Reactome | MT-ND1 [mitochondrial inner membrane]

MT-ND1 [mitochondrial inner membrane]

Stable Identifier

R-HSA-60551

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH-ubiquinone oxidoreductase chain 1 (EC 1.6.5.3)

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External Reference Information

External Reference

UniProt:P03886 MT-ND1

Gene Names

MT-ND1, MTND1, NADH1, ND1

Chain

chain:1-318

Reference Genes

BioGPS Gene:4535 MT-ND1

COSMIC (genes):MT-ND1 MT-ND1

CTD Gene:4535 MT-ND1

dbSNP Gene:4535 MT-ND1

ENSEMBL:ENSG00000198888 MT-ND1

HGNC:7455 MT-ND1

KEGG:hsa:4535 MT-ND1

Monarch:4535 MT-ND1

NCBI Gene:4535 MT-ND1

OMIM:516000 MT-ND1

UCSC:P03886 MT-ND1

Reference Transcript

RefSeq:NC_012920.1 MT-ND1

Other Identifiers

11761514_at

11761515_s_at

11761516_x_at

1553551_3p_s_at

1553551_PM_s_at

1553551_s_at

17100647

17100649

17100651

17100653

17126274

2315304

2315305

2315306

2315307

2315308

2315309

4037590

4037592

4037594

4037596

4037597

4037598

4037599

4037600

4037601

4037603

4037605

4037607

4037609

4037610

4037611

4535

7896746

8165653

8165656

ADDON000548.hg

ADDON001198.hg

A_23_P331028

A_23_P431853

A_24_P182122

GO:0001666

GO:0003824

GO:0003954

GO:0005215

GO:0005515

GO:0005739

GO:0005743

GO:0006091

GO:0006120

GO:0008137

GO:0009060

GO:0009410

GO:0014070

GO:0016020

GO:0016491

GO:0030425

GO:0031966

GO:0032981

GO:0033194

GO:0042776

GO:0043025

GO:0043226

GO:0045271

GO:0055085

GO:0055086

GO:0065003

GO:1901135

GO:1902600

HMNXSV003012672

HMNXSV003044876

Hs2Affx.1.29.S1_3p_s_at

RNA143501|tRNA_418_69

RNA143567

RNA147405|p0509_imsncRNA82

TC01004109.hg

TC0M000003.hg

Participates

as a member of

Substrate of YME1L1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)

as an input of

Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)

as a component of

Inferred To

ND1 [mitochondrial inner membrane] (Bos taurus)

mt:ND1 [mitochondrial inner membrane] (Drosophila melanogaster)

Mtnd1 [mitochondrial inner membrane] (Mus musculus)

mt-nd1 [mitochondrial inner membrane] (Danio rerio)

mt-nd1 [mitochondrial inner membrane] (Xenopus tropicalis)

Mt-nd1 [mitochondrial inner membrane] (Rattus norvegicus)

nduo-1 [mitochondrial inner membrane] (Caenorhabditis elegans)

Ghost homologue of MT-ND1 [mitochondrial inner membrane] (Canis familiaris)

MT-ND1 [mitochondrial inner membrane] (Gallus gallus)

MT-ND1 [mitochondrial inner membrane] (Sus scrofa)

Cross References

ENSEMBL

ENSP00000354687

OpenTargets

ENSG00000198888

IntEnz

7.1.1.2

HPA

ENSG00000198888-MT-ND1

PRO

P03886

Pharos - Targets

P03886

GlyGen

P03886

Orphanet

MT-ND1

HMDB Protein

HMDBP00117

PDB

5XTC, 5XTD

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75489 NDUFS3	2	NDUFS3 [mitochondrial matrix] (R-HSA-163927) NDUFS3 [cytosol] (R-HSA-9714751)	0.643	3
UniProt:P51970 NDUFA8	1	NDUFA8 [mitochondrial inner membrane] (R-HSA-60627)	0.527	2
UniProt:Q9Y337 KLK5	4	KLK5 [extracellular region] (R-HSA-8849629) proKLK5 [extracellular region] (R-HSA-8849836) KLK5 propeptide [extracellular region] (R-HSA-8849839) KLK5 [cytosol] (R-HSA-8934778)	0.527	2
UniProt:O75380 NDUFS6	1	NDUFS6 [mitochondrial inner membrane] (R-HSA-163922)	0.527	4
UniProt:O14788 TNFSF11	2	TNFSF11 [plasma membrane] (R-HSA-5667141) sTNFSF11 [extracellular region] (R-HSA-5676547)	0.527	2
UniProt:Q9Y279 VSIG4			0.527	2
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	3
UniProt:O43920 NDUFS5	1	NDUFS5 [mitochondrial inner membrane] (R-HSA-60226)	0.527	2
UniProt:Q7KYR7 BTN2A1	1	BTN2A1 [plasma membrane] (R-HSA-8851994)	0.527	2
UniProt:P43490 NAMPT	1	NAMPT [cytosol] (R-HSA-197188)	0.508	3