Reactome | ARSA(19-444) [extracellular region]

ARSA(19-444) [extracellular region]

Stable Identifier

R-HSA-6806192

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

ARSA-B, Arylsulfatase A component B, ARSA_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P15289 ARSA

Gene Names

ARSA

Chain

signal peptide:1-18, chain:19-507, chain:19-444, chain:448-507

Reference Genes

BioGPS Gene:410 ARSA

COSMIC (genes):ARSA ARSA

CTD Gene:410 ARSA

dbSNP Gene:410 ARSA

ENSEMBL:ENSG00000100299 ARSA

HGNC:713 ARSA

KEGG:hsa:410 ARSA

Monarch:410 ARSA

NCBI Gene:410 ARSA

OMIM:607574 ARSA

UCSC:P15289 ARSA

Reference Transcript

Other Identifiers

11726503_a_at

11749080_a_at

11749081_x_at

16936709

204443_PM_at

204443_at

236541_PM_at

236541_at

37963_at

3966144

3966145

3966146

3966147

3966148

3966149

3966150

3966151

3966152

3966153

3966154

3966155

3966156

3966157

3966158

3966159

3966160

3966161

3966162

3966163

3966164

3966165

3966166

3966167

3966168

410

72800_at

8077160

83542_at

A_23_P255436

A_33_P3229725

GE58223

GO:0001669

GO:0003824

GO:0004065

GO:0004098

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005764

GO:0005768

GO:0005773

GO:0005783

GO:0005788

GO:0005886

GO:0006629

GO:0006914

GO:0007339

GO:0007584

GO:0008484

GO:0009268

GO:0016020

GO:0016787

GO:0031232

GO:0031410

GO:0035578

GO:0043202

GO:0043226

GO:0043627

GO:0045471

GO:0046872

GO:0051597

GO:0070062

HMNXSV003049402

Hs.157802.0.A1_3p_at

ILMN_1656477

ILMN_2047240

PH_hs_0004942

TC22000918.hg

X52151_at

g7262293_3p_at

Participates

as a member of

Azurophil granule lumen proteins [extracellular region] (Homo sapiens)

Other forms of this molecule

ARSA(448-507) [azurophil granule lumen]

ARSA(19-444) [azurophil granule lumen]

ARSA(448-507) [extracellular region]

ARSA(19-444) [endoplasmic reticulum lumen]

ARSA(448-507) [endoplasmic reticulum lumen]

OxA-ARSA(19-444) [endoplasmic reticulum lumen]

OxA-ARSA(19-444) [lysosomal lumen]

ARSA(448-507) [lysosomal lumen]

Inferred To

Arsa [extracellular region] (Rattus norvegicus)

ARSA(19-444) [extracellular region] (Bos taurus)

ARSA(19-444) [extracellular region] (Gallus gallus)

ARSA(19-444) [extracellular region] (Mus musculus)

ARSA(19-444) [extracellular region] (Schizosaccharomyces pombe)

arsa.1 [extracellular region] (Xenopus tropicalis)

ARSA [extracellular region] (Canis familiaris)

ARSA [extracellular region] (Sus scrofa)

Cross References

OpenTargets

ENSG00000100299

ENSEMBL

ENSP00000412542, ENST00000453344

HPA

ENSG00000100299-ARSA

PRO

P15289

Pharos - Targets

P15289

Orphanet

ARSA

GlyGen

P15289

PDB

1E2S, 2HI8, 1N2K, 1N2L, 1AUK, 1E1Z, 1E3C, 2AIK, 1E33, 2AIJ

HMDB Protein

HMDBP00320

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95231 VENTX	1	VENTX [nucleoplasm] (R-HSA-8853887)	0.556	3
UniProt:Q16512 PKN1	3	p-T774-PKN1 [cytosol] (R-HSA-5623651) PKN1 [cytosol] (R-HSA-5623613) p-T774-PKN1 [nucleoplasm] (R-HSA-5625721)	0.556	3
UniProt:Q8NBK3 SUMF1	1	SUMF1 [endoplasmic reticulum lumen] (R-HSA-1614316)	0.527	3
UniProt:Q03405 PLAUR	7	PLAUR [endoplasmic reticulum membrane] (R-HSA-162703) GPI-PLAUR [endoplasmic reticulum membrane] (R-HSA-162687) PLAUR(306-335) [endoplasmic reticulum lumen] (R-HSA-162707) PLAUR(23-335) [endoplasmic reticulum membrane] (R-HSA-162866) GPI-PLAUR [plasma membrane] (R-HSA-158946) PLAUR [plasma membrane] (R-HSA-6806165) GPI-PLAUR [specific granule membrane] (R-HSA-6806143)	0.527	2
UniProt:Q9Y337 KLK5	4	KLK5 [extracellular region] (R-HSA-8849629) proKLK5 [extracellular region] (R-HSA-8849836) KLK5 propeptide [extracellular region] (R-HSA-8849839) KLK5 [cytosol] (R-HSA-8934778)	0.527	2

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