Reactome | LRP6N [extracellular region]

LRP6N [extracellular region]

Stable Identifier

R-HSA-5334021

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

LRP6 extracellular domain

Icon

General

represents an experimentally engineered, plasmid encoded fragment of the LRP6 extracellular domain up to 2 residues before the putative transmembrane domain

Literature References

PubMed ID	Title	Journal	Year
11029007	LDL-receptor-related proteins in Wnt signal transduction Tamai, K, Semenov, M, Kato, Y, Spokony, R, Liu, C, Katsuyama, Y, Hess, F, Saint-Jeannet, JP, He, X	Nature	2000

External Reference Information

External Reference

UniProt:O75581 LRP6

Gene Names

LRP6

Chain

signal peptide:1-19, chain:20-1613

Reference Genes

BioGPS Gene:4040 LRP6

COSMIC (genes):LRP6 LRP6

CTD Gene:4040 LRP6

dbSNP Gene:4040 LRP6

ENSEMBL:ENSG00000070018 LRP6

HGNC:6698 LRP6

KEGG:hsa:4040 LRP6

Monarch:4040 LRP6

NCBI Gene:4040 LRP6

OMIM:603507 LRP6

UCSC:O75581 LRP6

Reference Transcript

Other Identifiers

11719256_a_at

11719257_s_at

11751922_a_at

16761583

205606_PM_at

205606_at

225745_PM_at

225745_at

2603590

2603591

2603596

2872495

3404113

3404115

3404116

3404117

3444817

3444819

3444821

3444822

3444823

3444824

3444825

3444826

3444829

3444830

3444831

3444832

3444833

3444834

3444835

3444836

3444837

3444838

3444839

3444841

3444844

3444846

3444847

3444848

3444849

3444851

3444855

3444857

3444858

3444859

3444861

3444862

3444872

3444873

3444880

3444888

3444889

3444890

3444891

3444892

3444893

3444894

34697_PM_at

34697_at

3519478

3519482

3576857

4040

4869269_3p_s_at

52017_at

7961339

79842_at

A_23_P150827

A_23_P392457

A_33_P3306948

GE79114

GO:0005041

GO:0005102

GO:0005109

GO:0005515

GO:0005576

GO:0005768

GO:0005769

GO:0005783

GO:0005794

GO:0005886

GO:0005901

GO:0006355

GO:0006897

GO:0007204

GO:0007268

GO:0007399

GO:0009888

GO:0009986

GO:0014029

GO:0014033

GO:0015026

GO:0016020

GO:0016055

GO:0016192

GO:0017147

GO:0019210

GO:0019534

GO:0030154

GO:0030291

GO:0030901

GO:0031410

GO:0031901

GO:0034392

GO:0038024

GO:0042802

GO:0042803

GO:0042813

GO:0042981

GO:0043009

GO:0043025

GO:0043434

GO:0045121

GO:0045202

GO:0045787

GO:0045893

GO:0045944

GO:0048646

GO:0048856

GO:0055085

GO:0060070

GO:0071397

GO:0071542

GO:0072659

GO:0098609

GO:0098772

GO:1904948

GO:1990851

GO:1990909

HMNXSV003031613

HMNXSV003048557

Hs.41269.0.A1_3p_at

ILMN_1732913

PH_hs_0023059

PH_hs_0039197

TC12001251.hg

TC12002769.hg

Participates

as a component of

mFzd8CRD:LRP6N [extracellular region] (Homo sapiens)

as an input of

mFz8CRD binds LRP6N in vitro (Homo sapiens)

Other forms of this molecule

LRP6 [plasma membrane]

p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane]

p-2S,S1490,2T-LRP6 [plasma membrane]

p-LRP6 [early endosome membrane]

LRP6 [early endosome membrane]

p-S1490-LRP6 [plasma membrane]

p-T1479,S1490,T1493-LRP6 [plasma membrane]

Cross References

RefSeq

NP_002327.2, NP_001401174.1, XP_006719141.1

OpenTargets

ENSG00000070018

ENSEMBL

ENST00000261349, ENSG00000281324, ENSG00000070018, ENST00000628182, ENSP00000261349, ENSP00000486315

GeneCards

LRP6

HPA

ENSG00000070018-LRP6

PRO

O75581

Pharos - Targets

O75581

GlyGen

O75581

Orphanet

LRP6

PDB

3S2K, 6H16, 6H15, 3S94, 5FWW, 4DG6, 5GJE, 5AIR, 4NM5, 3S8Z, 7NAM, 8DVM, 8CTG, 8DVL, 4NM7, 3SOQ, 6L6R, 3SOB, 3SOV, 8FFE, 8S7C, 3S8V, 8DVN, 4A0P

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O94907 DKK1	2	DKK1 [early endosome membrane] (R-HSA-5368462) DKK1 [extracellular region] (R-HSA-452535)	0.94	18
UniProt:Q9BQB4 SOST	1	SOST [extracellular region] (R-HSA-3769322)	0.887	10
UniProt:P56704 WNT3A	10	N4GlycoAsn-PalmS WNT3A [plasma membrane] (R-HSA-3247807) N4GlycoAsn-PalmS WNT3A [extracellular region] (R-HSA-3247784) N4GlycoAsn-PalmS WNT3A [Golgi lumen] (R-HSA-3247832) N4GlycoAsn-PalmS WNT3A [endoplasmic reticulum lumen] (R-HSA-3238344) N4GlycoAsn-WNT3A [endoplasmic reticulum lumen] (R-HSA-3238231) WNT3A [endoplasmic reticulum lumen] (R-HSA-3238292) N4GlycoAsn-PalmS WNT3A [early endosome membrane] (R-HSA-5368483) N4GlycoAsn-PalmS WNT3A [endocytic vesicle membrane] (R-HSA-3781944) N4GlycoAsn-PalmS WNT3A [extracellular exosome] (R-HSA-3781968) WNT3A [extracellular region] (R-HSA-201710)	0.77	4
UniProt:Q9H5K3 POMK	1	POMK [endoplasmic reticulum membrane] (R-HSA-8879120)	0.725	5
UniProt:P41212 ETV6	14	ETV6(1-384)-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703308) ETV6(1-154)insGSFILG-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703302) ETV6(1-336)insGCS-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703305) ETV6(1-301)-p-6Y-FLT3(574-993) fusion [cytosol] (R-HSA-9703318) ETV6(1-384)-p-3Y-FLT3(659-1620) fusion [cytosol] (R-HSA-9703313) ETV6(1-154)insGSFILG-FLT3(573-993) fusion [cytosol] (R-HSA-9703312) ETV6(1-336)insGCS-FLT3(573-993) fusion [cytosol] (R-HSA-9703320) ETV6(1-384)-FLT3(573-993) fusion [cytosol] (R-HSA-9703307) ETV6(1-301)-FLT3(574-993) fusion [cytosol] (R-HSA-9703315) ETV6(1-384)-FLT3(569-993) fusion [cytosol] (R-HSA-9697944) ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane] (R-HSA-9673898) ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane] (R-HSA-9673893) p-11Y-ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane] (R-HSA-9673905) p-12Y-ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane] (R-HSA-9673912)	0.725	4
UniProt:P27467 Wnt3a	12	Wnt3a [extracellular exosome] (R-MMU-3781968) Wnt3a [endocytic vesicle membrane] (R-MMU-3781944) N4GlycoAsn-PalmS Wnt3a [extracellular region] (R-MMU-3769340) Wnt3a [extracellular region] (R-MMU-3772390) Wnt3a [early endosome membrane] (R-MMU-5368483) N4GlycoAsn-PalmS Wnt3a [endoplasmic reticulum lumen] (R-MMU-3238346) N-glycosyl Wnt3a [endoplasmic reticulum lumen] (R-MMU-3238233) Wnt3a [endoplasmic reticulum lumen] (R-MMU-3238294) Wnt3a [endoplasmic reticulum lumen] (R-MMU-3238344) Wnt3a [Golgi lumen] (R-MMU-3247832) Wnt3a [extracellular region] (R-MMU-3247784) Wnt3a [plasma membrane] (R-MMU-3247807)	0.713	4
UniProt:Q61091 Fzd8	4	Fzd8 [plasma membrane] (R-MMU-4641183) Fzd8 [plasma membrane] (R-MMU-443947) mFz8CRD [extracellular region] (R-MMU-1458870) Fzd8 [plasma membrane] (R-MMU-517517)	0.702	4
UniProt:O75581 LRP6	8	LRP6 [plasma membrane] (R-HSA-206252) p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-1458895) p-2S,S1490,2T-LRP6 [plasma membrane] (R-HSA-1458894) LRP6N [extracellular region] (R-HSA-5334021) p-LRP6 [early endosome membrane] (R-HSA-5368496) LRP6 [early endosome membrane] (R-HSA-5368481) p-S1490-LRP6 [plasma membrane] (R-HSA-206156) p-T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-205884)	0.676	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.657	4
UniProt:P49841 GSK3B	5	GSK3B [nucleoplasm] (R-HSA-2022823) GSK3B [cytosol] (R-HSA-2997551) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [endoplasmic reticulum lumen] (R-HSA-9931408) GSK3B del304-316 [cytosol] (R-HSA-5339682)	0.656	4
UniProt:P49840 GSK3A	3	GSK3A [cytosol] (R-HSA-198326) p-S21-GSK3A [cytosol] (R-HSA-198352) p-Y279-GSK3A [cytosol] (R-HSA-9635490)	0.646	3
UniProt:Q7L1S5 CHST9			0.643	3
UniProt:Q8IUE0 TF2LY			0.643	3
UniProt:O70239	5	Axin1 [cytosol] (R-RNO-4641133) phospho-Axin1 [cytosol] (R-RNO-3640841) phospho-Axin1 [cytosol] (R-RNO-3640864) phospho-Axin1 [cytosol] (R-RNO-206040) Axin1 [cytosol] (R-RNO-195249)	0.602	12
UniProt:Q9UBU2 DKK2	2	DKK2 [early endosome membrane] (R-HSA-5368464) DKK2 [extracellular region] (R-HSA-3769326)	0.59	4
UniProt:O35625 Axin1	8	Axin1 [cytosol] (R-MMU-195249) phospho-Axin1 [cytosol] (R-MMU-206040) Phospho (3 sites) Axin1 [cytosol] (R-MMU-205737) Axin1 [cytosol] (R-MMU-205727) phospho-Axin1 [cytosol] (R-MMU-3640864) phospho-Axin1 [cytosol] (R-MMU-3640841) Axin1 [cytosol] (R-MMU-4641133) Phospho Axin1 [cytosol] (R-MMU-206175)	0.589	2
UniProt:P04426 Wnt1	9	Proto-oncogene Wnt-1 [extracellular region] (R-MMU-976238) Wnt1 [extracellular exosome] (R-MMU-3781965) Wnt1 [endocytic vesicle membrane] (R-MMU-3781952) N-glycosyl Wnt1 [endoplasmic reticulum lumen] (R-MMU-3238216) Wnt1 [endoplasmic reticulum lumen] (R-MMU-3238274) Wnt1 [endoplasmic reticulum lumen] (R-MMU-3238370) Wnt1 [Golgi lumen] (R-MMU-3247808) Wnt1 [extracellular region] (R-MMU-3247804) Wnt1 [plasma membrane] (R-MMU-3247789)	0.589	2
UniProt:Q5XG87 TENT4A	3	TENT4A [nucleolus] (R-HSA-9935840) PAPD7(1-653)-RAF1(331-648) fusion [cytosol] (R-HSA-6802430) PAPD7(1-653)-p-RAF1(331-648) fusion [cytosol] (R-HSA-6802541)	0.589	2
UniProt:Q9Y4X0 AMMR1			0.576	5
UniProt:Q9UBR5 CKLF			0.556	3
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [endocytic vesicle membrane] (R-HSA-535009) CAV1 [early endosome membrane] (R-HSA-5368451)	0.556	3
UniProt:Q9UK85 DKKL1			0.527	2
UniProt:O95968 SG1D1			0.527	2
UniProt:Q9Y337 KLK5	4	KLK5 [extracellular region] (R-HSA-8849629) proKLK5 [extracellular region] (R-HSA-8849836) KLK5 propeptide [extracellular region] (R-HSA-8849839) KLK5 [cytosol] (R-HSA-8934778)	0.527	2
UniProt:Q9UBM8 MGAT4C	1	MGAT4C [Golgi membrane] (R-HSA-975907)	0.527	2
UniProt:Q9Y6H6 KCNE3	1	KCNE3 [plasma membrane] (R-HSA-977536)	0.527	2
UniProt:O00744 WNT10B	9	WNT10B [extracellular region] (R-HSA-517471) N4GlycoAsn-PalmS WNT10B [extracellular exosome] (R-HSA-3781957) N4GlycoAsn-PalmS WNT10B [endocytic vesicle membrane] (R-HSA-3781985) WNT10B [endoplasmic reticulum lumen] (R-HSA-3238279) N4GlycoAsn-WNT10B [endoplasmic reticulum lumen] (R-HSA-3238220) N4GlycoAsn-PalmS WNT10B [endoplasmic reticulum lumen] (R-HSA-3238333) N4GlycoAsn-PalmS WNT10B [Golgi lumen] (R-HSA-3247821) N4GlycoAsn-PalmS WNT10B [extracellular region] (R-HSA-3247775) N4GlycoAsn-PalmS WNT10B [plasma membrane] (R-HSA-3247791)	0.527	2
UniProt:P08311 CTSG	4	CTSG [cytosol] (R-HSA-9635429) CTSG [plasma membrane] (R-HSA-538738) CTSG [extracellular region] (R-HSA-2228716) CTSG [azurophil granule lumen] (R-HSA-6799137)	0.527	2
UniProt:Q9Y2Y8 PRG3	3	PRG3 [specific granule lumen] (R-HSA-6799555) PRG3 [extracellular region] (R-HSA-6806299) PRG3 [tertiary granule lumen] (R-HSA-6800905)	0.527	2
UniProt:A4D1T9 PRS37			0.527	2
UniProt:Q96D21 RHES			0.527	3
UniProt:O15169 AXIN1	11	AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) RibC-AXIN1 [cytosol] (R-HSA-3640841) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.527	9
UniProt:Q9BZ11 ADAM33	1	ADAM33 [plasma membrane] (R-HSA-708324)	0.527	2
UniProt:P98082 DAB2	3	DAB2 [plasma membrane] (R-HSA-2980808) DAB2 [lysosomal membrane] (R-HSA-2980807) DAB2 [cytosol] (R-HSA-8862456)	0.524	20
UniProt:O15169-2 AXIN1			0.524	3
UniProt:P09619 PDGFRB	3	p-12Y-PDGFRB [plasma membrane] (R-HSA-186803) PDGFRB [plasma membrane] (R-HSA-186767) p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039)	0.524	3
UniProt:O75084 FZD7	1	FZD7 [plasma membrane] (R-HSA-517394)	0.504	4
UniProt:P58335 ANTXR2			0.463	2

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