Reactome | OxA-ARSA(19-444) [endoplasmic reticulum lumen]

OxA-ARSA(19-444) [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-1614359

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

active ARSA-B, Arylsulfatase A component B, ARSA_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P15289 ARSA

Gene Names

ARSA

Chain

signal peptide:1-18, chain:19-507, chain:19-444, chain:448-507

Reference Genes

BioGPS Gene:410 ARSA

COSMIC (genes):ARSA ARSA

CTD Gene:410 ARSA

dbSNP Gene:410 ARSA

ENSEMBL:ENSG00000100299 ARSA

ENSEMBL:ENSG00000100299.18 ARSA

HGNC:713 ARSA

KEGG Gene (Homo sapiens):410 ARSA

Monarch:410 ARSA

NCBI Gene:410 ARSA

OMIM:607574 ARSA

UCSC:P15289 ARSA

Reference Transcript

Other Identifiers

11726503_a_at

11749080_a_at

11749081_x_at

16936709

204443_PM_at

204443_at

37963_at

3966150

3966151

3966152

3966154

3966155

3966156

3966157

3966160

3966161

3966163

3966167

3966168

410

72800_at

8077160

A_33_P3229725

GO:0003824

GO:0004065

GO:0004098

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005764

GO:0005773

GO:0005783

GO:0005788

GO:0006629

GO:0008484

GO:0016787

GO:0031410

GO:0035578

GO:0043202

GO:0043226

GO:0046872

GO:0070062

GO:0110165

HMNXSV003049402

ILMN_2047240

PH_hs_0004942

X52151_at

g7262293_3p_at

Participates

as a component of

active ARSA:Ca2+ [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

ARSA(19-444) [extracellular region]

ARSA(448-507) [extracellular region]

ARSA(19-444) [azurophil granule lumen]

ARSA(448-507) [azurophil granule lumen]

ARSA(448-507) [lysosomal lumen]

OxA-ARSA(19-444) [lysosomal lumen]

ARSA(19-444) [endoplasmic reticulum lumen]

ARSA(448-507) [endoplasmic reticulum lumen]

Inferred To

ARSA [endoplasmic reticulum lumen] (Sus scrofa)

arsa.1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

OxA-ARSA(19-444) [endoplasmic reticulum lumen] (Bos taurus)

OxA-ARSA(19-444) [endoplasmic reticulum lumen] (Canis familiaris)

OxA-ARSA(19-444) [endoplasmic reticulum lumen] (Danio rerio)

OxA-ARSA(19-444) [endoplasmic reticulum lumen] (Gallus gallus)

OxA-ARSA(19-444) [endoplasmic reticulum lumen] (Mus musculus)

Arsa [endoplasmic reticulum lumen] (Rattus norvegicus)

Modified Residues

Name

L-3-oxoalanine (Ser) at 69

Coordinate

PsiMod Name

L-3-oxoalanine (Ser)

PsiMod Definition

A protein modification that effectively converts an L-serine residue to L-oxoalanine.

Cross References

RefSeq

NP_001078897.1, XP_011528992.1, NP_001078896.2, NP_000478.3, NP_001078894.2, NP_001078895.2

OpenTargets

ENSG00000100299

GeneCards

P15289

HPA

ENSG00000100299-ARSA

Ensembl

ENSP00000412542, ENST00000453344, ENSG00000100299

PRO

P15289

Pharos - Targets

P15289

Orphanet

15951

HMDB Protein

HMDBP00320

PDB

1N2K, 1E1Z, 2AIK, 1E33, 1AUK, 1E3C, 2HI8, 2AIJ, 1N2L, 1E2S

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16512 PKN1	3	p-T774-PKN1 [nucleoplasm] (R-HSA-5625721) p-T774-PKN1 [cytosol] (R-HSA-5623651) PKN1 [cytosol] (R-HSA-5623613)	0.556	3
UniProt:O95231 VENTX	1	VENTX [nucleoplasm] (R-HSA-8853887)	0.556	3