ST14 hydrolyzes and activates KLK5

Stable Identifier
R-HSA-8849826
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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ST14 hydrolyzes and activates KLK5
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ST14 (Suppressor of tumorigenicity 14, also known as matriptase) associated with the plasma membrane catalyzes the hydrolytic cleavage of proKLK5 (pro-Kallekrein-5) to yield active KLK5 enzyme. The activity of human ST14 enzyme is inferred from that of its well-characterized mouse homolog (Sales et al. 2010). Consistent with this inference, deficiencies of the human enzyme are associated with an ichthyosis syndrome (MIM 602400) as is a knockout mutation of mouse St14 (Alef et al. 2009).
Literature References
PubMed ID Title Journal Year
20657595 Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome

Sales, KU, Masedunskas, A, Bey, AL, Rasmussen, AL, Weigert, R, List, K, Szabo, R, Overbeek, PA, Bugge, TH

Nat. Genet. 2010
18843291 Ichthyosis, follicular atrophoderma, and hypotrichosis caused by mutations in ST14 is associated with impaired profilaggrin processing

Alef, T, Torres, S, Hausser, I, Metze, D, Türsen, U, Lestringant, GG, Hennies, HC

J. Invest. Dermatol. 2009
Participants
Input
Output
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as an event of
Catalyst Activity

serine-type endopeptidase activity of ST14 [plasma membrane]

Physical Entity
ST14 [plasma membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Inferred From
St14 hydrolyzes and activates Klk5 (Mus musculus)
Authored
Jupe, S  (2016-03-10)
Reviewed
Blumenberg, M  (2016-08-12)
Created
D'Eustachio, P  (2015-12-18)
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