SPINK6 binds KLK5

Stable Identifier
R-HSA-8850794
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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SPINK6 binds KLK5
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Extracellular SPINK6 (Serine protease inhibitor Kazal-type 6) binds KLK5 (kallekrein-related peptidase 5), inactivating the latter. KLK5 activity contributes to the process of desquamation, and SPINK6 binding may play a role in the regulation of that process (Meyer-Hoffert et al. 2010).

Literature References
PubMed ID Title Journal Year
20667819 Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases

Hansmann, B, Kantyka, T, He, Y, Schröder, JM, Gläser, R, Meyer-Hoffert, U, Wu, Z, Latendorf, T, Bartels, J, Fischer, J

J. Biol. Chem. 2010
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Orthologous Events
SPINK6 binds KLK5 (Bos taurus)
SPINK6 binds KLK5 (Canis familiaris)
SPINK6 binds KLK5 (Mus musculus)
SPINK6 binds KLK5 (Rattus norvegicus)
SPINK6 binds KLK5 (Sus scrofa)
Authored
Jupe, S  (2016-03-10)
Reviewed
Blumenberg, M  (2016-08-12)
Created
D'Eustachio, P  (2015-12-29)
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