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FLG(1-4061) [cytosol]
Stable Identifier
R-HSA-8849818
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Profilaggrin, FILA_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Developmental Cell Lineages (Homo sapiens)
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin (Homo sapiens)
Keratinocyte of granulosum layer differentiates into corneocyte of corneum layer in interfollicular epidermis (Homo sapiens)
corneocyte (Homo sapiens)
FLG(1-4061) [cytosol] (Homo sapiens)
keratinocyte of granulosum layer of epidermis (Homo sapiens)
FLG(1-4061) [cytosol] (Homo sapiens)
Keratinocyte of spinosum layer differentiates into keratinocyte of granulosum layer in interfollicular epidermis (Homo sapiens)
keratinocyte of granulosum layer of epidermis (Homo sapiens)
FLG(1-4061) [cytosol] (Homo sapiens)
Keratinization (Homo sapiens)
Formation of the cornified envelope (Homo sapiens)
Cytoplasmic proteases cleave Profilaggrin producing Filaggrin (Homo sapiens)
FLG(1-4061) [cytosol] (Homo sapiens)
Membrane proteases cleave Profilaggrin producing Filaggrin (Homo sapiens)
FLG(1-4061) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20930 FLG
Gene Names
FLG
Chain
chain:1-4061
Reference Genes
BioGPS Gene:2312 FLG
COSMIC (genes):FLG FLG
CTD Gene:2312 FLG
dbSNP Gene:2312 FLG
ENSEMBL:ENSG00000143631 FLG
HGNC:3748 FLG
Monarch:2312 FLG
NCBI Gene:2312 FLG
OMIM:135940 FLG
UCSC:P20930 FLG
Reference Transcript
RefSeq:NM_002016.1 FLG
Other Identifiers
11741116_at
16693308
215704_PM_at
215704_at
2312
2435560
2435562
2435564
2435566
2435568
2435570
2435572
2435574
2435576
2435578
2435579
2435580
2435581
2435582
2435583
2435584
2435586
2435588
2435590
2435592
2435594
2435596
2435598
2435600
2435602
2435604
2435606
2435608
2435610
2435612
2435614
2435616
2435618
2435620
2435622
2435624
2435626
2435628
2435630
2435632
2435634
2435636
2435638
2435640
2435642
2435644
2435646
2435648
2435651
31542_at
7920165
A_24_P34199
A_32_P387648
A_33_P3261328
GE551760
GO:0001533
GO:0005198
GO:0005509
GO:0005515
GO:0005634
GO:0005829
GO:0005886
GO:0018149
GO:0030154
GO:0030216
GO:0030280
GO:0030312
GO:0031012
GO:0036457
GO:0036464
GO:0043226
GO:0046872
GO:0046914
GO:0048856
GO:0061436
GO:0062023
HMNXSV003039689
Hs.73995.0.S1_3p_at
ILMN_1720695
ILMN_2134130
M60503_at
PH_hs_0034747
PH_hs_0041201
TC01003245.hg
TC01005828.hg
TC01005829.hg
TC01005830.hg
Participates
as a protein marker of
corneocyte (Homo sapiens)
keratinocyte of granulosum layer of epidermis (Homo sapiens)
as an input of
Cytoplasmic proteases cleave Profilaggrin producing Filaggrin (Homo sapiens)
Membrane proteases cleave Profilaggrin producing Filaggrin (Homo sapiens)
Other forms of this molecule
FLG(?-?) [cytosol]
Inferred To
FLG [cytosol]
(Canis familiaris)
Cross References
ENSEMBL
ENST00000368799
,
ENSP00000357789
OpenTargets
ENSG00000143631
HPA
ENSG00000143631-FLG
PRO
P20930
Pharos - Targets
P20930
GlyGen
P20930
Orphanet
FLG
PDB
4PCW
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y337 KLK5
4
KLK5 [extracellular region]
(R-HSA-8849629)
proKLK5 [extracellular region]
(R-HSA-8849836)
KLK5 propeptide [extracellular region]
(R-HSA-8849839)
KLK5 [cytosol]
(R-HSA-8934778)
0.572
4
UniProt:P02794 FTH1
5
FTH1 [cytosol]
(R-HSA-434212)
FTH1 [tertiary granule lumen]
(R-HSA-6801508)
FTH1 [extracellular region]
(R-HSA-2187212)
FTH1 [ficolin-1-rich granule lumen]
(R-HSA-6801531)
FTH1 [endocytic vesicle lumen]
(R-HSA-2299670)
0.527
2
UniProt:O75716 STK16
0.527
2
UniProt:Q92731 ESR2
5
ESR2 [cytosol]
(R-HSA-9020970)
ESR2 [nucleoplasm]
(R-HSA-446165)
Me-PalmS-ESR2 [plasma membrane]
(R-HSA-9637787)
PalmS-ESR2 [plasma membrane]
(R-HSA-9021059)
PalmS-ESR2 [cytosol]
(R-HSA-9020979)
0.527
2
UniProt:P55851 UCP2
1
UCP2 [mitochondrial inner membrane]
(R-HSA-166392)
0.527
2
UniProt:O43309 ZSC12
0.527
2
UniProt:Q9Y324 FCF1
1
FCF1 [nucleoplasm]
(R-HSA-6790672)
0.527
2
UniProt:Q14943 KIR3DS1
1
KIR3DS1 [plasma membrane]
(R-HSA-2159806)
0.527
2
UniProt:P57076 CF298
0.527
2
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