ST14 hydrolyzes and activates KLK5

Stable Identifier
Reaction [transition]
Homo sapiens
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ST14 (Suppressor of tumorigenicity 14, also known as matriptase) associated with the plasma membrane catalyzes the hydrolytic cleavage of proKLK5 (pro-Kallekrein-5) to yield active KLK5 enzyme. The activity of human ST14 enzyme is inferred from that of its well-characterized mouse homolog (Sales et al. 2010). Consistent with this inference, deficiencies of the human enzyme are associated with an ichthyosis syndrome (MIM 602400) as is a knockout mutation of mouse St14 (Alef et al. 2009).

Literature References
PubMed ID Title Journal Year
20657595 Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome

Sales, KU, Weigert, R, Bey, AL, Bugge, TH, Szabo, R, List, K, Overbeek, PA, Rasmussen, AL, Masedunskas, A

Nat. Genet. 2010
18843291 Ichthyosis, follicular atrophoderma, and hypotrichosis caused by mutations in ST14 is associated with impaired profilaggrin processing

Lestringant, GG, Metze, D, Hausser, I, Alef, T, Hennies, HC, Türsen, U, Torres, S

J. Invest. Dermatol. 2009
Catalyst Activity

serine-type endopeptidase activity of ST14 [plasma membrane]

Inferred From
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