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POLE2 [nucleoplasm]
Stable Identifier
R-HSA-68482
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA polymerase epsilon subunit B , DNA polymerase II subunit B
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA replication initiation (Homo sapiens)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Homo sapiens)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Homo sapiens)
PCNA-Dependent Long Patch Base Excision Repair (Homo sapiens)
FEN1 bound to PCNA and APEX1 cleaves flap ssDNA (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
LIG1 binds APEX1 and PCNA at SSB (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
LIG1 bound to APEX1 and PCNA ligates SSB (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
POLD,POLE-mediated DNA strand displacement synthesis (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA Damage Bypass (Homo sapiens)
Recognition of DNA damage by PCNA-containing replication complex (Homo sapiens)
PCNA-containing replication complex binds damaged dsDNA (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)
Termination of translesion DNA synthesis (Homo sapiens)
POLD,POLE binds deISGylated PCNA after TLS (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
POLD,POLE complete replication of damaged DNA after TLS (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
D-loop extension by DNA polymerases (Homo sapiens)
PCNA:POLD,POLE,POLH,POLK:RPA:RFC [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
Dual Incision in GG-NER (Homo sapiens)
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
POLD,POLE,POLK [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in GG-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in GG-NER (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Dual incision in TC-NER (Homo sapiens)
3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
POLD,POLE,POLK [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA replication initiation (Homo sapiens)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Homo sapiens)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P56282 POLE2
Gene Names
POLE2, DPE2
Chain
chain:1-527
Reference Genes
BioGPS Gene:5427 POLE2
COSMIC (genes):POLE2 POLE2
CTD Gene:5427 POLE2
dbSNP Gene:5427 POLE2
ENSEMBL:ENSG00000100479 POLE2
ENSEMBL_homo_sapiens_GENE:ENSG00000100479.14 POLE2
HGNC:9178 POLE2
Monarch:5427 POLE2
NCBI Gene:5427 POLE2
OMIM:602670 POLE2
UCSC:P56282 POLE2
Reference Transcript
RefSeq:NM_002692.3 POLE2
RefSeq:NM_001197330.1 POLE2
RefSeq:NM_001348384.1 POLE2
RefSeq:NM_001197331.1 POLE2
Other Identifiers
11744519_a_at
16792519
205909_PM_at
205909_at
3563396
3563401
3563402
3563403
3563404
3563407
3563408
3563409
3563412
3563413
3563414
3563415
3563417
3563418
3563422
3563423
3563424
3563425
3563426
3563427
3563436
3563437
3563438
41085_at
5427
7978846
A_23_P163099
GE81181
GO:0000228
GO:0003677
GO:0003824
GO:0003887
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006260
GO:0006261
GO:0006281
GO:0008622
GO:0016604
GO:0016740
GO:0031981
GO:0042276
GO:0043226
GO:0043231
GO:0140097
HMNXSV003032006
ILMN_1774336
PH_hs_0005513
TC14001105.hg
g4505934_3p_at
Participates
as a component of
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
Inferred To
pole-2 [nucleoplasm]
(Caenorhabditis elegans)
PolE2 [nucleoplasm]
(Drosophila melanogaster)
Pole2 [nucleoplasm]
(Mus musculus)
Pole2 [nucleoplasm]
(Rattus norvegicus)
dpb2 [nucleoplasm]
(Schizosaccharomyces pombe)
DPB2 [nucleoplasm]
(Saccharomyces cerevisiae)
POLE2 [nucleoplasm]
(Bos taurus)
POLE2 [nucleoplasm]
(Canis familiaris)
POLE2 [nucleoplasm]
(Gallus gallus)
POLE2 [nucleoplasm]
(Plasmodium falciparum)
POLE2 [nucleoplasm]
(Sus scrofa)
pole2 [nucleoplasm]
(Dictyostelium discoideum)
pole2 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001184259.1
,
NP_001335313.1
,
NP_001184260.1
,
NP_002683.2
OpenTargets
ENSG00000100479
GeneCards
P56282
HPA
ENSG00000100479-POLE2
Ensembl
ENSP00000446313
,
ENST00000554396
,
ENSG00000100479
,
ENSP00000451621
,
ENST00000539565
,
ENST00000216367
,
ENSP00000216367
PRO
P56282
Pharos - Targets
P56282
Orphanet
28531
HMDB Protein
HMDBP00970
PDB
7PLO
,
5VBN
,
7PFO
,
2V6Z
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.781
7
UniProt:P52594 AGFG1
1
AGFG1 [cytosol]
(R-HSA-8863714)
0.556
3
UniProt:O96006 ZBED1
1
ZBED1 [nucleoplasm]
(R-HSA-8956376)
0.556
3
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