ITGB5 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P18084 ITGB5

Gene Names

ITGB5

Chain

signal peptide:1-23, chain:24-799

Reference Genes

BioGPS Gene:3693 ITGB5

COSMIC - genes:ITGB5 ITGB5

CTD Gene:3693 L7RT22

dbSNP Gene:3693 ITGB5

ENSEMBL:ENSG00000082781 ITGB5

HGNC:6160 ITGB5

KEGG:hsa:3693 ITGB5

Monarch:3693 ITGB5

NCBI Gene:3693 ITGB5

OMIM:147561 ITGB5

UCSC:P18084 ITGB5

Reference Transcript

RefSeq:NM_002213.4 ITGB5

Other Identifiers

11754810_a_at

16958356

201124_PM_at

201124_at

201125_PM_s_at

201125_s_at

2058_s_at

214020_PM_x_at

2692817

2692818

2692819

2692820

2692821

2692823

2692824

2692825

2692826

2692827

2692831

2692836

2692839

2692840

2692844

2692845

2692846

2692847

2692848

2692849

2692850

2692853

2692859

2692864

2692865

2692866

2692867

2692868

2692869

2692870

2692871

2692876

2692878

2692884

3693

39754_at

8090162

A_23_P166633

GE59781

GO:0001618

GO:0001704

GO:0005102

GO:0005178

GO:0005515

GO:0005886

GO:0005925

GO:0007155

GO:0007160

GO:0007179

GO:0007229

GO:0008305

GO:0009986

GO:0016020

GO:0016477

GO:0030154

GO:0031410

GO:0033627

GO:0034684

GO:0035313

GO:0035987

GO:0043149

GO:0043235

GO:0045335

GO:0046718

GO:0046872

GO:0048870

GO:0070062

GO:0090136

GO:0098609

HMNXSV003047937

Hs.149846.0.S2_3p_at

Hs.149846.1.S1_3p_a_at

ILMN_1668374

ILMN_1701619

ILMN_1761674

ILMN_1796755

ILMN_2311166

J05633_at

PH_hs_0009022

TC03001717.hg

X53002_s_at

g4504772_3p_a_at

Participates

as a component of

Other forms of this molecule

ITGB5 [phagocytic vesicle]

Inferred To

pat-3 [plasma membrane] (Caenorhabditis elegans)

itgb5 [plasma membrane] (Danio rerio)

itgb5 [plasma membrane] (Xenopus tropicalis)

ITGB5 [plasma membrane] (Bos taurus)

ITGB5 [plasma membrane] (Canis familiaris)

ITGB5 [plasma membrane] (Gallus gallus)

ITGB5 [plasma membrane] (Mus musculus)

ITGB5 [plasma membrane] (Rattus norvegicus)

ITGB5 [plasma membrane] (Sus scrofa)

mys [plasma membrane] (Drosophila melanogaster)

Homologues of ITGB5 [plasma membrane] (Drosophila melanogaster)

Itgbn [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_002204.2

Guide to Pharmacology - Targets

2459

ENSEMBL

ENSP00000296181, ENST00000296181, ENSG00000082781

OpenTargets

ENSG00000082781

GeneCards

ITGB5

HPA

ENSG00000082781-ITGB5

PRO

P18084

Pharos - Targets

P18084

GlyGen

P18084

PDB

7S46, 7S47, 7S48

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04004 VTN	1	VTN [extracellular region] (R-HSA-215971)	0.643	3
UniProt:Q9BY76 ANGPTL4	3	ANGPTL4 [extracellular region] (R-HSA-381271) ANGPTL4 [extracellular region] (R-HSA-6784897) ANGPTL4(164-406) [extracellular region] (R-HSA-9762251)	0.564	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:P97479 Myo7a	1	Myo7a [cytosol] (R-MMU-9658865)	0.544	8
UniProt:Q9HD67 MYO10	1	MYO10 [cytosol] (R-HSA-593679)	0.544	2
UniProt:Q9Y337 KLK5	4	KLK5 [extracellular region] (R-HSA-8849629) proKLK5 [extracellular region] (R-HSA-8849836) KLK5 propeptide [extracellular region] (R-HSA-8849839) KLK5 [cytosol] (R-HSA-8934778)	0.527	2

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